CAS 67-68-5 MFCD00002089-Dimethyl sulfoxide 超干二甲基亚砜 TAO{mole}

Dimethyl sulfoxide 超干二甲基亚砜

CAS 67-68-5 MFCD00002089

化学结构图

SMILES: CS(C)=O

化学属性

Mol. Formula	C2H6OS
Mol. Weight	78.13
Refractive index	1.4770 to 1.4800
Boiling Point	189 °C at 760 mmHg
Density	1.1
Melting Point	18.4 °C
Flash Point	88.89°C
TSCA	Yes
Autoignition Point	573 °F
Vapor Density	2.7 (vs air)
Vapor Pressure	0.42 mmHg ( 20 °C)
Appearance	liquid (temperature dependent)
Solubility	溶于水，溶于乙醇、丙酮、乙醚、氯仿等。
Stability	易吸潮
pH	-:A
Danger-Level	-
Redox	-

别名和识别编码

Chemical Name	Dimethyl sulfoxide
Synonym	Dimethyl sulfoxide {LY} Dimethyl sulfoxide {} {LY} Dimethyl sulfoxide {} {} {LY} Dimethyl sulfoxide {} {} {} {LY} Dimethyl sulfoxide {} {} {} {} {LY} Dimethyl sulfoxide {} {} {} {} {} {LY} Dimethyl sulfoxide {} {} {} {} {} {} {LY} Dimethyl sulfoxide {} {} {} {} {} {} {} {LY} Dimethyl sulfoxide {} {} {} {} {} {} {} {} {LY} Dimethyl sulfoxide {} {} {} {} {} {} {} {} {} {LY} Dimethyl sulfoxide {} {} {} {} {} {} {} {} {} {} {LY} Dimethyl sulfoxide {} {} {} {} {} {} {} {} {} {} {} {LY} Dimethyl sulfoxide {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dimethyl sulfoxide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dimethyl sulfoxide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dimethyl sulfoxide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dimethyl sulfoxide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dimethyl sulfoxide {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number	67-68-5
PubChem Substance ID	354335210
EC Number	200-664-3
Beilstein Registry Number	506008
MDL Number	MFCD00002089
Reaxys-RN	506008
Merck Number	3259
Chemical Name Translation	超干二甲基亚砜
Wiswesser Line Notation	OS1&1
LabNetwork Molecule ID	LN00163813
Canonical SMILES	O=S(C)C

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产品应用

可作有机溶剂、反应介质及有机合成中间体。用途极广。本品具有很高的选择性抽提能力，用作丙烯酸树脂及聚砜树酯的聚合和缩合溶剂、聚丙烯腈及乙酸纤维的聚合抽丝溶剂、烷烃与芳烃分离的抽提溶剂、用于芳烃、丁二烯抽提，腈纶纺丝、塑料溶剂及有机合成染料、制药等工业的反应介质。在医药方面，二甲基亚砜有消炎止痛作用，对皮肤有强渗透力，因而可溶解某些药物，使这类药物向人体渗透从而达到治疗目的。利用二甲基亚砜的这种载体特性，也可作为农药的添加剂。在某些农药中添加少量二甲基亚砜，有助于农药向植物内渗透，以提高药效。二甲基亚砜还可作为合成纤维的染色溶剂、去染剂、染色载体，也可作为回收乙炔、二氧化硫的吸收剂，合成纤维改性剂，防冻剂以及电容介质、刹车油、稀有金属提取剂等。

安全信息

WGK Germany1

Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSPV6210000

Signal word Warning {} {} {} {TCI}

GHS Symbol

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P332+P313
P501 Dispose of contents/container to..… 处理内容物/容器.....
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P305+P351+P338+P337+P313
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。

Hazard statements

H316 Causes mild skin irritation 会轻微的刺激皮肤

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

Hazard Codes Xi

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 220 gm/kg/82W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 28(5),39,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 66 gm/kg/66W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Skin and Appendages - tumors
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 28(5),39,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 65340 mg/kg/66W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - leukemia
   Skin and Appendages - tumors
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 28(5),39,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 59 gm/kg/81W-I
TOXI

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >5500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 15,688,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5360 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   7,104,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7920 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHTPBA Chimica Therapeutica.  (Paris, France)  V.1-8, 1965-73.  For
   publisher information, see EJMCA5.  Volume(issue)/page/year: 3,10,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3100 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - hemorrhage
   Sense Organs and Special Senses (Eye) - conjunctive irritation
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   15,74,1969

{hazard_com

TYPE OF TEST            : LD50 - Lethal do

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 70 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 6200 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 263,107,1991

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 8 pph
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 49,1336,1972

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 25 pph
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 303,127,1993

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 pph
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 42,109,1977

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 1400 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 45,309,1977

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 5500 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   JEEMAF Journal of Embryology and Experimental Morphology.  (Essex, UK)
   V.1-98, 1953-86. For Publisher information, see DEVPED
   Volume(issue)/page/year: 16,49,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOS

TYPE OF TEST            : TDLo - Lowest pu

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 56 gm/kg
SEX/DURATION            : female 6-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 141,110,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 240 gm/kg
SEX/DURATION            : female 1-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
   (Paris, France)  V.1-261, 1835-1965.  For publisher information, see CRASEV.
    Volume(issue)/page/year: 260,327,1965

Restrict -

其他信息

用途三:可作有机溶剂、反应介质及有机合成中间体。用途极广。本品具有很高的选择性抽提能力，用作丙烯酸
回收方法:二甲基亚砜（简称DMSO）作为溶剂时必须考虑回收，降低生产成本。可以利用DMSO易溶于水、苯、甲苯产生缔合物的特点，一般采用萃取和反萃取的方法与其他杂质分离，然后减压精馏得纯品。如：DMSO与无机盐的混合物，用甲苯从混合物中抽出，再向抽出液中加水反萃取DMSO，得到的DMSO水溶液在(1.33～2.00)×103Pa残压下精馏，　得到含量99%以上的DMSO。在芳烃抽提时，正萃取从重整油中抽出芳烃，再向抽出液中加水反萃取，得到含水DMSO，再减压精馏得到纯DMSO。此外，尚有用磷酸二氢钾盐析的方法，用甲醇、乙醇萃取的回收方法，在特定的条件下可以采用。小批量用户不便于回收时可集中起来委托生产厂回收。 DMSO回收的基本途径是减压精馏,但是要满足两个条件,首先是温度必须在120度以下,否则会有安全问题,并且降低回收率.另外一个问题是体系的PH值,比较合适的值是PH=8,这里有设备的安全问题及DMSO本身的分解条件都适合于以上PH值.我用的塔是碳钢的,7-8块塔板,回流比3-2就可以.一般可以达到98-99%含量,装置是2000L的.效果很好的。半连续减压精馏法回收酮康唑生产中二甲基亚砜的方法，步骤如下：（１）将原料打入精馏塔釜中，当液位达到１／３时，开始加热；（２）当精馏塔顶温达到６０℃时，打开内回流冷却器和真空系统；（３）真空度达到０．１～０．１５×１０↑［４］Ｐａ时，控制精馏塔顶出料：当顶温达到６５℃时，精馏塔顶出料为半成品；当顶温达到８０℃时，并发现顶温迅速上升，塔顶出料为二甲亚砜；（４）直到温度达到１１０℃；放空、停止加热；（５）放出塔釜中残液。
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海关编码:29309070
使用限量:FEMA(mg/kg)焙烤制品、无醇饮料、早餐谷物、冷饮、调味汁、肉制品、乳制品、软糖
Acros Organics:二甲亚砜 Methyl sulfoxide, DNAse, RNAse and Protease fr
蒸气压:0.42 mm Hg ( 20 °C)
F:3
二甲基亚砜价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30072491 二甲亚砜 500ml 150元 2011/08/23 30072418 二甲亚砜 500ml 29
方法一:二甲基亚砜一般采用二甲硫醚氧化法制得，由于所用的氧化剂和氧化方式不同，因而有不同的生产工艺。1.甲醇二硫化碳法甲醇和二硫化碳为原料，以γ-Al2O3作催化剂，先合成二甲基硫醚，再与二氧化氮（或硝酸）氧化得二甲基亚砜。 2.双氧水法以丙酮作缓冲介质，使二甲硫醚与双氧水反应。用该法生产二甲基亚砜成本较高，不适于大规模生产。3.二氧化氮法以甲醇和硫化氢在γ-氧化铝作用下生成二甲基硫醚；硫酸与亚硝酸钠反应生成二氧化
Alfa Aesar:二甲基亚砜,SpectrophotometricGrade,99.9+% Dimethyl sulfoxide, Spectrophotometric Grade, 99.9+%(67-68-5)
TCI Shanghai:二甲亚砜[用于液体石蜡测试] Dimethy
使用限量:FEMA(mg/kg)焙烤制品、无醇饮料、早餐谷物、冷饮、调味汁、肉制品、乳制品、软糖、汤品、甜沙司，均0.1～5.0；调味香料100～1000。
下游产品:6-(1H-吡唑-1-基)烟酰腈 --> 1-(咪唑-1-基)苯酚 --> 2-氨基-5-羟基苯甲酸 --> 5-氟吲哚-2-酮 --> 3,5-二甲氧基苯基乙腈 --> 5-溴-2-羟基-3-硝基吡啶 --> 4'-苯氧基苯乙酮 --> 3-苯氧基苯胺 --> (6-(1H-吡唑-1-基)吡啶-3-基)甲醇 --> 胡椒酸酰氯 --> 1-甲基-4-(3'-硝基苯基)哌嗪 --> 4-苯氧基苯酚 --> 2,3-二氰基丙酸乙酯 --> 二甲基硅油 1000 --> 2-吗啉苯甲酸 --> 1-(3-氰基苄基)哌嗪 --> 3-氨基苯并呋喃-2-甲酸乙酯 --> 4-哌嗪基苯甲腈 --> 2-甲基-5-甲氧基吡啶 --> 1-金刚烷乙胺 --> 4-吗啉基苄胺