CAS 128-09-6 MFCD00005511-N-Chlorosuccinimide N-氯代丁二酰亚胺 TAO{mole}

N-Chlorosuccinimide N-氯代丁二酰亚胺

CAS 128-09-6 MFCD00005511

化学结构图

SMILES: O=C1CCC(=O)N1Cl

化学属性

Mol. Formula	C4H4ClNO2
Mol. Weight	133.53
Density	1.5
Melting Point	148-150°C
TSCA	Yes
Stability	对热、光和湿度敏感
Solubility	溶于水和醇类。
Redox	Oxidation
Boiling Point	216.5 °C at 760 mmHg

别名和识别编码

Chemical Name	N-Chlorosuccinimide
Synonym	N-Chlorosuccinimide {LY} N-Chlorosuccinimide {} {LY} N-Chlorosuccinimide {} {} {LY} N-Chlorosuccinimide {} {} {} {LY} N-Chlorosuccinimide {} {} {} {} {LY} N-Chlorosuccinimide {} {} {} {} {} {LY} N-Chlorosuccinimide {} {} {} {} {} {} {LY} N-Chlorosuccinimide {} {} {} {} {} {} {} {LY} N-Chlorosuccinimide {} {} {} {} {} {} {} {} {LY} N-Chlorosuccinimide {} {} {} {} {} {} {} {} {} {LY} N-Chlorosuccinimide {} {} {} {} {} {} {} {} {} {} {LY} N-Chlorosuccinimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Chlorosuccinimide {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Chlorosuccinimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Chlorosuccinimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Chlorosuccinimide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Chlorosuccinimide
MDL Number	MFCD00005511
CAS Number	128-09-6
EC Number	204-878-8
Beilstein Registry Number	21,380
PubChem Substance ID	31398
Merck Number	2164
Reaxys-RN	113915
Chemical Name Translation	N-氯代丁二酰亚胺
Wiswesser Line Notation	T5VNVTJ BG
LabNetwork Molecule ID	LN00196334
InChI	InChI=1S/C4H4ClNO2/c5-6-3(7)1-2-4(6)8/h1-2H2
Canonical SMILES	O=C(CC1)N(Cl)C1=O

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

有机合成中作氯化剂，抗菌素药物的中间体。

安全信息

Signal word Danger

GHS Symbol

WGK Germany3

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；

Risk Statements

R34 Causes burns 会导致灼伤
R22 Harmful if swallowed 吞咽有害
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P303+P361+P353+P310+P363
P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P330+P331
P405 Store locked up. 上锁保管。
P234 Keep only in original container. 只保留在原来的容器中。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P304+P340+P310

Hazard statements

H290 May be corrosive to metals 可能腐蚀金属。
H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H302 Harmful if swallowed 吞食有害

RTECSUY1013500

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Packing GroupII

UN Number UN 3261 8/PG 2 3261

Storage condition 2-8°C {LY} 2-8°C Moisture Sensitive {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

Hazard Codes C C,Xi 8

Hazard Class8

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 840 mg/kg/70W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   53,695,1974

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   PHRPA6 Public Health Reports.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402)  V.1-    1878-  Volume(issue)/page/year:
   59,541,1944

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHRPA6 Public Health Reports.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402)  V.1-    1878-  Volume(issue)/page/year:
   59,541,1944

其他信息

Hazard Note:Irritant
N-氯代丁二酰亚胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30196627 氯代丁二酰亚胺 250g 199.01元 2011/04/16 C0291 N-氯丁二酰亚胺 N-Chlorosuccinimide 500G 1240元 2011/04/16 C0291 N-氯丁二酰亚胺 N-Chlorosuccinimide 25G 160元
外观:浅黄至白色晶体.
Sigma Aldrich:128-09-6(sigmaaldrich)
TCI Shanghai:N-氯代丁二酰亚胺 N-Chlorosuccinimide,>;98.0%(T)(128-09-6)
Acros Organics:N-氯化琥珀酰亚胺 N-Chlorosuccinimide, 97%(128-09-6)
溶解度:14 g/L水 (20°C)、1g/150ml 乙醇和1g/50ml 苯，，稍溶于醚、氯仿和四氯化碳，溶于丙酮。1：50水溶液对石蕊呈酸性。有氯的气味
上游原料:氨 --> 氯 --> 次氯酸钠 --> 氯酸钠 --> 丁二酸 --> 次氯酸 --> 丁二酰亚胺
海关编码:29251995
用途三:主要应用在普通有机合成如制药,芳香剂合成,农化品中,也用于合成炔诺酮生物制药等有机合成中。N-氯代丁二酰亚胺（128-09-6）也可作为一种表面处理剂,改善有机合成纤维的性能,并使之不易褪色。
方法一:由丁二酸经氨化、氯化而得。将丁二酸加入的反应锅，滴加氨水，搅拌加热，在102℃蒸去水分。真空蒸馏，收集180℃以后馏分，得丁二酰亚胺。将熔化的丁二酰亚胺加至乙酸水溶液中，搅拌冷却至0-5℃，滴加次氯酸钠，控制在8℃以下反应（否则有爆炸危险）。反应液澄清时即达终点，离心，滤饼用水洗至中性，甩干，干燥，得成品。
存储注意事项:光敏感;湿度敏感
检测方法:T,NMR
企业检测指标参考:有效氯≥26 熔点148-153(℃) 干燥失重≤1 硫分最高0.2% 自由酸最高0.02%
用途二:有机合成中作氯化剂，抗菌素药物的中间体。
MOL 文件:128-09-6.mol
F:21
Alfa Aesar:N-氯丁二酰胺,99% N-Chlorosuccinimide, 98%(128-09-6)
用途一:用作医药中间体、有机合成氯化剂，也可用于制备橡胶助剂
MSDS 信息:Chlorosuccinimide(128-09-6).msds
下游产品:2-氯喹啉 --> 3-氨基-4-羟基吡啶盐酸盐 --> (+/-)-5-苯甲酰基-2,3-二氢-1H-吡咯并吡咯烷-1-甲酸 --> 头孢克洛(一水物) --> 2-氯-4-氨基苯胺 --> 4'-溴-3'-氟乙酰苯胺 --> 2-氯-4-(三氟甲基)苯磺酰氯 --> 5-氨基-2,3-二氯吡啶 --> 5-甲基呋喃-2-硼酸 --> 3-(2,6-二氯苯基)-5-甲基异恶唑-4-甲醛 --> 5-甲基-3-苯基异恶唑-4-羧酸 --> 2-氨基-5-氯苯腈 --> 2-乙基环己酮 --> 5-硝基-2,3-二氯吡啶 --> 氟胺氰菊酯 --> 2-正丁基-4(5)-氯-5(4)-甲酰基咪唑 --> 2-氨基-4-苯基-5-噻唑甲酸乙酯 --> 5-硝基-2-羟基-3-氯吡啶
敏感性:Moisture Sensitive