Paraformaldehyde 多聚甲醛
CAS 30525-89-4 MFCD00133991
化学结构图
SMILES: C=O
化学属性
| Mol. Weight | 30.03 (as monomer) |
|---|---|
| Mol. Formula | (CH2O)n |
| Density | 0.88 |
| Melting Point | 120-170 |
| Flash Point | 71°(159°F) |
| TSCA | Yes |
| Autoignition Point | 572 °F |
| Vapor Density | 1.03 (vs air) |
| Vapor Pressure | <;1.45 mmHg ( 25 °C) |
| Stability | 对湿度敏感 |
别名和识别编码
| Synonym | 聚氧亚甲基 Flo-Mor 固体甲醛 Paraform Aldacide 聚合甲醛,仲甲醛 Polyoxymethylene 多聚甲醛 Formagene |
|---|---|
| CAS Number | 30525-89-4 |
| PubChem Substance ID | 87574298 |
| MDL Number | MFCD00133991 |
| Reaxys-RN | 1209228 |
| Merck Number | 7025 |
| Beilstein Registry Number | 102769 |
| EC Number | 200-001-8 |
| Chemical Name | Paraformaldehyde |
| Chemical Name Translation | 多聚甲醛 |
| Wiswesser Line Notation | /*VH*/ X |
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分类
- {SNA} Aldehydes,
- {SNA} Aldehydes, Building Blocks, C1 to C6, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
- {SNA} Apoptosis Reagents, Apoptosis and Cell Cycle, Core Bioreagents, Fixatives, General Reagents, Life Science Reagents for Immunohistochemistry (IHC), Life Science Reagents for RNAi, Optimization Reagents, Other Apoptosis Related Reagents, Research Essentials, Tissue Processing, X-Ray Crystallography, 分子生物学, 细胞信号转导和神经科学, 细胞生物学, 蛋白质组学, 蛋白质结构分析, 血液学和组织学
- Apoptosis Reagents,
产品应用
- 有机合成，杀菌剂，熏蒸剂，消毒剂。多聚甲醛为高甲醛含量的固态甲醛，呈固体颗粒状；便于贮存和运输。在较高的温度下能变成甲醛蒸气，易于代替高浓度甲醛参与各种反应，有利于化工；制药等化学合成及其他工业领域的应用，特别是在要求使用无水甲醛作原料的合成方面，用途广泛。
相关文献及参考
- See also Formaldehyde, A16163 and 1,3,5-Trioxane, A15639 .
- Reaction with dialkyl phosphites gives hydroxymethyl phosphonates, which, after O-protection, undergo the Horner-Wadsworth-Emmons reaction to give enol ethers. See, e.g.: Org. Synth. Coll., 7, 160 (1990).
- For use in the preparation of di-t-butyl methylenemalonate, see Di-tert-butyl malonate, A12774. For the direct ɑ-methylenation of ketones, see N-Methylanilinium trifluoroacetate, A17781.
- Merck: 14,7025
- In the presence of HCl, aromatics undergo chloromethylation. For reviews, see: Org. React., 1, 63 (1942); Russ. Chem. Rev., 46, 891 (1977). Caution! carcinogenic bis(chloromethyl) ether is formed in these reactions. In combination with Hydrobromic acid, A14475, the bromomethylation of aromatics has been effected: J. Org. Chem., 58, 1262 (1993). The same combination also N-bromomethylates phthalimide and other imides: Synlett, 933 (1994).
- Reaction with dialkyl phosphites gives hydroxymethyl phosphonates, which, afte
- For use in preparation of Mannich bases, see: Org. Synth. Coll., 3, 305 (1955); 4, 281 (1963). For reviews, see: Org. React., 1, 303 (1942); Synthesis, 703 (1973); Tetrahedron, 46, 1791 (1990).
- Formaldehyde monomer, generated by thermolysis, has been used for the ɑ-hydroxymethylation of dilithiated carboxylic acids. Dehydration of the products affords ɑ-alkyl acrylic acids: J. Org. Chem., 37, 1256 (1972). Monomeric formaldehyde can also be prepared as a THF solution by dehydration with p-Toluenesulfonic anhydride, L00160, and co-distillation of the monomer with the solvent: Synlett, 704 (1990). The use of anhydrous molecular formaldehyde for hydroxymethylation reactions has been discussed: Synlett, 227 (1990).
- Merck: 14,7025 Beilstein:1,566
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H351 Suspected of causing cancer 怀疑致癌
- H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
- H318 Causes serious eye damage 严重伤害眼睛
- H302+H332
- H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
- H228 Flammable solid 易燃固体
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P301+P312+P330
- P302+P350
- P302+P352+P333+P313
- P304+P340+P312
- P305+P351+P338
- P305+P351+P338+P310
- P337+P313
- P370+P378
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S24 Avoid contact with skin 避免皮肤接触；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R11 Highly flammable 非常易燃
- R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1070 mg/m3/4H TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534623
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 10000 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Skin and Appendages - corrosive (after topical exposure) Nutritional and Gross Metabolic - body temperature decrease REFERENCE : BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 4,308,1969
TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - rat Embryo DOSE/DURATION : 2200 ng/plate REFERENCE : JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 1,190,1981
其他信息
- HazardClass:4.1
- 系甲醛的线形聚合物，有甲醛气味，对湿敏感，加热则分解为甲醛和水，在沸水分解为甲醛的水溶液，溶于冷水、稀碱和稀酸溶液，不溶于醇和醚，其高度聚合物不溶于水。易燃。低毒，半数致死量(大鼠，经口)800mg/kg。有刺激性。
