CAS 111-30-8 MFCD00007025-Glutaraldehyde 戊二醛 TAO{mole}

Glutaraldehyde 戊二醛

CAS 111-30-8 MFCD00007025

化学结构图

SMILES: O=CCCCC=O

化学属性

Mol. Formula	C5H8O2
Mol. Weight	100
Density	1.106
Refractive index	n20/D 1.42
TSCA	Yes
Melting Point	-6 °C
Boiling Point	101 °C
Solubility	溶于热水乙醇、氯仿、冰醋酸、乙醚。
Vapor Density	1.05 (vs air)
Vapor Pressure	15 mmHg ( 20 °C)
Flash Point	100°C
Stability	对光, 空气及热敏感

别名和识别编码

Chemical Name	Glutaraldehyde
Synonym	1 1,3-Diformylpropane 1,3-diformalpropane 1,5-Pentanedial 1,5-Pentanedione 1,5-戊二醛 1,5-戊二醛五碳双缩醛溶液 1,5-戊二醛五碳双缩醛溶液戊二醛溶液 5-戊二醛 5-戊二醛; 五碳双缩醛; 胶醛 Aldehyd glutarowy Alhydex Cidex Cidex 7 FIXATIVE 15960 FIXATIVE 15970 FIXATIVE 15980 Glutaral Glutaraldehyd Glutaraldehyde Glutardialdehyde Glutaric dialdehyde solution NCI-C55425 PANTHANEDIAL Sonacide aldesen 五碳双缩醛五碳双缩醛溶液戊二醛戊二醛溶液戊二醛(25%水溶液) 戊二醛(50%) 戊二醛,溶液戊二醛溶液,25%
CAS Number	111-30-8
PubChem Substance ID	3485
Beilstein Registry Number	605390
MDL Number	MFCD00007025
Reaxys-RN	605390
Merck Number	4472
EC Number	203-856-5
Chemical Name Translation	戊二醛
Wiswesser Line Notation	VH3VH
LabNetwork Molecule ID	LN00220666
InChI	InChI=1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2

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产品应用

戊二醛是仅次于乙二醛的最重要的饱和直链脂肪族二元醛。戊二醛被誉为第三代化学灭菌剂，同时还是一种优良的鞣革剂、蛋白质交联剂、高效杀菌消毒剂、生物酶和细胞的组织固化剂。广泛应用于医药、卫生、石油化工、轻工业部门以及科研领域。

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H302 Harmful if swallowed 吞食有害
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
H335 May cause respiratory irritation 可能导致呼吸道刺激
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H318 Causes serious eye damage 严重伤害眼睛
H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H312 Harmful in contact with skin 皮肤接触有害
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
H301+H331
H302+H332
H301 Toxic if swallowed 吞食有毒
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Hazard Codes 8 T,N T,N,Xn

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P310
P301+P310+P330
P301+P330+P331+P310
P303+P361+P353
P304+P340+P310
P304+P340+P311
P305+P351+P338
P305+P351+P338+P310
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P342+P311
P403+P233
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

RTECSMA2450000

UN Number 2922 2927

Risk Statements

R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
R22 Harmful if swallowed 吞咽有害
R23 Toxic by inhalation 吸入有毒
R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
R34 Causes burns 会导致灼伤
R37 Irritating to respiratory system 刺激呼吸道
R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
R42/43
R50 Very toxic to aquatic organisms 对水生生物极毒

Safety Statements

S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Packing GroupII

Storage condition 密封保存密封保存,储存温度2-8°C 储存温度2-8°C，充氩保存 2-8°C

Hazard Class6.1/8

Warnings 危化品目录(2015)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 560 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 11/4/1971

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 480 mg/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than le

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 19,503,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,395,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - duck
DOSE/DURATION           : 820 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - food intake (animal)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Cl

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 1 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 193,21,1988

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bird - chicken Leukocyte
DOSE/DURATION           : 8 pph
REFERENCE :
   CELLB5 Cell (Cambridge, Mass.).  (MIT Press, 28 Carleton St., Cambridge, MA
   02142)  V.1-    1974-  Volume(issue)/page/year: 5,45,1975

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 2500 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 283,131,1992

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 148,25,1985

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION           : 50 mmol/L
REFERENCE :
   ECREAL Experimental Cell Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.10-    1950-  Volume(issue)/

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 umol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   17(Suppl 19),71,1991

TYPE OF TEST            : Sister chromatid e

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 8 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 22,51,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 50 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 22,51,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 875 mg/kg
SEX/DURATION            : male 35 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 12,11,1976

Restrict 危险品

其他信息

用途七:戊二醛是仅次于乙二醛的最重要的饱和直链脂肪族二元醛。戊二醛被誉为第三代化学灭菌剂，同时还是一种优良的鞣革剂、蛋白质交联剂、高效杀菌消毒剂、生物酶和细胞的组织固化剂。广泛应用于医药、卫生、石油化工、轻工业部门以及科研领域。
用途一:杀菌消毒剂、鞣革剂、木材防腐剂，药物和高分子合成原料等。
非凝固型固定剂:戊二醛能与蛋白质分子的氨基和肽键连接形成交连；是最常用的非凝固型固定剂。可以部分保持酶和蛋白质的活性。固定能力比甲醛强。常用于电镜制片的固定；用缓冲液配制。
方法三:由丙烯醛与乙烯基乙醚环合为2-乙氧基-3,4-二氢吡喃加入反应锅内，密闭搅拌1h，静置半小时，即得戊二醛溶液，将乙醇蒸出，使成25%溶液。或加碳酸氢钠中和，以食盐饱和，然后用乙醚提取2次，回收乙醚后，减压蒸馏，收集75-81℃（2kPa）馏分，获得纯的产品。另外，将吡啶还原成二氢吡啶，再用羟胺处理得到戊二肟，最后用亚硝酸钠和盐酸使戊二肟反应为戊二醛。该法转率可达90%。
上游原料:乙烯基乙醚 --> 丙烯醛 --> 2,6-二甲基-1,4-二氢-3,5-吡啶二羧酸二乙酯 --> 3,4-二氢-2H-吡喃 --> 2-乙氧基-3,4-二氢吡喃
用途五:戊二醛用于消毒、制药、鞣革，用作电子显微镜及彩色显像管的坚
含量分析:0.5mol/L盐酸胲溶液的制备取盐酸胲35.0g于1L容量瓶中，用水溶解后定容混合。 0.5mol/L三乙醇胺液的制备取98%三乙醇胺65ml(74g)，放人一1L容量瓶中，用水稀释后定容并混合。操作将盐酸胲溶液(足够供分析空白和试样的量)中和至pH为3.60。用一适当的滴定器用三乙醇胺溶液进行滴定(注意：在中和和分析过程中始终保持同样的搅拌速度)。于二只滴定杯中各加已中和的盐酸胲溶液65.0ml，在每只杯上装一涂有聚四氟乙烯的搅拌器，经自动滴定管，在每一只滴定杯中加入已中和的三乙醇胺液30.8ml，加盖，搅拌。用一已称重的移液管，吸取一定量的试样，约等于戊二醛300mg，加于一杯子中。经充分混合后，将试样液和空白样液在室温下至少维持60min，但不超过90min。用0.5mol/L盐酸将试样和空白样滴定至pH为3.60，测定终点电位差。按下式计算试样中戊二醛质量百分含量：戊二醛(%)=[c(B-A)(0.05006)/W]100 式中 B和A——分别为空白和试样液所耗盐酸的体积，ml； c——盐酸的浓度，mol/L； 0.05006——戊二醛摩尔质量，g； W——?试样质量，g。
用途六:戊二醛被誉为继甲醛和环氧乙烷消毒之后化学消毒灭菌剂发展史上的第三个里程碑。作为生产戊二醛系列杀菌剂的原液，戊二醛(111-30-8)系列杀菌剂具有甲醇含量低，无致歧变、无积毒的特点，广泛用于消毒灭菌、制药等行业. 戊二醛(111-30-8)属高效消毒剂，具有广谱、高效、低毒、对金属腐蚀性小、受有机物影响小、稳定性好等特点。适用于医疗器械和耐湿忌热的精密仪器的消毒与灭菌。其灭菌浓度为2%，市售戊二醛主要有：2%碱性戊二醛和2%强化酸性戊二醛两种。碱性戊二醛常用于医疗器械灭菌，使用前应加入适量碳酸氢钠，摇匀后，静置1小时，测定pH值。PH在7.5-8.5时，戊二醛的杀菌作用最强。戊二醛杀菌(111-30-8)是其单体的作用，当溶液的pH达到6
所属类别三:皮革化学品: 戊二醛
方法二:将乙烯基乙醚和丙烯醛加入反应釜，冷却至5℃，加入溴化锌，密闭搅拌，缓慢升温，并在48～53℃下保温3h。冷却至25"E：后，用水洗涤分层，蒸馏有机层，收集80～82℃(10．67kPa)的馏分，即为2-乙氧基-3，4
食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称允许使用该种添加剂的食品中文名称添加剂功能最大允许使用量（g/kg）最大允许残留量（g/kg）五碳双缩醛食品食品工业用加工助剂 / 一般应在制成最后成品之前出去，有规定食品中残留量的除外
灭火剂:泡沫、二氧化碳、砂土
可燃性危险特性:水溶液不燃; 受热分解放出气体可燃; 火场放出辛辣刺激烟雾
Alfa Aesar:戊二醛,50%aq.soln. Glutaraldehyde, 50% aq. soln.(111-30-8)