5-Ethynylpyrimidine-2,4(1H,3H)-Dione 5-乙炔基嘧啶-2,4(1H,3H)-二酮
CAS 59989-18-3 MFCD00871973
化学结构图
SMILES: C#Cc1c[nH]c(=O)[nH]c1=O
化学属性
| Mol. Formula | C6H4N2O2 |
|---|---|
| Mol. Weight | 136.11 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 5-Ethynylpyrimidine-2,4(1H,3H)-Dione |
|---|---|
| CAS Number | 59989-18-3 |
| Synonym | 5-Ethynyl-2,4(1H,3H)-pyrimidinedione 5-Ethynyluracil 776C85; DH300004; GW776; GW-776; GW 776; GW-776C85; GW 776C85; GW776C85; NSC 687296; 5-ethynyluracil; ethynyluracil. NSC 687296 |
| Chemical Name Translation | 5-乙炔基嘧啶-2,4(1H,3H)-二酮 |
| Reaxys-RN | 638299 |
| MDL Number | MFCD00871973 |
| PubChem Substance ID | 253661150 |
| Merck Number | 3584 |
| Formula | C6H4N2O2 |
| IUPAC Name | 5-ethynylpyrimidine-2,4(1H,3H)-dione. |
| InChIKey | JOZGNYDSEBIJDH-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H4N2O2/c1-2-4-3-7-6(10)8-5(4)9/h1,3H,(H2,7,8,9,10) |
| Canonical SMILES | O=C1NC(C(C#C)=CN1)=O |
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分类
- Nucleotides
- Bases & Related Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Eniluracil, also known as GW776 and GW776C85, is an orally active and irreversible inhibitor of dihydropyrimidine dehydrogenase. Eniluracil inhibits dihydropyrimidine dehydrogenase, the rate-limiting enzyme that catabolizes and inactivates 5-fluorouracil (5-FU) in the liver. Co-administration of ethynyluracil permits the oral administration of 5-FU. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
相关文献及参考
- Morcuende, R., et al.: Clin. Translation. Oncol., 9, 459 (2007),
- Yen-Revollo, J., et al.: Clin. Cancer Res., 14, 8 (2008),
- Spector, T., et al.: Clin. Colorect. Cancer, 9, 52 (2010),
