CAS 67-66-3 MFCD00000826-Chloroform 氯仿(易制毒) TAO{mole}

Chloroform 氯仿(易制毒)

CAS 67-66-3 MFCD00000826

化学结构图

SMILES: ClC(Cl)Cl

化学属性

Mol. Formula	CHCl3
Mol. Weight	119.38
Refractive index	n20/D 1.445(lit.)
Boiling Point	60.5-61.5 °C(lit.)
Density	1.492 g/mL at 25 °C(lit.)
Melting Point	-63 °C(lit.)
TSCA	Yes
Vapor Density	4.1 (vs air)
Vapor Pressure	160 mmHg ( 20 °C)
Solubility	8 G/L (20 ºC)
Flash Point	60.5-61.5°C
Stability	对光敏感

别名和识别编码

Chemical Name	Chloroform
Synonym	Trichloromethane CHLOROFORM 氯仿, SPECTROPHOTOMETRIC GRADE, 99.5+% 三氯甲烷( 易制毒化学品,禁止定购) Trichlormethan 氯仿 Triclorometano 三氯甲烷 METHYLIDYNE TRICHLORIDE Formyl trichloride HCC20 Methane,trichloro- RCRA waste number U044 氯仿,三氯甲烷,哥罗念头氯仿溶液 freon20 氯仿 99.5% (GC) Freon 20 哥罗仿,氯仿 TRICHLOROMETHANE 氯仿;氯仿溶液 Cloroformio AKOS BBS-00004224 氯仿, 不含乙醇, 99+%, .含大约 50PPM戊烯作稳定剂 Trichloroform SOLVENT MC Methylidyne trichloride 三氯甲烷 formyltrichloride 哥罗仿;氯仿 Methane, trichloro- Methane trichloride 氯仿, HPLC GRADE, 99.5+% MIN, 戊烯作稳定剂 chloroform(trichloromethane) 三氯甲烷 054-01 [6] CHCl3 氯仿, ENVIRONMENTAL GRADE, 99.8+%, 乙醇作稳定剂 chloroforme(french) R 20 CHLOROFORM 5000 氯仿, 99%, 以大约 1%乙醇作稳定剂 R 20 (Refrigerant) 氯仿, ACS, 99.8+% NCI-C02686 Trichloormethaan Methyl trichloride 氯仿, HPLC GRADE, 99.5+% MIN 哥罗仿 Chloroform Chloroforme Methenyl trichloride 氯仿溶液
CAS Number	67-66-3
PubChem Substance ID	24871551
EC Number	200-663-8
Beilstein Registry Number	1731042
MDL Number	MFCD00000826
Merck Number	14,2141
Chemical Name Translation	氯仿(易制毒)
Wiswesser Line Notation	GYGG

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品牌质保精细包装现货库存一流品牌服务

产品应用

脂肪、橡胶、树脂、生物碱、油类、蜡、磷和碘的溶剂，广泛用于提取各种带色化合物，校正温度计，色谱分析用溶剂，清洁洗涤剂，测定血清中无机磷，肝功能试验的防腐剂，测钴、锰、铱、碘、磷的提取剂。有机合成。

安全信息

GHS Symbol

WGK Germany3

Hazard Codes Xn F,Xn F,Xi Xn,F,T

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H331 Toxic if inhaled 吸入中毒
H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
H302 Harmful if swallowed 吞食有害
H351 Suspected of causing cancer 怀疑致癌
H319 Causes serious eye irritation 严重刺激眼睛
H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)

RTECSFS9100000

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P304+P340+P312
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P370+P378
P403+P235
P305+P351+P338
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P201 Obtain special instructions before use. 使用前获取专门指示。
P403+P233
P308+P313
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。

Signal word Danger

UN Number UN 1888 6.1/PG 3

Risk Statements

R11 Highly flammable 非常易燃
R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R48/20/22
R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
R36 Irritating to eyes 刺激眼睛
R66 Repeated exposure may cause skin dryness or cracking 反复接触可能导致皮肤干燥或皴裂
R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
R20 Harmful by inhalation 吸入有害
R22 Harmful if swallowed 吞咽有害
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
R45 May cause cancer 可能致癌
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R46 May cause inheritable genetic damage 可能引起遗传基因损害
R38 Irritating to skin 刺激皮肤

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S33 Take precautionary measures against static discharges 对静电采取预防措施；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S7 Keep container tightly closed 保存在严格密闭容器中；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S25 Avoid contact with eyes 避免眼睛接触；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Packing GroupⅢ

Hazard Class6.1

Storage condition 储存温度2-8℃ 2-8°C 密封避光阴凉处保存。

Restrict {} {} 易制毒化学品易制毒

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 98 gm/kg/78W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Endocrine - thyroid tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-0,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13832 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - leukemia
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   5,760,1985

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 70 gm/kg/78W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Endocrine - thyroid tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-0,1976

{haz

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 58968 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Endocrine - thyroid tumors
   Blood - tumors
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   5,760,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 6 gm/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.  (Leipzig,
   Ger. Dem. Rep.)  V.1-109, 1873-1925.  For publisher information, see NSAPCC.
    Volume(issue)/page/year: 97,86,1923

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 10 mg/m3/1Y
TOXIC EFFECTS :
   Behavioral - anorexia (human)
   Gastrointestinal - nausea or vomiting
   Gastrointestinal - other changes
REFERENCE :
   IRGGAJ Internationales Archiv fuer Gewerbepathologie und Gewerbehygiene.
   (Heidelberg, Fed. Rep. Ger.)  V.19-25, 1962-69.  For publisher information,
   see IAEHDW.  Volume(issue)/page/year: 24,127,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 704 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 123,224,1958

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 47702 mg/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ENVRAL Environmental

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 1 pph
REFERENCE :
   ANESAV Anesthesiology.  (Lippincott/Harper, Journal Fulfillment Dept., 2350
   Virginia Ave., Hagerstown, MD 21740)  V.1-    1940- Volume(issue)/page/year:
   43,21,1975

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   ENVRAL Environmental Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-    1967-  Volume(issue)/p

{haz

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg/4D (Intermittent)
REFERENCE :
   ENVRAL Environmental Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-    1967-  Volume(issue)/page/year: 32,72,1983

TYPE OF TEST            : Mutation test systems - not otherw

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 300 ppm/6H
REFERENCE :
   IGAYAY Igaku No Ayumi.  Progress in Medicine.  (Ishiyaku Shuppan K.K.,
   1-7-10, Honkomagom, Bunkyo-ku, Tokyo, Japan)  V.1-    1946-
   Volume(issue)/page/year: 122,978,1982

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 19 mmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham,

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1

TYPE OF TEST            : TDL

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 30 ppm/7H
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   28,442,1974

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20100 ug/m3/1H
SEX/DURATION            : female 7-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB277-077

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
   Contaminants, and Agricultural Wastes.  (Marcel Dekker, 270 Madison Ave.,
   New York, NY 10016)  V.B11-    1976-  Volume(issue)/page/year: 18,333,1983

其他信息

有特殊气味。味甜。高折光，不燃，质重，易挥发。纯品对光敏感，遇光照或与空气中的氧作用，逐渐分解而生成剧毒的光气(碳酰氯)和氯化氢。试剂中常含有0.6%-1%的乙醇作稳定剂。能与醇、苯、醚、石油醚、四氯化碳、二硫化碳和油类等混溶；25℃1ml溶于200ml水。低毒，半数致死量（
外观性质:无色透明重质液体，极易挥发，有特殊气味。
下游产品:吡啶-2.6-二羧酸二甲酯 --> 吡咯烷酮盐酸盐 --> 1-乙基-3-甲基咪唑啉双(三氟甲基磺酰基)亚胺 --> 2,4-二氯苯磺酰氯 --> 3-乙氧基苯酚 --> 对联苯磺酰氯 --> 3-羟基-1-甲基-5-三氟甲基-1H-吡唑 --> 4-正丁基甲苯 --> 阿西莫司 --> 聚(3-烷基噻吩)纤维 --> 吡啶醇 --> 5-溴-2-(吗啉-4-基)嘧啶 --> 4-甲氨基吡啶 --> 2,2'-氧化二乙酰氯 --> 4-(甲基亚磺酰)苯酚 --> 2-氨基-5-溴-噻唑氢溴酸盐 --> 异氰酸叔丁酯 --> N-FMOC-L-甘氨酸 --> 2,3-二氢-1,4-苯并二氧-6-基异硫氰酸酯 --> 1-对甲基苯磺酰咪唑 --> 3,5-二甲基苯基异硫氰酸酯 --> N-七氟丁酰基咪唑 --> B-丁内酯 --> 2-乙氧基苯基异硫氰酸酯 --> 3-氯-2-甲基苯基异硫氰酸酯 --> 3-氟-4-羟基苯甲醛 --> 二苄基亚砜 --> (1R,3S)-1,2,2-三甲基-1,3-环戊烷二胺 --> 2-溴-2',4'-二氯苯乙酮 --> 2-氯-4-甲基苯基异硫氰酸酯 --> 4-氯-2-甲基苯基异硫氰酸酯 --> 3-(N,N-二甲基氨基)丙烯酸乙酯 --> 三甲基铵三氧化硫共聚物 --> 4-硫酰氨基苯甲酰氯DMF 络合物 --> 3,5-二甲氧基苯基异硫氰酸酯 --> 2-氯-5-氯甲基噻唑 --> N-乙氧基羰基-N,N′,N′-三甲基胍 --> C-38杀菌剂 --> 柑橘黄 --> 2-重氮-1-萘酚-5-磺酰氯
挥发性有机化合物(VOCs)单
灭火剂
毒性分级:高毒
化学反应:三氯甲烷由于三个氯原子的诱导效应，化学性质活泼。易水解，生成甲酸和氯化氢；在碱催化剂作用下，可发生加成作用，例如氯仿和丙酮在氢氧化钾作用下，于50℃发生加成反应；在碱溶液中，三氯甲烷与伯胺反应，形成胩，胩有特殊气味，用以检查伯胺的存在。图2为三氯甲烷与伯胺的化学反应。三氯甲烷进一步氯化，可生成四氯化碳。在碱溶液中三氯甲烷与酚反应，生成羟基芳香醛。图
检测方法:GC
有机合成的重要原料:三氯甲烷是有机合成的重要原料，是
三氯甲烷价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 10006818 氯仿（易制毒-2）;哥罗仿;氯仿 500ml 26.8元 2011/08/23 10006828 氯仿（易制毒-2）;哥
Acros Organics:三氯甲烷 Chloroform, stabilized with ethanol, AcroSeal?, Extra Dry(67-66-3)
中毒预防:(1) 呼吸系统防护：空气中浓度超标时，应该佩戴直接式防毒面具 (半面罩)。紧急事态抢救或撤离时，佩戴空气呼吸器。 (2) 眼睛防护：戴化学安全防护眼镜。 (3) 身体防护：穿防毒物渗透工作服。 (4) 手防护：戴
用途三:有机合成原料，主要用来生产氟里昂（F-21、F-22、F-23）、染料和药物，在医学上，常用作麻醉剂。可用作抗生素、香料、油脂、树脂、橡胶的溶剂和萃取剂。与四氯化碳混合可制成不冻的防火液体。还用于烟雾剂的发射药、谷物的熏蒸剂和校准温度的标准液。工业产品通常加有少量乙醇，使生成的光气与乙醇作用生成无毒的碳酸二乙酯。使用工业品前可加入少量浓硫酸振摇后水洗，经氯化钙或碳酸钾干燥，即可得不含
中毒救治:(1) 皮肤接触：立即脱去污
储运特性:库房通风低温干燥; 与食品添加剂分开存放
Sigma
挥发性有机化合物(VOCs)单组分标准液
有特殊气味。味甜。高折光，不燃，质重，易挥发。纯品对光敏感，遇光照或与空气中的氧作用，逐渐分