• 原料直供
• 试剂商城
• 直接询价

分类

• {Chemicalbook} 农药中间体: 杀菌剂中间体: 脂肪族类杀菌剂
• {SNA} Amber Glass Bottles, Anhydrous Solvents, Reagent, Solvent Bottles, Solvent Packaging Options, Solvent by Application, Solvents
• {SNA} ACS Grade, ACS Grade Solvents, ACS and Reagent Grade Solvents, Amber Glass Bottles, Carbon Steel Cans with NP
• {SNA} ACS Grade, ACS Grade Solvents, ACS and Reagent Grade Solvents, Amber Glass Bottles, Carbon Steel Cans with NPT Threads, Semi-Bulk Solvents, Solvent Bottles, Solvent Packaging Options, Solvent by Application,
• {SNA} Alpha Sort, Analytical Standards, Analytical/Chromatography, Chromatography,

产品应用

• 硝基甲烷有较大的极性，能与许多有机化合物互溶，是一种良好的溶剂，可用作硝酸纤维素、醋酸纤维素、乙烯基树脂、聚丙烯酸酯涂料和蜂蜡等的溶剂。也可用于制取炸药、火箭、燃料、医药、染料、杀虫剂、杀菌剂、稳定剂、表面活性

相关文献及参考

• Short: II/14a
• For a review of the use of nitro compounds as alkyl anion synthons, including methods for removing the nitro group from the resulting carbon skeletons, see: Synthesis, 833 (1988).
• Short: II/25B
• For a brief feature on uses of this reagent in Organic synthesis, see: Synlett, 1174 (2007).
• For reaction with TosMIC adducts to give pyrroles, see p-Toluenesulfonyl­methyl­ isocyanide, A14312.
• For conditions for the Henry (nitro-aldol) condensation of nitroalkanes with carbonyl compounds, see 1-Nitropropane, A11975. In the Tiffeneau-Demjanov ring expansion of ketones, the nitro aldol is reduced to the ß-hydroxyamine before diazotization; see, e.g. (cyclohexanone to cycloheptanone): Org. Synth. Coll., 4, 221 (1963); review: Org. React., 11, 157 (1960).

安全信息

GHS Symbol

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 188 ppm/6H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-461,1997

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 ppm/6H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Eye) - tumors
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-461,1997

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), zonal
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 11,102,1955

{haz

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BSPLA9 Bulletin de la Societe de Pharmacie de Lille.  (Societe de Pharmacie
   du Lille, 3, rue du Professeur Laguesse, 59045 Lille, Franch)  V.1- 1945- 
   Volume(issue)/page/year: (1),29,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 110 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KHFZAN Khimiko-Farmatsevticheskii Zhurnal.  Chemical Pharmaceutical Journal.
    For English translation, see PCJOAU.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR)  V.1-    1967-  Volume(issue)/page/year: 10(6),53,1976

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 1000 ppm
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   INMEAF Industrial Medicine.  (Chicago, IL)  V.1-18, 1932-49.  For publisher
   information, see IOHSA5.  Volume(issue)/page/year: 16,441,1947

TYPE

其他信息

• 上游原料:硝酸 --> 碳酸钠 --> 亚硝酸钠 --> 硫酸二甲酯 --> 氢氟酸 --> 硼酸 --> 氯乙酸钠 --> 硝基乙烷 --> 菜籽油
• 防护措施:本品有很高的毒性，即使在0.05%以下的浓度也能刺激所有动物的眼睛、呼吸道粘膜，如果长时间吸入会引起深度麻醉。在3%的浓度下吸入两小时可因肺水肿、肝肿、肾脏的刺激而致死。豚鼠LC0.001。操作人员必须佩戴防护用具，防止皮肤和液体产品接触。要求设备密闭，无跑、冒、滴、漏现象，加强局部或整体通风，注意安全。生产操作场所空气中最高容许浓度0.0001。
• 用途五:硝基甲烷有较大的极性，能与许多有机化合物互溶，是一种良好的溶剂，可用作硝酸纤维素、醋酸纤维素、乙烯基树脂、聚丙烯酸酯涂料和蜂蜡等的溶剂。也可用于制取炸药、火箭、燃料、医药、染料、杀虫剂、杀菌剂、稳定剂、表面活性
• 方法二:1.甲烷气相硝化法将稀硝酸喷成雾状使之气化，与经过预热的甲烷（天然气）混合，使硝酸、甲烷、水蒸气保持一定比例。混合气进入以熔盐为加热介质的管道反应器中，在常压和450-550℃条件下直接硝化。反应生成物经冷凝和水吸收，得到的硝基甲烷水溶液经蒸馏得粗硝基甲烷，再经洗涤、精馏即得成品。每吨产品消耗工业级硝酸5500kg，天然气（CH4＞95%）20000m3（标准状况下）。2.硫酸二甲酯与亚硝酸钠反应法将亚硝酸钠和硫酸二甲酯加入反应器中进行反应，反应产物经冷凝、蒸馏
• 储运特性:库房通风低温干燥; 与氧化剂、碱类分开存放
• 硝基甲烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80092528 硝基甲烷（易制爆） 500ml 53.7元 2011/04/16 N0239 硝基甲烷(55%的甲醇溶液,约8.7mol/L) Nitromethane (55% in Methanol, ca. 8.7mol/L) 25ML 134元 2011/04/16 N0239 硝基甲烷(55%的甲醇溶液,约8.7mol/L) Nitromethane (55% in Methanol, ca. 8.7mol/L) 500ML 333元
• F:3-10
• 方法一:其制备方法是将甲烷经预热，与气化的稀硝酸、水蒸气按一定摩尔比混合，混合气进入以熔盐为加热介质的管式反应器，反应温度约在450℃左右，反应生成物(气态)经冷液和水吸收，硝基甲烷的水溶液(冷液和水吸收液)经蒸馏得粗硝基甲烷，再经化学洗涤和精馏得纯品硝基甲烷。 CH 4 +HNO 3 →CH 3 NO 2 +H 2 O
• 下游产品:4,5,6,7-四氢噻吩[3,2-c]吡啶盐酸盐 --> 2,6-二甲基苯甲醛 --> 3-(2- 甲氧基 -5- 甲基苯基 )-3- 苯基丙酸 --> 百草枯 --> 噻氯匹定 --> 7-甲基异喹啉 --> 2-硝基丙烷 --> 6-氟色胺盐酸盐 --> 邻氟苯乙胺 --> 2-溴-2-硝基-1,3-丙醇 --> 马洛替酯 --> 噻奈普汀 --> DL-异丝氨酸 --> 1-硝基丙烷 --> 黄莲素 --> 2-甲氧基-4-(2-硝基乙烯)酚 --> 2-(3,4-二羟基苯基)乙胺 --> 7-羟基-6-甲氧基-3,4-二氢异喹啉 --> 氰基亚甲基三正丁基膦 --> 3-甲氧基-4-嘧啶羧基 酸 --> 三羟甲基氨基甲烷 --> 3-硝基苯并呋喃-5-醇 --> 4-甲氧基多巴胺盐酸盐 --> 聚丁噻吩 --> N-甲基-1-甲硫基-2-硝基乙烯胺 --> 反式-2-(2-硝基乙烯基)噻吩 --> 4-(三氟甲氧基)苯乙酮 --> 非诺多泮 --> 环庚酮 --> 4-(2-氨基乙基)-2-甲氧基苯酚 --> 1-硝甲基环己醇 --> 三(羟甲基)硝基甲烷 --> 氨甲环己醇盐酸盐 --> 反式硝基苯乙烯
• Sigma Aldrich:75-52-5(sigmaaldrich)
• 毒性分级:中毒
• 用途三:硝基甲烷是杀菌剂溴硝醇的中间体。
• TCI
• 类别:易燃液体
• Acros Organics:硝基甲烷 Nitromethane, for analysis, 99+%(75-52-5)
• 方法二:1.甲烷气相硝化