Dehydrogenase

下级目录

AZD4017

AZD8329

ASP9521

N6022

IDH-305

瓦他拉尼碱二盐酸盐

AVN-944

Vidofludimus

5-氟-1-(四氢-2-糠基)尿嘧啶

6-THIOGUANINE

DL-Sulforaphane

Trilostane

Mercaptopurine

6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid

4-Thiazolecarboxamide, 2-beta-D-ribofuranosyl-

5-Fluoro-5'-deoxyuridine

5-乙炔基尿嘧啶

A77 1726

Gimeracil

目录项下的产品

1024033-43-9 / MFCD124033439
AZD4017 is a potent, selective, and orally bioavailable11β-HSD1 inhibitor (11β-hydroxysteroid dehydrogenase type 1 inhibitor). Inhibition of 11β-HSD1 is an attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome. AZD4017 is a nicotinic amide derived carboxylic acid class of inhibitors that has good potency, selectivity, and pharmacokinetic characteristics. AZD4017) is an effective inhibitor of 11β-HSD1 in human adipocytes and exhibits good druglike properties and as a consequence was selected for clinical development.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1048668-70-7 / MFCD148668707
AZD8329 is a potent, selective 11β-HSD1 inhibitor (11β-hydroxysteroid dehydrogenase type 1 inhibitor) with reduced acyl glucuronide liability. AZD8329 demonstrates to have improved technical profile in terms of both solubility and pharmacokinetics. The extent of acyl glucuronidation was reduced through structural optimization of both the carboxylic acid and amide substituents, coupled with a reduction in lipophilicity leading to an overall increase in metabolic stability.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1126084-37-4 / MFCD30532740
1-[1-[(5-Methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl]-2-methylpropan-2-ol
1-[1-[(5-甲氧基-1H-吲哚-2-基)羰基]哌啶-4-基]-2-甲基-2-丙醇

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

1208315-24-5 / MFCD308315245
3-(5-(4-(1H-Imidazol-1-Yl)Phenyl)-1-(4-Carbamoyl-2-Methylphenyl)-1H-Pyrrol-2-Yl)Propanoic Acid
3-(5-(4-(1H-咪唑-1-基)苯基)-1-(4-氨基甲酰基-2-甲基苯基)-1H-吡咯-2-基)丙酸

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1628805-46-8 / MFCD728805468
IDH305 is an inhibitor of the citric acid cycle enzyme isocitrate dehydrogenase [NADP] cytoplasmic (isocitrate dehydrogenase 1; IDH1) with mutations at residue R132 (IDH1(R132)), with potential antineoplastic activity. Upon administration, IDH305 specifically inhibits IDH1(R132) mutant forms in the cytoplasm, which inhibits the formation of the oncometabolite 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1(R132)-expressing tumor cells.
(R)-4-((S)-1-氟乙基)-3-(2-(((S-1-(4-甲基-2'-(三氟甲基)-[3,4'-联吡啶]-6-基)乙基)氨基)嘧啶-4-基)恶唑烷-2-酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

212141-51-0 / MFCD12141510
Vatalanib Dihydrochloride
瓦他拉尼二盐酸盐

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

297730-17-7 / MFCD97730177
(R)-1-Cyanobutan-2-Yl ((S)-1-(3-(3-(3-Methoxy-4-(Oxazol-5-Yl)Phenyl)Ureido)Phenyl)Ethyl)Carbamate
(R)-1-氰基丁-2-基((S)-1-(3-(3-(3-甲氧基-4-(恶唑-5-基)苯基)脲基)苯基)乙基)氨基甲酸酯

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

717824-30-1 / MFCD17824301
Vidofludimus, also known as 4SC 101 or SC12267, is a novel orally active and potent DHODH inhibitor. In vitro, 4SC-101 is a potent inhibitor of human DHODH, inhibits lymphocyte proliferation, and uniquely blocks phytohemagglutinin-stimulated IL-17 production by lymphocytes. In vivo, oral administration of 4SC-101 effectively improved both chronic DSS and acute TNBS colitis in mice. 4SC-101 may have potential for the treatment of intestinal inflammation. Dihydroorotate dehydrogenase (DHODH) is a key enzyme involved in pyrimidine biosynthesis. DHODH is a known target for the treatment of autoimmune diseases.
2-((3-氟-3'-甲氧基-[1,1'-联苯]-4-基)氨甲酰)环戊-1-烯羧酸

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

17902-23-7 / MFCD00012351
Tegafur
替加氟

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

154-42-7 / MFCD00127785
2-Amino-1,9-dihydro-6H-purine-6-thione
6-硫鸟嘌呤

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

安徽省
中华人民共和国
上海市
天津市
√

4478-93-7 / MFCD00198068
Sulforaphane
萝卜硫素

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
上海市
√
北京市

13647-35-3 / MFCD00199295
Trilostane
曲洛斯坦

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

50-44-2 / MFCD00233552
6-Mercaptopurine
6-巯基嘌呤，无水

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

武汉市
√
成都市
安徽省
中华人民共和国
上海市
天津市
北京市

96187-53-0 / MFCD00866437
Brequinar
布喹那

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
北京市
√

60084-10-8 / MFCD00866494
2-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)Thiazole-4-Carboxamide
2-((2R,3R,4S,5R)-3,4-二羟基-5-(羟甲基)四氢呋喃-2-基)噻唑-4-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

3094-09-5 / MFCD00866530
Doxifluridine
5'-脱氧-5-氟尿苷

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

安徽省
√
武汉市
中华人民共和国
上海市
天津市
北京市

59989-18-3 / MFCD00871973
5-Ethynylpyrimidine-2,4(1H,3H)-Dione
5-乙炔基嘧啶-2,4(1H,3H)-二酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

108605-62-5 / MFCD00910058
2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide
2-氰基-3-羟基-N-(4-三氟甲基苯基)巴豆酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
北京市
√

103766-25-2 / MFCD08458352
5-Chloropyridine-2,4-Diol
5-氯-2,4-二羟基吡啶

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
上海市
√