CAS 56-92-8 MFCD00012703-Histamine Dihydrochloride 组胺二盐酸盐 TAO{mole}

Histamine Dihydrochloride 组胺二盐酸盐

CAS 56-92-8 MFCD00012703

化学结构图

SMILES: Cl.Cl.NCCc1cnc[nH]1

化学属性

Mol. Formula	C5H11Cl2N3
Mol. Weight	184.07
Density	1.14
Melting Point	249-252°C
TSCA	Yes
Solubility	可溶
Appearance	类白色结晶或白色结晶性粉末。熔点 249-252℃，可溶于水。 powder

别名和识别编码

Chemical Name	Histamine dihydrochloride, 99%, reference material
CAS Number	56-92-8
Alfabeta Name	IMIDAZOLEETHANAMINEDIHYDROCHLORIDE H14---
MDL Number	MFCD00012703
Synonym	Histamine (dihydrochloride) {LY} Histamine (dihydrochloride) Histamine Dihydrochloride Histamine Hydrochloride Peremin {} {LY} Histamine (dihydrochloride) {} {} {LY} Histamine (dihydrochloride) {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Histamine (dihydrochloride) {} {} {} {} {} {} {} {} {} {} {}
EC Number	200-298-4
Beilstein Registry Number	3624116
Reaxys-RN	3624116
PubChem Substance ID	5818
Merck Number	4719
Chemical Name Translation	组胺二盐酸盐
Wiswesser Line Notation	T5M CNJ D2Z &GH 2
LabNetwork Molecule ID	LN00001627
InChI	InChI=1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
Canonical SMILES	NCCC1=CN=CN1.Cl.Cl

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分类

{SNA} Agonists, Amino Acid, Amino Acid Library, Bioactive Small Molecule Alphabetical Index, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, H, Histaminergics, Membrane Protein Biology Tools, Metabolic Libraries, Mistaminergics - Agonists, Neuroscience, Neurotransmission, Neurotransmitters, 代谢组学, 代谢通路, 代谢通路图中的代谢产物和辅酶分子, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
{SNA} Bioactive Small Molecule Alphabetical Index, Enzyme Substrates, H, Histamine-N-Methyltransferase,

产品应用

多巴胺(dopamine)直接前体的天然异构体，酪氨酸羟化酶的产物

安全信息

Warnings IRRITANT

Signal word Danger

GHS Symbol

WGK Germany2

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R42/43

Precautionary statements

P233 Keep container tightly closed. ?保持容器密闭。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P302+P352
P304+P340
P305+P351+P338
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P332+P317
P333+P317
P337+P317
P342+P316
P362+P364
P403 Store in a well-ventilated place. 储存在通风良好的地方。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard Codes Xn Xn,Xi Xi

Hazard statements

H303 May be harmfully swallowed 吞食可能有害
H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H319 Causes serious eye irritation 严重刺激眼睛
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
H335 May cause respiratory irritation 可能导致呼吸道刺激

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

RTECSMS1575000

Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moist

UN Number 3335

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1550 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   ACPMAP Actualites Pharmacologiques.  (Paris, France)  No.1-33, 1949-81. For
   publisher information, see JNPHAG.  Volume(issue)/page/year: 24,51,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 184 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 97,1117,1977

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >28 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - corneal damage
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JIDIAQ Journal of Infectious Diseases.  (Univ. of Chicago Press, Journals
   Div., POB 37005, Chicago, IL 60637)  V.1-    1904- Volume(issue)/page/year:
   42,473,1928

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2400 mg/kg
SEX/DURATION            : female 1-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 6,179,1963

其他信息

Alfa Aesar:二盐酸组胺,98+% Histamine dihydrochloride, 98+%(56-92-8)
Acros Organics:组胺二盐酸盐 Histamine dihydrochloride, 99%(56-92-8)
MSDS 信息:2-(4-Imidazolyl)ethylamine dihydrochloride(56-92-8).msds
MOL 文件:56-92-8.mol
TCI Shanghai:组胺二盐酸盐 Histamine Dihydrochloride,>;99.0%(T)(56-92-8)
检测方法:T,NMR
F:1-8-9
图谱信息:组胺二盐酸盐(56-92-8)核磁图( 1 HNMR) 组胺二盐酸盐(56-92-8)红外图谱(IR2) 组胺二盐酸盐(56-92-8)核磁图( 13 CNMR) 组胺二盐酸盐(56-92-8)质谱(MS) 组胺二盐酸盐(56-92-8)红外图谱(IR1)
组胺二盐酸盐价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 62013932 二盐酸组胺 5g 138元 2011/04/16 H0146 组胺二盐酸盐 Histamine Dihydrochloride 1G 130元 2011/04/16 H0146 组胺二盐酸盐 Histamine Dihydrochloride 25G 1220元
Hazard Note:Irritant
color:white to off-white
用途一:生化试剂，用作测定组胺酶的底物。作为医药中间体用于药物制造等用途。
Sigma Aldrich:56-92-8(sigmaaldrich)