Formamide 甲酰胺
CAS 75-12-7 MFCD00007941
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资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Acids and Bases, Alphabetical, BioUltra, DNA和RNA纯化, 分子生物学, 分子生物学试剂, 变性剂, 生化试剂, 试剂
- Analytical Reagents, Analytical/Chromatography, Auxiliary Reagents & Products for KF Titration, KF Reagents for Special Applications, Karl Fischer Titration Reagents (HYDRANAL), Special Reagent for polar substances, Titration
- {SNA} Auxiliary Reagents
- {SNA} Acids and Bases, Core Bioreagents, Life Science Reagents for DNA/RNA Electrophoresis, Life Science Reagents for RNAi, Nucleic Acid Hybridization Reagents, Reagents for Hybridization, Research Essentials, Solvents,
产品应用
- 离子化溶剂。纸色谱展开剂。动物胶的软化剂。纤维工业的柔软剂。制造甲酸酯类和氢氰酸。
相关文献及参考
- Merck: 14,4237 Beilstein:2,26
- Merck: 14,4237
- Short: II/14a
- Short: II/19b
安全信息
GHS Symbol
- H351 Suspected of causing cancer 怀疑致癌
- H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- H320 Causes eye irritation 刺激眼睛
- H316 Causes mild skin irritation 会轻微的刺激皮肤
- H340 May cause genetic defects 可能导致遗传性缺陷
- H331 Toxic if inhaled 吸入中毒
- H318 Causes serious eye damage 严重伤害眼睛
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- P305+P351+P338+P337+P313
- P308+P313
- P332+P313
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 26,596,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1250 mg/kg TOXIC EFFECTS : Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold REFERENCE : TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 9,163,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle Pathologie. (Berlin, Ger.) V.254-263, 1966-69. For publisher information, see NSAPCC. Volume(issue)/page/year: 257,296,1967
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >13500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PJPPAA Polish Journal of Pharmacology and Pharmacy.
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Non-mammalian species Cells - not otherwise specified DOSE/DURATION : 500 mmol/L REFERENCE : CAANAT Comptes Rendus de l'Association des Anatomistes. (Nancy, France) V.1-56, 1899-1972. For publisher information, see ANOBAU. Volume(issue)/page/year: 56,712,1972
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Non-mammalian species Cells - not otherwise specified DOSE/DURATION : 500 mmol/L REFERENCE : CAANAT Comptes Rendus de l'Association des Anatomistes. (Nancy, France) V.1-56, 1899-1972. For publisher information, see ANOBAU. Volume(issue)/page/year: 56,712,1972
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 7980 mg/kg SEX/DURATION : female 7-12 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : 85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971 Volume(issue)/page/year: -,95,1971
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE : 910 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1557,1980
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 2 gm/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : 85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971 Vol
其他信息
- 化学性质:无色无嗅油状液体,含杂质时略有氨气味。有吸湿性。相对分子质量45.04。相对密度1.1334。熔点2.55℃。沸点210.5℃。折射率1.4475。闪点154℃。粘度3.76mPa·s(20℃)。不溶于醚类及含氯溶剂,微溶于苯,能与水、甲醇、乙醇、乙酸、丙酮、二氧六环、乙二醇、苯酚和低级酯混溶。本品可以溶解酪蛋白,但不溶解白蛋白。也能溶解酪素、葡萄糖、玉米蛋白、明胶、动物胶
- 外观性质:无色油状液体, 有吸湿性。
- 毒性分级:中毒
- 储运特性:库房低温, 通风, 干燥
- TCI Shanghai:甲酰胺 Formamide,>;98.5%(GC)(75-12-7)
- 常规方法:甲酰胺商品的贮运可
- 蒸气压:0.08 mm Hg ( 20 °C)
- 灭火剂:二氧化碳、化学干粉
- 化学性质:无色无嗅油状液体,含杂质时略有氨气味。有吸湿性。相对分子质量45.04。相对密度1.1334。熔点2.55℃。沸点210.5℃。折射率1.4475。闪点154℃。粘度3.76mPa·s(20℃)。不溶于醚类及含氯溶剂,微溶于苯,能与水、甲醇、乙醇、乙酸、丙酮、二氧六环、乙二醇、苯酚和低级酯混溶。本品可以溶解酪蛋白,但不溶解白蛋白。也能溶解酪素、葡萄糖、玉米蛋白、明胶、动物胶、树脂、淀粉、木素、乙酸纤维、尼龙以及某些无机盐:铜、铅、锌、锡、钴、铁、铝和镍的氯化物,某些硫酸盐,硝酸盐。在室温下甲酰胺的水解速度很慢,提高温度或加入酸、碱,均可使水解加速。在催化剂存在下,加热至35℃以下,可分解出氰化氢。甲酰胺有两个活泼的官能团,即羰基和酰胺基,容易起化学反应,生成许多含氮杂环化合物。甲酰胺能与无机酸反应,生成甲酸及铵盐。在催化剂存在下与有机卤化物或醇类反应,生成甲酸酯。本品还能与β-二酮、β-亚氨酮、脂肪偶姻、芳烃偶姻、杂环偶姻反应。能与钴盐、铜盐及镍盐等结合生成络合物。甲酰胺遇五氧化二磷等强脱水剂时,可生成氰化氢。与五硫化二磷反应,生成硫甲酰胺。甲酰胺能强烈腐蚀铜、黄铜、铅、橡胶,所以贮存及运输时,应注意。
- 海关编码:29309070
- 下游产品:蔗糖硬脂酸酯 --> 头孢地嗪 --> 齐多夫定 --> 2,4-二甲氧基苯甲胺 --> 4-氨基-6-甲氧基嘧啶 --> 苯酮唑 --> 4-氯-5,
- 用途二:用作合成咪唑、嘧啶、1,3,5-三嗪、咖啡碱的原料,丙烯腈共聚物纺丝、塑料制品防静电涂饰的溶剂等
- 方法一:1.一步法第二步由一氧化碳与甲醇在甲醇钠作用下生成甲酸甲酯。第二步甲酸甲酯再氨解生成甲酰胺,反应条件为80-100℃和0.2-0.6MPa。此法问题较少。2.甲酸法甲酸与甲醇先进行酯化反应生成甲酸甲酯,然后经氨解生成甲酰胺,再进行精馏分离出甲醇和杂质后即得成品。此法由于成本高已趋向淘汰。3.一步法由一氧化碳与氨在甲醇钠催化作用下,经高压(10-30MPa)和80-100℃温度直接合成甲酰胺4.甲酸和尿素法。5.新方法由甲酸钠和铵盐在一定的温度和压力下反应生成甲酰胺。此法为国内专利发明。
- Sigma Aldrich:75-12-7(sigmaaldrich)
- 用途四:离子化溶剂。纸色谱展开剂。动物胶的软化剂。纤维工业的柔软剂。制造甲酸酯类和氢氰酸。
- 用途三:甲酰胺具有活泼的反应性和特殊的溶解能力,可用作有机合成原料,纸张处理剂,纤维工业的柔软剂,动物胶的软化剂,还用作测定大米中氨基酸含量的分析试剂。在有机合成中,医药方面的用途居多,在农药、染料,颜料,香料,助剂方面也有很多用途。也是优良的有机溶剂,主要用于丙烯腈共聚物的纺丝和离子交换树脂中,以及塑料制品的防静电涂饰或导电涂饰等。此外,还用于分离氯硅烷、提纯油脂等。甲酰胺可发生多种反应,除了由三个氢参与反应外,还可以进行脱水,脱CO,引入氨基,引入酰基和环合等反应。举环合为例。丙二酸二乙酯与甲酰胺环合得到维
- Alfa Aesar:甲酰胺,SpectrophotometricGrade,99+% Formamide, Spectrophotometric Grade, 99+%(75-12-7)
- 用途三:甲酰胺具有活泼的反应性和特殊的溶解能力