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• 试剂商城
• 直接询价

分类

• {SNA} Derivatization Re
• {SNA} C-X Bond Formation (Non-Ha
• {SNA} Atomic Absorption Spectroscopy (AAS), High Purity Reagents for Trace Analysis, Matrix Modifiers, Buffers and Reducing Reagents for AAS, Minerals, Nutritional (other than carbohydrates, fats, proteins), Reagents for Extraction Analysis, Reagents for Inorganic Trace Analysis, Reducing Agents (for Hydride AAS), Spectroscopy, Trace Analysis Reagents & Solvents,
• {SNA} Bioactive Small Molecules,
• {SA} Analytical Reagents, Analytical/Chromatography, Bioactive Small Molecules, Cell Biology, Derivatization Reagents, Derivatization Reagents HPLC, H, UV-VIS
• {SNA} C-X Bond Formation (Non-Halogen), Chemical Synthesis, Other Non-Halogen Reagents for C-X Bond Formation, Synthetic Reagents
• {SNA} Analytical Reagents,
• {SNA} Anal

产品应用

• 无机分析还原剂，络合剂，电分析去极剂，脂肪酸和肥皂的抗氧剂，分析甲醛、樟脑和葡萄糖等，有机分析检验醛和酮类，微量分析磺酸，钢铁中镁成分测定，有机合成制备肟类。彩色影体洗印。催化剂。溶胀剂。共聚反应阻聚剂。

相关文献及参考

• Merck 14 ,4828
• For a brief feature on
• For a one-pot synthesis of pyrazoles from aldehydes by cyclization of the intermediate oxime in acidic medium with potassium dihyrogen phosphate, see: Tetrahedron Lett., 47, 43 (2006).
• Merck:14,4828
• For examples of preparation of oximes from carbonyl compounds, see: Org. Synth. Coll., 2, 70, 313 (1955); 7, 149 (1990). Dehydration of aldoximes is a valuable route to nitriles. The preparation of an oxime, and dehydration with acetic anhydride, are exemplified for veratraldehyde: Org. Synth. Coll., 2, 622 (1943). For other methods of dehydrating oximes to nitriles, see Benzaldoxime, A12053. Procedures for the one-pot conversion of aldehydes to nitriles, without isolation of the intermediate oxime, include: refluxing the aldehyde with hydroxylamine hydrochloride in formic acid/ sodium acetate: J. Chem. Soc., 1564 (1965); formic acid alone: Synthesis, 112 (1979); in pyridine and toluene, with azeotropic water removal: Synthesis, 190 (1982); in DMF (reflux; aromatics only): Z. Chem., 15, 302 (1975); heating in NMP at 110-115o, effective for aromatic and aliphatic substrates; under these conditions, DMF gave only 20-30% conversion: Synthesis, 586 (1999). A more recent ambient temperature one-pot procedure utilizes DBU in combination with ethyl dichlorophosphate: Synlett, 1317 (2007).
• For a brief feature on uses of this reagent in Organic synthesis, see: Synlett, 1326 (2007).
• For a

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   21,635,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 141 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0555279

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 20 mmol/L
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   148,507,1965

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 500 ug/plate
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,873,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 200 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 8,451,1969

T

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 2 mol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 24,245,1974

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 1 mol/L
REFERENCE :
   VIRLAX Virology.  (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
   V.1-    1955-  Volume(issue)/page/year: 81,192,1977

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Primate - monkey Kidney
DOSE/DURATION           : 25 mg/L
REFERENCE :
   ECREAL Experimental Cell Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.10-

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其他信息

• TCI Shanghai:盐酸羟胺 Hydroxylamine Hydrochloride,>;97.0%(T)(5470-11-1)
• F:21
• Acros Organics:羟胺盐酸盐 Hydroxylaminehydrochloride,99+%(5470-11-1)
• 方法二:肟化法首先在合成釜中加入一定量的水，在搅拌下加入一定量的亚硝酸钠，分次加入一定量的焦亚硫酸钠，然后用硫酸酸化。酸化后的料液送入水解釜，加入一定量的丙酮，然后加入液碱中和。把中和液吸入蒸馏釜，蒸馏出丙酮肟。将丙酮肟和一定配比的盐酸加入成盐浓缩釜中进行反应，生成盐酸羟胺和丙酮。丙酮回收供水解用。盐酸羟胺经浓缩、冷却结晶、离心分离、干燥，制得盐酸羟胺成品。其 Na2S2O5+H2O→2NaHSO3 NaNO2+2NaHS3→HON(SO3Na)2+NaOH NaOH+H2SO4→NaHSO4+H2O
• MOL 文件:5470-11-1.mol
• 上游原料:亚硝酸钠 --> 硫酸二甲酯 --> Α-球蛋白 --> 焦亚硫酸钠 --> 硝基甲烷 --> 丙酮肟
• 外观性质:白色晶体, 易潮解。
• MSDS 信息:盐酸羟胺(5470-11-1).msds
• 用途六:无机分析还原剂，络合剂，电分析去极剂，脂肪酸和肥皂的抗氧剂，分析甲醛、樟脑和葡萄糖等，有机分析检验醛和酮类，微量分析磺酸，钢铁中镁成分测定，有机合成制备肟类。彩色影体洗印。催化剂。溶胀剂。共聚反应阻聚剂。
• 下游产品:2-氨基-5,6-二氯苯甲酸 --> 5-甲基-3-异噁唑羧酸乙酯 --> 5-甲基-4-异恶唑磺酰氯 --> 5-氨基-4-异噁唑羧酸乙酯 --> 4-氨基四氢吡喃盐酸盐 --> 6-溴靛红 --> 3,4,5-三甲氧基苄胺 --> 3-氨基-4-甲基噻吩-2-甲酸甲酯 --> 4-氨基-1,2,5-噁二唑-3-甲腈 --> 3-(2,6-二氯苯基)-5-甲基异恶唑-4-羧酸 --> 醋酸去氢表雄酮 --> 6-氨基-2-甲基-2-庚醇 --> 5-甲基-3-苯基异噁唑 --> 2,6-二氰基-4-硝基苯胺 --> 1-(2,6-二甲基苯氧基)-2-丙酮肟 --> 甲乙酮肟 --> 3-甲基-5-苯基-4-异恶唑甲酸 --> 4-甲基硫代苄胺 --> 3-(2-氯苯基)-5-甲基-4-异恶唑甲酰氯 --> 苯甲酰胺肟 --> 2-吡啶基偕胺肟 --> 顺-5-氯-2-甲氧基-4-(甲基氨基)-N-[2-甲基-2-(苯基甲基)-3-吡咯烷基]苯甲酰胺 --> 3-(2-氯苯基)-5-甲基-4-异恶唑羧酸 --> 艾捉非尼 --> 孕甾-5-烯-20炔-3,17-二醇 --> 5-甲基-3-苯基-4-异唑甲酰氯 --> 4-吡啶基偕胺肟 --> 3-吡啶基偕胺肟 --> 3-甲基噻吩-2-腈 --> N-羟基琥珀酰亚胺磺酸钠盐 --> 二联苯乙二醛肟 --> 3Β-乙酰氧基-5Α-氯雄甾(烷)-6Β-醇-17-酮 --> 3，4-二甲氧基苄腈 --> 1,3-二甲基-5-苯氧基-1H-吡唑-4-甲醛肟 --> 5-甲基-3-苯基异恶唑-4-羧酸乙酯
• 海关编码:28251000
• 用途五:本品用于彩色照相和影片的洗印。有机合成工业中作还原剂，制备肟类及抗癌药和磺胺药。在医药方面还用于生产新诺
• 常规方法:采用内层衬塑料袋，中层衬纸袋，外层用聚乙烯的编织袋，再用木桶或纸桶包装，每袋25kg。本品易吸潮，加热时可深度分解，故需密封存放于干燥处，防潮、防热。按有毒物品规定贮运。
• 方法三:1.亚硝酸钠合成法（肟化法）将水加入反应釜，搅拌下加入亚硝酸钠，分次加入焦亚硫酸钠，然后用硫酸酸化。将酸化后的物料送入水解釜，加入丙酮，再用液碱中和，将中和液蒸馏，得丙酮肟。将丙酮肟和盐酸加入成盐釜中反应，生成盐酸羟胺和丙酮。丙酮回收使用；盐酸羟胺经浓缩、冷却结晶、离心分离、干燥，即得成品。原料消耗定额：亚硝酸钠（95%）1970kg/t、焦亚硫酸钠（以SO2计64%）5418kg/t、丙酮（98%）1175kg/t。2.硝基甲烷法硝基甲烷与盐酸、水作用以制得盐酸羟胺。
• 所属类别一:无机化工产品: 无机盐: Ce液化物及氯酸盐