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分类

• {SNA} Analytical Reagents, Analytical/Chromatography, Buffers & Reagents, Chromatography Reagents & Solvents, HPLC, HPLC Buffers, HPLC Buffers - Solution, Solution
• {SNA} Acids & Bases, Amino Acid Analysis, Amino Acid Analysis Reagents, Analytical Reagents, Analytical/Chromatography, Application Specific Reagents, Bases, Biochemicals and Reagents, Chemical Synthesis, Organic Bases, Peptide Analysis and Characterization, Peptides, Reagents for Amino Acid Analysis, Reagents for amino acid derivatisation & detection, Regents for amino acid analysis, Synth
• {SNA} Buffers & Reagents,
• {SNA} Acids & Bases

产品应用

• An amine commonly used in many synthesis pathways.

相关文献及参考

• The apparent base strength of triethylamine has been increased by its use in combination with certain metal salts, examined by Rathke. For the acylation of malonic esters with acyl chlorides, MgCl2 was found to be effective, whereas other metal salts had no effect: J. Org. Chem., 50, 2622 (1985); Synth. Commun., 15, 1039 (1985); Tetrahedron, 48, 9233 (1993). For the Horner-Wadsworth-Emmons olefination reaction, LiBr or LiCl gave the best results under most conditions, although Mg salts showed some effect; other metal salts were ineffective: J. Org. Chem., 50, 2624 (1985).
• Short: II/25D
• Merck: 14,9666 Beilstein:4,99
• Addition of triethylamine enables the reaction of Grignard reagents with esters to be interrupted at the ketone stage. Deuterium-labelling shows that this is caused by enolization of the ketone. Good yields are obtained unless the ester itself is readily enolized: Synthesis, 877 (1980).
• Merck: 14,9666

安全信息

GHS Symbol

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 12 mg/m3/11W-C
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - visual field changes
REFERENCE :
   IAEHDW International Archives of Occupational and Environmental Health.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.35-    1975-  Volume(issue)/page/year: 57,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 570 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 31,238,1968

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 1 mg/m3
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 36(11),9,1971

其他信息

• 危害:蒸气或液体能刺激皮肤和粘膜。吸入蒸气后，能使呼吸器官、血液循环系统、中枢神经系统、肝脏及其他粘膜组织等机体功能失常。生产现场最高容许浓度30mg/m3。 危险特性：易燃，其蒸气与空气混合可形成爆炸性混合物。遇高热、明火能引起燃烧爆炸。与氧化剂能发生强烈反应。其蒸气比空气重，能在较低处扩散到相当远的地方，遇明火会引着回燃。具有腐蚀性。
• 图谱信息:三乙胺(121-44-8)核磁图( 13 CNMR) 三乙胺(121-44-8)红外图谱(IR1) 三乙胺(
• Hazard Note:Highly Flammable/Corrosive
• F:34
• 防护措施:本品有毒。易燃。蒸气或液体能刺激皮肤和粘膜。吸入蒸气后，能使呼吸器官、血液循环系统、中枢神经系统、肝脏及其他粘膜组织等机体功能失常。生产现场最高容许浓度30mg/m3。防护措施参见“二乙胺”。
• 概述:三乙胺(分子式:C6H15N)又称N,N-二乙基乙胺，最简单的均三取代叔胺，具有叔胺的典型性质，包括成盐、氧化，三乙胺的兴斯堡试验（Hisberg reaction）无反应。外观为无色至淡黄色的透明液体，有强烈
• Alfa Aesar:三乙胺,99+% Triethylamine, 99+%(121-44-8)
• 毒性分级:中毒
• 作用:主要用作有机合成中的碱、催化剂、溶剂和原料，也用作高能燃料、橡胶硫化促进剂、四氟乙烯的阻聚剂、表面活性剂、润湿剂、防腐剂及杀菌剂。 三乙胺是在室温下为液体的最简单的均三取代叔胺，因此在有机合成中被广泛用作溶剂和碱使用，一般缩写为 Et3N、NEt3 或 TEA。它是有机合成中最常用的有机碱之一。沸点89摄氏度左右，比较容易通过蒸馏除去。其盐酸盐和氢溴酸盐在乙醚等有机溶剂中的溶解度也不是很高，因此有时可直接通过过滤分离。更简单的三甲胺在通常条件下则为无色气体，必须加压在储气罐中储存或以40％水溶液的形式储存，不如三乙胺容易使用。 三乙胺可用作Swern氧化反应、脱卤化氢反应等消除反应、Heck反应、硅烯醇醚的制取反应、由酰氯制取酯和酰胺的反应中，以及给羟基、羧基和氨基上保护基时的碱性催化剂。它与盐酸反应可以得到三乙胺盐酸盐，与烷基化试剂反应可得相应的季铵盐。
• 用途一:用于制造医药、农药、阻聚剂、高能燃料、橡胶硫化剂等
• 下游产品:4-氰基苯异氰酸酯 --> 1-苯基-5-三氟甲基-1H-吡唑-4-羧酸乙酯 --> 4-氰基吡啶-4-羧酸 --> 卡莫司他 --> 全氟癸烯对氧苯磺酸钠 --> 2-壬烯酸甲酯 --> 水乳型聚氨酯涂饰剂PU-II系列 --> 6-氟-4-羟基-2-(三氟甲基)喹啉 --> 2-氨基
• Triethylamine is a mobile-phase modifier in RP-HPLC separation of acidic, basic, and neutral drugs. Improves resolution of amino acids and amino acid amides by HPLC by suppressing tailing. Triethylamine is commonly employed in organic synthesis in the preparation of esters and amides from acyl chlorides. It is also useful in dehydrohalogenation reactions and Swern oxidations.
• 常规方法:本品为一级易燃液体，与空气接触能形成爆炸性
• 用途三:在有机合成工业中可用作溶剂、催化剂及原料。可用来制取光气法聚碳酸酯的催化剂、四氟乙烯的阻聚剂、橡胶硫化促进剂，脱漆剂中的特殊溶剂、搪瓷抗硬化剂、表面活性剂、防腐剂、杀菌剂、离子交换树脂、染料、香料、药物、高能燃料和液体火箭推进剂等。医药工业中消耗三乙胺的产品有（消耗定额，t/t）：氨苄青霉素钠（0.465），羟氨苄青霉素（0.391），先锋Ⅳ（2.550），头孢唑啉钠（2.442），头孢拉啶（1.093），氧哌嗪青霉素（0.584），酮康唑（8.00），维生素B6（0.502），氟啶酸（10.00），吡喹酮（0.667），