CAS 141-43-5 MFCD00008183-Ethanolamine 乙醇胺 TAO{mole}

Ethanolamine 乙醇胺

CAS 141-43-5 MFCD00008183

化学结构图

SMILES: NCCO

化学属性

Mol. Formula	HOCH2CH2NH2
Mol. Weight	61
Refractive index	1.4520 to 1.4570
Boiling Point	170
Density	1.012
Melting Point	10-11
Flash Point	93°C(lit.)
TSCA	Yes
Autoignition Point	1436 °F
Vapor Density	2.1 (vs air)
Vapor Pressure	0.2 mmHg ( 20 °C)
Solubility	Soluble in water (1 g/l at 20 °C), methanol, acetone, chloroform, and glycerol.
Stability	对湿度敏感
pH	:A

别名和识别编码

Chemical Name	Ethanolamine
Synonym	(2-hydroxyethyl)amine 1-amino-2-hydroxy ethane 2-AMINOETHANOL 2-Amino-1-ethanol 2-Aminoaethanol 2-AminoethanoI 2-Aminoethanol, 2-Aminoethyl alcohol,Monoethanolamine 2-Aminoäthanol 2-amino-ethanol 2-aminoethanol 2-氨基乙基醇 2-氨基乙醇 ETA MEA 90 MEA-LCI 2-氨基乙基醇 2-氨基乙醇 ETA MEA 90 MEA-LCI MEA 单乙醇 COLAMINE Colamine Ethanolamine GLYCINOL H-GLYCINOL MEA (alcohol) MO Monoaethanolamin Monoethanol amine Monoäthanolamin beta-Aminoethyl alcohol {} {} {} {} {Chem {} {} {} {} {Chemicalb {} {} {} {} {uni 乙醇胺乙醇胺溶液单乙醇胺單乙醇胺羟乙基胺
CAS Number	141-43-5
PubChem Substance ID	87561950
EC Number	205-483-3
Beilstein Registry Number	505944
MDL Number	MFCD00008183
Reaxys-RN	505944
Merck Number	3727
Chemical Name Translation	乙醇胺
Wiswesser Line Notation	Z2Q
LabNetwork Molecule ID	LN00189265
InChI	InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2

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产品应用

溶剂。有机合成, 从气体中除去二氧化碳及硫化氢。气相色谱固定液(最高使用温度50℃，溶剂为乙醚)，用于分离低碳醇类、吡啶及其衍生物。

安全信息

GHS Symbol

WGK Germany1

Hazard Codes 8 C T T,C

Hazard statements

H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
H335 May cause respiratory irritation 可能导致呼吸道刺激
H302+H312+H332
H227 Combustible liquid 可燃液体
H331 Toxic if inhaled 吸入中毒
H311 Toxic in contact with skin 皮肤接触中毒
H301 Toxic if swallowed 吞食有毒
H370 Causes damage to organs 导致器官损伤
H226 Flammable liquid and vapour 易燃液体和蒸气

Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSKJ5775000

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312+P330
P301+P330+P331+P310
P303+P361+P353
P303+P361+P353+P310+P363
P304+P340+P310
P305+P351+P338
P305+P351+P338+P310
P308+P311
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P403+P235
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R10 Flammable 易燃
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R34 Causes burns 会导致灼伤
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
R52/53

UN Number 2491

Storage condition Air Sensitive & Hygroscopic 密封保存。充氩保存 Store at RT.

Packing GroupIII

Hazard Class8

Warnings 危化品目录(2015)

TYPE OF TEST            : LC - Lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : >2420 mg/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 23(9),55,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1720 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   42,417,1977

TYPE OF TEST            : LC - Lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2420 mg/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 23(9),55,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   KBMEAL Kosmicheskaya Biologiya i Meditsina.  Space Biology and Medicine.
   (Mos

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   BZARAZ Biologicheskii Zhurnal Armenii.  Biological Journal of Armenia. (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.19-    1966-
   Volume(issue)/page/year: 39,422,1986

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CYGEDX Cytology and Genetics (English Translation).  Translation of TGANAK.
   (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011)  V.8-    1974-
   Volume(issue)/page/year: 21(6),29,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2250 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFF

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4500 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   40,158,1997

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 500 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   6,403,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2250 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   31,117,1996

Restrict 危险品

其他信息

用途五:一乙醇胺主要用作合成树脂和橡胶的增塑剂、硫化剂、促进剂和发泡剂、以及农药、医药和染料的中间体。也是合成洗涤剂、化妆品的乳化剂等的原料。纺织工业作为印染增白剂、抗静电剂、防蛀剂、清净剂。也可用作二氧化碳吸收剂、油墨助剂、石油添加剂。一乙醇胺广泛用作从各种气体（如天然气）中提取酸性组分的净化液。由一乙醇胺盐酸盐环合、中和可制得六水合哌嗪。一乙醇胺盐酸盐经氯化亚砜氯代，再被硫代硫酸钠取代，可制得β-氨基乙基硫代硫酸盐。这是一种染料中间体，用于生产缩聚翠蓝13G。一乙醇胺与二硫化碳反应可制得在橡胶和制药工业中有应用的中间体硫基噻唑啉。
有吸湿性和氨臭；能与水、乙醇和丙酮等混溶，微溶于乙醚、四氯化碳、乙醇和氯仿；能吸收二氧化碳和硫化氢；与无机酸和有机酸反应生成酯；均具强碱性，微溶于苯。低毒，半数致死量(大鼠，经口)10.2g/kg。
有吸湿性和氨臭；能与水、乙醇和丙酮等混溶，微溶于乙醚、四氯化碳、乙醇和氯仿；能吸收二氧化碳和硫化氢；与无机酸和有机酸反应生成酯；均具强碱性，微溶于苯。低毒，半数致死量(大鼠，经口)10.8g/kg。
有吸湿性和氨臭；能与水、乙醇和丙酮等混溶，微溶于乙醚、四氯化碳、乙醇和氯仿；能吸收二氧化碳和硫化氢；与无机酸和有机酸反应生成酯；均具强碱性，微溶于苯。低毒，半数致死量(大鼠，经口)10.5g/kg。
所属类别二:农药中间体: 杀虫剂中间体: 氨基甲酸酯类杀虫剂
有吸湿性和氨臭；能与水、乙醇和丙酮等混溶，微溶于乙醚、四氯化碳、乙醇和氯仿；能吸收二氧化碳和硫化氢；与无机酸和有机酸反应生成酯；均具强碱性，微溶于苯。低毒，半数致死量(大鼠，经口)10.3g/kg。
急性毒性:口服- 大鼠 LD50: 1720 毫克/ 公斤; 口服- 小鼠 LD50: 700 毫克/ 公斤
毒性分级:中毒
方法二:由环氧乙烷和氨水在30～40℃下、70.1～304kPa下缩合而成，其为单、二、三乙醇胺的混合液，在90～120℃下脱水、浓缩，然后于精馏塔中减压蒸馏，截取168～174℃馏分而得。
灭火剂:泡沫、二氧化碳、干粉、雾状水
上游原料:氨 --> 曙光红(四溴荧光素) --> 三乙醇胺 --> 二乙醇胺 --> 聚醚 --> 结晶紫 --> 磷脂 --> 胆碱
Acros Organics:乙醇胺 Ethanolamine, 99
有吸湿性和氨臭；能与
方法一:乙醇胺可由氨与环氧乙烷反应制得。环氧乙烷、氨水溶液和循环氨一起进入不锈钢制成的反应器，内设冷却装置，反应温度30～40℃，反应压力0.7～3MPa。反应产物进入脱氨塔，脱除的氨返回氨吸收器制备氨水溶液，塔底产物经蒸发浓缩和干燥脱水即得粗乙醇胺。采用减压蒸馏将一乙醇胺、二乙醇胺和三乙醇胺分别蒸出，纯度可达到98％～99％，环氧乙烷的转化率接近100％，乙醇胺的收率为95％左右。另外，尚有少量副产物聚醚生成，在原料中配入少量的二氧化碳可以减少副产物的生成。
用途三:乙醇胺又名2-氨基乙醇、2-羟基乙胺和单乙醇胺。乙醇胺是制备氨基甲酸酯类杀虫剂双氧威的中间体，还广泛用作从各种气体(如天然气)中提取酸性组分的净化液。由乙醇胺与脂肪酸生成的烷基醇酰胺是有效的泡沫增效剂。乙醇胺还是乳化剂的中间体，用于纺织工业作为抗静电剂、防蛀剂、清洁剂。由乙醇胺盐酸盐环合、中和可制得六水合哌嗪，哌嗪以其磷酸盐或柠檬酸盐的形式可作为驱肠虫药。
所属
下游产品:2-(二苯基膦基)乙胺 --> N-(2-羟基乙基)-2-[4-(2-甲基丙基)苯基]丙酰胺 --> 荧光增白剂 85 --> 2-溴乙胺氢溴酸盐 --> 半胱胺盐酸盐 --> 氨氯地平 --> 3-吗啉酮 --> 丙草胺 --> 荧光增白剂 --> (乙酰氨基){[
防护措施:乙醇胺的稀溶液具有非常弱的碱性和刺激性，随着其浓度的增大，对眼、皮肤和粘膜有刺激性。小鼠经口LD50为700mg/
Acros Organics:乙醇胺 Ethanolamine, 99%(141-43-5)
Alfa Aesar:乙醇胺,ACS,99+% Ethanolamine, ACS, 99+%(141-43-5)