CAS 123-39-7 MFCD00003280-N-Methylformamide N-甲基甲酰胺 TAO{mole}

N-Methylformamide N-甲基甲酰胺

CAS 123-39-7 MFCD00003280

化学结构图

SMILES: CNC=O

化学属性

Mol. Formula	C2H5NO
Mol. Weight	59.07
Density	1.011
Refractive index	1.4310 to 1.4340
Boiling Point	199°C at 760 mmHg
Melting Point	-3.2°C
Flash Point	81.5±3.7 °C
TSCA	Yes
Solubility	MISCIBLE
pH	:A

别名和识别编码

Chemical Name	N-Methylformamide
Synonym	N-Methylformamide {LY} N-Methylformamide {} {LY} N-Methylformamide {} {} {LY} N-Methylformamide {} {} {} {LY} N-Methylformamide {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} { {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number	123-39-7
EC Number	204-624-6
Beilstein Registry Number	4,58
MDL Number	MFCD00003280
PubChem Substance ID	31254
Merck Number	6076
Reaxys-RN	1098352
Chemical Name Translation	N-甲基甲酰胺
Wiswesser Line Notation	VHM1
LabNetwork Molecule ID	LN00224732
InChI	InChI=1S/C2H5NO/c1-3-2-4/h2H,1H3,(H,3,4)
Canonical SMILES	O=CNC

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产品应用

是重要的有机化工原料和中间体，是一种性能较好的有机溶剂。用于合成高效低毒的单甲咪，双甲咪等。用作有机合成的反应溶剂和精制溶剂。还广泛用于医药、染料、香料及电解、电镀工业等。

安全信息

Signal word

GHS Symbol

WGK Germany1

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P308+P313
P201 Obtain special instructions before use. 使用前获取专门指示。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P405 Store locked up. 上锁保管。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338+P337+P313
P308+P311
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P302+P352+P312+P362+P364

Hazard statements

H303 May be harmfully swallowed 吞食可能有害
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
H312 Harmful in contact with skin 皮肤接触有害

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSLQ3000000

Hazard Codes T

Packing GroupII

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - corneal damage
   Behavioral - somnolence (general depressed activity)
   Musculoskeletal - other changes
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 57(2),30,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volu

{hazar

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 802 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1580 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 34,173,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 70 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   DABBBA Dissertation Abstracts International, B: The Sciences and
   Engineering.  (University Microfilms International, 300 N. Zeeb Rd., Ann
   Arbor, MI 48106)  V.30-    1969-  Volume(issue)/page/year: 40,549,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 650 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 30,1557,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 650 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted

Storage condition -20°C, stored under nitrogen {LY} -20°C, stored under nitrogen Store at room temperature {} {LY} -20°C, stored under nitrogen {} {} {LY} -20°C, stored under nitrogen {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored

其他信息

上游原料:甲酸 --> 一甲胺 --> 甲酸乙酯 --> 一氧化碳 --> 甲酸甲酯
{Chem
方法二:1.甲胺法由甲胺与一氧化碳反应制得。2.甲酸甲酯法由甲酸甲酯与甲胺反应而得。3.由甲酸乙酯和甲胺反应而得。将甲酸乙酯加入反应器中，在冷却下加入甲胺水溶液，于40℃回流反应。然后放置3d，减压回收乙醇得到粗品。再经减压蒸馏而得成品。
毒性分级:中毒
灭火剂:泡沫、二氧化碳、雾状水、砂土
用途三:用作有机合成原料，用于农药杀虫药剂、医药、合成革、人造革等的合成；以及用作化纤纺织溶剂等。
急性毒性:口服- 大鼠 LD50: 4000 毫克/ 公斤; 口服- 小鼠 LD50: 2600 毫克/ 公斤
刺激数据:眼睛- 兔子 100 毫克
下游产品:双甲眯 --> 2-甲基氨基吡啶
MOL 文件:123-39-7.mol
Alfa Aesar:N-甲基甲酰胺,99% N-Methylformamide, 99%(123-39-7)
Sigma Aldrich
有氨味。可与苯互溶，溶于水、醇和丙酮，不溶于醚。
用途四:是重要的有机化工原料和中间体，是一种性能较好的有机溶剂。用于合成高效低毒的单甲咪，双甲咪等。用作有机合成的反应溶剂和精制溶剂。还广泛用于医药、染料、香料及电解、电镀工业等。
类别:易燃液体
图谱信息:N-甲基甲酰胺(123-39-7)核磁图( 13 CNMR) N-甲基甲酰胺(123-39-7)红外图谱(IR1) N-甲基甲酰胺(123-39-7)核磁图( 1 HNMR) N-甲基甲酰胺(123-39-7)质谱(MS)
可燃性危险特性:遇明火、高温、强氧化剂可燃;燃烧排放有毒氮氧化物烟雾
方法一:N-甲基甲酰胺主要有以下三种合成工艺。 (1)甲胺法由甲胺与一氧化碳作用而得。CO+CH 3 NH 2 →HCONHCH 3 将一甲胺69.62％(质量分数)、甲醇29.87％(质量分数)和甲醇钠0.5％(质量分数)(对于一甲胺为0.72％)的混合物向反应器供给87.05kg/h，同时供给含量为99.5％的一氧化碳56.5kg/h，反应温度90℃，压力2.53MPa。每小时取出含一甲胺80.5％(质量分数)的混合物140.75kg，即N-甲基甲酰胺生成量为每小时113.4kg，1L反应器的生产能力为每小时1.89kg N-甲基甲酰胺。 (2)甲酸甲酯法由甲酸甲酯与甲胺反应而得。 CH 3 NH 2 +HCOOCH 3 →HCONHCH 3 +CH 3 OH 产物经初馏、精馏而得成品，总收率达90％；产品含量95％～99.5％以上。 (3)甲酸乙酯法由甲酸乙酯和甲胺作用而得。 HCOOC 2 H 5 +CH 3 NH 2 →HCONHCH 3 +C 2 H 5 OH 先将甲酸乙酯加入反应罐中，然后在冷却下加入甲胺水溶液[甲酸乙酯和甲胺水溶液按1∶1.2(mol)配料]，于40℃回流搅拌，然后放置3d，减压回收乙醇，粗品经减压蒸馏而得成品。
储运特性:包装完整、轻装轻放; 库房通风、远离明火、高温、与氧化剂、酸分开
TCI Shanghai:N-甲基甲酰胺 N-Methylformamide,>;99.0%(GC)(123-39-7)
用途二:N-甲基甲酰胺是一种重要的有机合成原料，用于农药杀虫杀螨剂单甲脒、双甲脒的合成，也用于生产医药、合成革、人造革以及用作化纤纺织溶剂等。
Acros Organics:N-甲基甲酰胺 N-Methylformamide, 99+%(123-39-7)
N-甲基甲酰胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 xw010203 N-甲基甲酰胺;N-甲酰基甲胺 100g 85元 2011/04/16 F0059 N-甲基甲酰胺 N-Methylformamide 25G 175元 2011/04/16 F0059 N-甲基甲酰胺 N-Methylformamide 500G 550元