Formamide 甲酰胺

CAS 75-12-7 MFCD00007941

化学结构图

75-12-7
SMILES: NC=O

化学属性

Mol. FormulaCH3NO2
Mol. Weight45.04
Density1.134
Refractive indexn20/D 1.447(lit.)
Boiling Point210
Melting Point2-3
Flash Point175°C(lit.)
TSCAYes
Autoignition Point932 °F
Vapor Density1.55 (vs air)
Vapor Pressure0.08 mmHg ( 20 °C)
SolubilityMISCIBLE
Appearance liquid
Stability易吸潮
pH:A

别名和识别编码

Chemical NameFormamide
Synonym AKOS BBS-00004264 AMIDE C1 Amid kyseliny mravenci C1 酰胺 氨基甲醛 C1 酰胺 氨基甲醛 甲酰胺 CARBAMALDEHYDE FORMAMIDE, DEIONIZED FORMIC ACID AMIDE Formamid Formamid deionisiert Formamide Formamide Methanamide Formic acid amide, Amide C1 Formic acid amide; Amide C1 Formimidic acid Formylamide HYDRANAL®-无水甲酰胺 Methanoic acid, amide formamide formimidic acid methanamide methanoicacid,amide {} {} {} {} {} {} {} {} {} {} {} {} {uni_hamburg} 甲酰胺 甲酰胺 溶液 甲酰胺, 99% 甲酰胺, ACS, 99.5+% 甲酰胺, SPECTROPHOTOMETRIC GRADE, 99+%
CAS Number75-12-7
EC Number200-842-0
Beilstein Registry Number505995
MDL NumberMFCD00007941
PubChem Substance ID713
Reaxys-RN505995
Merck Number4237
Chemical Name Translation甲酰胺
Wiswesser Line NotationZVH
LabNetwork Molecule IDLN00194013
InChIInChI=1S/CH3NO/c2-1-3/h1H,(H2,2,3)
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分类

  • {SNA} Acids and Bases, Alphabetical, BioUltra, DNA和RNA纯化, 分子生物学, 分子生物学试剂, 变性剂, 生化试剂, 试剂
  • Analytical Reagents, Analytical/Chromatography, Auxiliary Reagents & Products for KF Titration, KF Reagents for Special Applications, Karl Fischer Titration Reagents (HYDRANAL), Special Reagent for polar substances, Titration
  • {SNA} Auxiliary Reagents
  • {SNA} Acids and Bases, Core Bioreagents, Life Science Reagents for DNA/RNA Electrophoresis, Life Science Reagents for RNAi, Nucleic Acid Hybridization Reagents, Reagents for Hybridization, Research Essentials, Solvents,

产品应用

  • 离子化溶剂。纸色谱展开剂。动物胶的软化剂。纤维工业的柔软剂。制造甲酸酯类和氢氰酸。

相关文献及参考

  • Merck: 14,4237 Beilstein:2,26
  • Merck: 14,4237
  • Short: II/14a
  • Short: II/19b

安全信息

GHS Symbol
WGK Germany1
Hazard Codes T
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H320 Causes eye irritation 刺激眼睛
  • H316 Causes mild skin irritation 会轻微的刺激皮肤
  • H340 May cause genetic defects 可能导致遗传性缺陷
  • H331 Toxic if inhaled 吸入中毒
  • H318 Causes serious eye damage 严重伤害眼睛
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSLQ0525000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P313
  • P332+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
Storage condition 密封保存 密封保存。测序级2-8°C保存 充氩保存 Hygroscopic 2-8°C
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   26,596,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1250 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - other (direct) parasympathomimetic
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 9,163,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle
   Pathologie.  (Berlin, Ger.) V.254-263, 1966-69.  For publisher information,
   see NSAPCC.  Volume(issue)/page/year: 257,296,1967

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >13500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION           : 500 mmol/L
REFERENCE :
   CAANAT Comptes Rendus de l'Association des Anatomistes.  (Nancy, France)
   V.1-56, 1899-1972.  For publisher information, see ANOBAU.
   Volume(issue)/page/year: 56,712,1972

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION           : 500 mmol/L
REFERENCE :
   CAANAT Comptes Rendus de l'Association des Anatomistes.  (Nancy, France)
   V.1-56, 1899-1972.  For publisher information, see ANOBAU.
   Volume(issue)/page/year: 56,712,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7980 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H.,
   Paris, Masson et Cie, 1971  Volume(issue)/page/year: -,95,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 910 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 30,1557,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2 gm/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H.,
   Paris, Masson et Cie, 1971  Vol

其他信息

  • 化学性质:无色无嗅油状液体,含杂质时略有氨气味。有吸湿性。相对分子质量45.04。相对密度1.1334。熔点2.55℃。沸点210.5℃。折射率1.4475。闪点154℃。粘度3.76mPa·s(20℃)。不溶于醚类及含氯溶剂,微溶于苯,能与水、甲醇、乙醇、乙酸、丙酮、二氧六环、乙二醇、苯酚和低级酯混溶。本品可以溶解酪蛋白,但不溶解白蛋白。也能溶解酪素、葡萄糖、玉米蛋白、明胶、动物胶
  • 外观性质:无色油状液体, 有吸湿性。
  • 毒性分级:中毒
  • 储运特性:库房低温, 通风, 干燥
  • TCI Shanghai:甲酰胺 Formamide,>;98.5%(GC)(75-12-7)
  • 常规方法:甲酰胺商品的贮运可
  • 蒸气压:0.08 mm Hg ( 20 °C)
  • 灭火剂:二氧化碳、化学干粉
  • 化学性质:无色无嗅油状液体,含杂质时略有氨气味。有吸湿性。相对分子质量45.04。相对密度1.1334。熔点2.55℃。沸点210.5℃。折射率1.4475。闪点154℃。粘度3.76mPa·s(20℃)。不溶于醚类及含氯溶剂,微溶于苯,能与水、甲醇、乙醇、乙酸、丙酮、二氧六环、乙二醇、苯酚和低级酯混溶。本品可以溶解酪蛋白,但不溶解白蛋白。也能溶解酪素、葡萄糖、玉米蛋白、明胶、动物胶、树脂、淀粉、木素、乙酸纤维、尼龙以及某些无机盐:铜、铅、锌、锡、钴、铁、铝和镍的氯化物,某些硫酸盐,硝酸盐。在室温下甲酰胺的水解速度很慢,提高温度或加入酸、碱,均可使水解加速。在催化剂存在下,加热至35℃以下,可分解出氰化氢。甲酰胺有两个活泼的官能团,即羰基和酰胺基,容易起化学反应,生成许多含氮杂环化合物。甲酰胺能与无机酸反应,生成甲酸及铵盐。在催化剂存在下与有机卤化物或醇类反应,生成甲酸酯。本品还能与β-二酮、β-亚氨酮、脂肪偶姻、芳烃偶姻、杂环偶姻反应。能与钴盐、铜盐及镍盐等结合生成络合物。甲酰胺遇五氧化二磷等强脱水剂时,可生成氰化氢。与五硫化二磷反应,生成硫甲酰胺。甲酰胺能强烈腐蚀铜、黄铜、铅、橡胶,所以贮存及运输时,应注意。
  • 海关编码:29309070
  • 下游产品:蔗糖硬脂酸酯 --> 头孢地嗪 --> 齐多夫定 --> 2,4-二甲氧基苯甲胺 --> 4-氨基-6-甲氧基嘧啶 --> 苯酮唑 --> 4-氯-5,
  • 用途二:用作合成咪唑、嘧啶、1,3,5-三嗪、咖啡碱的原料,丙烯腈共聚物纺丝、塑料制品防静电涂饰的溶剂等
  • 方法一:1.一步法第二步由一氧化碳与甲醇在甲醇钠作用下生成甲酸甲酯。第二步甲酸甲酯再氨解生成甲酰胺,反应条件为80-100℃和0.2-0.6MPa。此法问题较少。2.甲酸法甲酸与甲醇先进行酯化反应生成甲酸甲酯,然后经氨解生成甲酰胺,再进行精馏分离出甲醇和杂质后即得成品。此法由于成本高已趋向淘汰。3.一步法由一氧化碳与氨在甲醇钠催化作用下,经高压(10-30MPa)和80-100℃温度直接合成甲酰胺4.甲酸和尿素法。5.新方法由甲酸钠和铵盐在一定的温度和压力下反应生成甲酰胺。此法为国内专利发明。
  • Sigma Aldrich:75-12-7(sigmaaldrich)
  • 用途四:离子化溶剂。纸色谱展开剂。动物胶的软化剂。纤维工业的柔软剂。制造甲酸酯类和氢氰酸。
  • 用途三:甲酰胺具有活泼的反应性和特殊的溶解能力,可用作有机合成原料,纸张处理剂,纤维工业的柔软剂,动物胶的软化剂,还用作测定大米中氨基酸含量的分析试剂。在有机合成中,医药方面的用途居多,在农药、染料,颜料,香料,助剂方面也有很多用途。也是优良的有机溶剂,主要用于丙烯腈共聚物的纺丝和离子交换树脂中,以及塑料制品的防静电涂饰或导电涂饰等。此外,还用于分离氯硅烷、提纯油脂等。甲酰胺可发生多种反应,除了由三个氢参与反应外,还可以进行脱水,脱CO,引入氨基,引入酰基和环合等反应。举环合为例。丙二酸二乙酯与甲酰胺环合得到维
  • Alfa Aesar:甲酰胺,SpectrophotometricGrade,99+% Formamide, Spectrophotometric Grade, 99+%(75-12-7)
  • 用途三:甲酰胺具有活泼的反应性和特殊的溶解能力

系列性分类


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