Poly(Ethylene Glycol) 聚乙二醇

CAS 25322-68-3 MFCD00081839

化学结构图

25322-68-3
SMILES:

化学属性

Refractive indexn/D 1.465 (20 °C)
Mol. FormulaH(OCH2CH2)nOH
Density1.125
Melting Point52-56
Flash Point|>240°(464°F)
TSCAYes
Autoignition Point581 °F
Vapor Density>;1 (vs air)
Vapor Pressure<;0.01 mmHg ( 20 °C)
Mol. Weight44.05
Stability对湿度敏感
pH:A

别名和识别编码

Synonym Alkapol peg-600 Carbowax 1000 Carbowax 10000 Carbowax 1540 Carsonon peg-4000 Lutrol® Macrogol 1,500 PEG Macrogol 3,000 PEG Macrogol 400 P.E.G. 1500 PEG PEG 聚乙二醇 PEG 20000 PEG 600 PEG 溶液 PEO Pluracol E-200 Pluracol E-600 Pluracol P-20 Poly(ethylene oxide) Poly(oxy-1,2 Polyaethylenglykole #1500 Polyaethylenglykole #238 Polyaethylenglykole #300 Polyethylene glycol 3000 monodisperse solution Polyethylene glycol 4000000 Polyglycol E-300 a alpha-Hydro-omega-hydroxyp {} { 聚乙二醇/聚环氧乙烷标准品 ReadyCal 套装 Mp 200-1′200′000 聚乙二醇标准品套装 Mp 400-40′000 聚氧乙烯 聚环氧乙烷
CAS Number25322-68-3
PubChem Substance ID87575025
MDL NumberMFCD00081839
EC Number500-038-2
Merck Number7568
Chemical NamePoly(Ethylene Glycol)
Beilstein Registry Number8402446
Chemical Name Translation聚乙二醇
Wiswesser Line Notation/*O2*/
LabNetwork Molecule IDLN03240061
Reaxys-RN8402446
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分类

  • Alphabetic, Analytical Standards, Analytical/Chromatography, Application CRMs, Certified Reference Materials (CRMs),
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Emulsifiers, Thickeners, Opacifiers, Essential Chemicals, Inorganic Salts, Solutions and Reagents,
  • {SNA} Core Bioreagents,
  • {SNA} Ess

产品应用

  • Usually used to modify therapeutic proteins and peptides to increase their solubility and lower their toxicity.

相关文献及参考

  • Catalyzes the reaction of potassium aryloxides with dichloromethane at room temperature to give good yields of diaryloxymethanes: J. Chem. Res. (Synop.), 503 (1995).
  • Merck: 14,7568

安全信息

WGK Germany1
Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Eyeshields, Gloves Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSTQ4041000
GHS Symbol
Hazard statements
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
  • H302 Harmful if swallowed 吞食有害
  • H311 Toxic in contact with skin 皮肤接触中毒
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P352+P312
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger Warning
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
Hazard Codes T
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R33 Danger of cumulative effects 有累积作用的危险
  • R52/53
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
Storage condition 密封阴凉干燥保存。 充氩保存
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8 gm/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 103,293,1951

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 34 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
   G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
   Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
   Volume(issue)/page/year: 2C,3847,1982

TYPE OF TEST            : LD50 - Lethal

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 36 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
   G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
   Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
   Volume(issue)/page/year: 2C,3847,1982

TYPE OF TEST            : LD50 - Lethal dose

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 50900 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   ARZNAD Arzneimittel-Forschung.

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 416 mg/kg/Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - other reproductive system tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   15,252,1961

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION           : 50 pph
REFERENCE :
   DKBSAS Doklady Biological Sciences (English Translation).  Translation of
   DANKAS: Biological Section. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.112-    1957-  Volume(issue)/page/year: 240,228,1978

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 100 gm/L
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 72,4288,1975

其他信息

  • 聚氧乙烯(PEO)是一种水溶性的聚氧乙烯树脂。
  • 有轻微特殊气味。微有吸湿性。遇热易熔化。溶于水和乙醇
  • 聚氧化乙烯(PEO)是一种水溶性树脂。相对分子质量200~20000的产品被称为聚乙二醇(PEG),它们是粘性液体或蜡状固体:分子相对质量大于1x105的产品被称为聚氧化乙烯,PEO聚氧化乙烯是白色可流动粉末,分子结构为(CH2CH2O),此类树脂活性端基的浓度较低,没有明显的端基活性。

系列性分类


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