CAS 7803-49-8 MFCD00044522-Hydroxylamine 羟胺 TAO{mole}

Hydroxylamine 羟胺

CAS 7803-49-8 MFCD00044522

化学结构图

SMILES: NO

化学属性

Mol. Formula	H3 N O
Mol. Weight	33.03
Density	1.078 g/mL at 25 °C
Boiling Point
Vapor Pressure	9 mmHg ( 40 °C)
Refractive index	1.3940
Flash Point	None
TSCA	Yes
Melting Point	No Data Available
Appearance	不稳定的白色大片状或针状结晶。极易吸潮，极易溶于水。当浓度为100%、10%、20%、30%、40%、50%时水溶液的相对密度分别为：1.2040、1.0192、1.0410、1.0637、1.0875、1.1122。该品在热水中分解，微溶于乙醚、苯、二硫化碳、氯仿。熔点32.05℃，沸点70℃（1.33kPa）。

别名和识别编码

Chemical Name	Hydroxylamine
Synonym	FH-50 FH-50TM H₂NOH HDA HYDROXYLAMINE HYDROXYLAMINE SOLUTION, ~50% IN WATER HYDROXYLAMINE, 50 WT. % SOLUTION IN WATE R HYDROXYLAMINE, 99.999%, 50 WT. SOLUTION IN WATER HYDROXYLAMINE,FREEBASE,50%AQUEOUSSOLUTION HYDROXYLAMINE: 50% AQUEOUS SOLUTION Hydroxyamine Hydroxylamine Solution (50 wt. % in H2O) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydroxylamine Solution(50 wt. % in H2O) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL Number	MFCD00044522
CAS Number	7803-49-8
PubChem Substance ID	787
EC Number	232-259-2
Merck Number	14,4828
Beilstein Registry Number	1098214
Chemical Name Translation	羟胺
Reaxys-RN	3587190
Wiswesser Line Notation	ZQ
LabNetwork Molecule ID	LN01309816
InChI	InChI=1S/H3NO/c1-2/h2H,1H2

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安全信息

WGK Germany3

Precautionary statements

P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P337+P313
P234 Keep only in original container. 只保留在原来的容器中。
P403+P233
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P273 Avoid release to the environment. 避免释放到环境中。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338
P303+P361+P353
P304+P340
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P308+P311
P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
P301+P330+P331
P201 Obtain special instructions before use. 使用前获取专门指示。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P405 Store locked up. 上锁保管。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P333+P313
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。

Signal word Danger

Hazard statements

H290 May be corrosive to metals 可能腐蚀金属。
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H302 Harmful if swallowed 吞食有害
H335 May cause respiratory irritation 可能导致呼吸道刺激
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H351 Suspected of causing cancer 怀疑致癌
H318 Causes serious eye damage 严重伤害眼睛
H315 Causes skin irritation 会刺激皮肤
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
H302+H312
H371 May cause damage to organs 可能导致器官损伤

RTECSNC2975000

GHS Symbol

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Packing GroupIII

UN Number 3082 UN3266 UN 3082 9/PG 3 3266

Risk Statements

R22 Harmful if swallowed 吞咽有害
R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
R48/20/21/22
R50 Very toxic to aquatic organisms 对水生生物极毒
R5 Heating may cause an explosion 加热会引起爆炸
R48/22
R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害

Safety Statements

S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S47 Keep at temperature not exceeding ... °C (to be specified by the manufacturer) 保持温度不超过……°C（由生产厂家指定）；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S46 If swallowed, seek medical advice immediately and show this container or label 食入时，立即求医并出示容器/标签；
S57 Use appropriate containment to avoid environmental contamination 使用适当容器避免环境污染；
S22 Do not breathe dust 不要吸入粉尘；

Hazard Codes Xn;N Xn,N

Hazard Class8

Storage condition +4°C 0-10°C 4 4℃

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   6,160,1952

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 29 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 119,444,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 165,30,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 59 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   26,1448,1966

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 20 mmol/L
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   148,507,1965

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 pph
REFERENCE :
   AGACBH Agents and Actions, A Swiss Journal of Pharmacology.  (Birkhaeuser
   Verlag, POB 133, CH-4010 Basel, Switzerland)  V.1-    1969/70-
   Volume(issue)/page/year: 4,286,1974

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 400 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 22,223,1974

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 93,447,1982

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 23 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 16,165,1972

TYPE OF TEST            : Mutation in microorgan

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 pph
REFERENCE :
   AGACBH Agents and Actions, A Swiss Journal of Pharmacolo

TYPE OF TEST

{hazard_c

其他信息

可燃性危险特性:受热分解有毒氮氧化物烟雾
Alfa Aesar:羟胺,50%水溶液 Hydroxylamine, 50% aq. soln.(7803-49-8)
上游原料:乙醇钠 --> 1-氨基乙醇 --> 磷酸羟胺
毒性分级:高毒
类别:腐蚀物品
F:4.8
灭火剂:水、二氧化碳、砂土
羟胺价格(试剂级):更新日期产品编号产品名称包装价格 2010/05/25 B22202 羟胺, 50% 水溶液 Hydroxylamine, 50% aq. soln. 500ml 1305元 2010/05/25 B22202 羟胺, 50% 水溶液 Hydroxylamine, 50% aq. soln. 100ml 413元
急性毒性:腹腔-大鼠 LD50： 59 毫克/公斤；腹腔- 小鼠 LD50: 60 毫克/ 公斤
蒸气压:9 mm Hg ( 40 °C)
MOL 文件:7803-49-8.mol
Sigma Aldrich:7803-49-8(sigmaaldrich)
用途一:在有机合成中用作还原剂。
方法一:用盐酸羟胺乙醇溶液加乙醇钠，将析出的氢氧化钠迅速滤出，滤液冷至-18℃结晶，过滤，得羟胺。将磷酸羟胺加热蒸馏（1.73kPa下操作），收集135-137℃馏分，亦可得羟胺粗品。
储运特性:库房通风低温干燥; 与可燃物分开存放
爆炸物危险特性:高温爆炸