3-(5-(4-(1H-Imidazol-1-Yl)Phenyl)-1-(4-Carbamoyl-2-Methylphenyl)-1H-Pyrrol-2-Yl)Propanoic Acid 3-(5-(4-(1H-咪唑-1-基)苯基)-1-(4-氨基甲酰基-2-甲基苯基)-1H-吡咯-2-基)丙酸
CAS 1208315-24-5 MFCD308315245
化学结构图
SMILES: Cc1cc(C(N)=O)ccc1-n1c(CCC(=O)O)ccc1-c1ccc(-n2ccnc2)cc1
化学属性
| Mol. Weight | 414.46 |
|---|---|
| Appearance | white to off-white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 3-(5-(4-(1H-咪唑-1-基)苯基)-1-(4-氨基甲酰基-2-甲基苯基)-1H-吡咯-2-基)丙酸 |
|---|---|
| Chemical Name | 3-(5-(4-(1H-Imidazol-1-Yl)Phenyl)-1-(4-Carbamoyl-2-Methylphenyl)-1H-Pyrrol-2-Yl)Propanoic Acid |
| Formula | C24H22N4O3 |
| Synonym | N6022; N-6022; N 6022. |
| IUPAC Name | 3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid |
| InChIKey | YVPGZQLRPAGKLA-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H22N4O3/c1-16-14-18(24(25)31)4-9-21(16)28-20(8-11-23(29)30)7-10-22(28)17-2-5-19(6-3-17)27-13-12-26-15-27/h2-7,9-10,12-15H,8,11H2,1H3,(H2,25,31)(H,29,30) |
| Canonical SMILES | O=C(O)CCC1=CC=C(C2=CC=C(N3C=CN=C3)C=C2)N1C4=CC=C(C(N)=O)C=C4C |
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产品应用
- N6022 is a potent, selective, reversible, and efficacious S-nitrosoglutathione reductase (GSNOR) inhibitor and is currently undergoing clinical development for the treatment of acute asthma. GSNOR is a member of the alcohol dehydrogenase family (ADH) and regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO).
