5-Chloropyridine-2,4-Diol 5-氯-2,4-二羟基吡啶
CAS 103766-25-2 MFCD08458352
化学结构图
SMILES: O=c1cc(O)[nH]cc1Cl
化学属性
| Mol. Formula | C5H4ClNO2 |
|---|---|
| Mol. Weight | 145.54 |
| Density | 1.422 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 5-Chloropyridine-2,4-Diol |
|---|---|
| CAS Number | 103766-25-2 |
| Synonym | 2(1H)-Pyridinone,5-chloro-4-hydroxy-(9CI) 5-Chloro-2,4-dihydroxypyridine 5-Chloro-2,4-pyridinediol 5-Chloro-4-hydroxy-2-pyridone 5-chloropyridine-2,4-diol CDHP GIMERACIL Gimeracil,(CDHP) Gimeracil; chlorodihydroxypyridine. Abbreviation: CDHP. gimestat （CDHP）Gimeracil |
| MDL Number | MFCD08458352 |
| Reaxys-RN | 119489 |
| Beilstein Registry Number | 119489 |
| PubChem Substance ID | 87560206 |
| EC Number | 250-023-7 |
| Chemical Name Translation | 5-氯-2,4-二羟基吡啶 |
| Formula | C5H4ClNO2 |
| IUPAC Name | 5-chloro-2-hydroxypyridin-4(1H)-one |
| InChIKey | ZPLQIPFOCGIIHV-UHFFFAOYSA-N |
| InChI | InChI=1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9) |
| Canonical SMILES | O=C1C=C(O)NC=C1Cl |
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分类
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Gimeracil is a pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
相关文献及参考
- Shirasaka, T., et al.: Cancer Res., 56, 2602 (1996),
- Patt, Y., et al.: J. Clin. Oncol., 22, 271 (2004),
- Shirao, K., et al.: Cancer, 100, 2355 (2004),
安全信息
GHS Symbol
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
其他信息
- TCI Shanghai:4-羟基-5-氯-2-(1H)吡啶酮 5-Chloro-4-hydroxy-2(1H)-pyridinone,>;98.0%(LC)(T)(103766-25-2)
