CAS 79-19-6 MFCD00007620-Thiosemicarbazide 氨基硫脲 TAO{mole}

Thiosemicarbazide 氨基硫脲

CAS 79-19-6 MFCD00007620

化学结构图

SMILES: NNC(N)=S

化学属性

Mol. Formula	CH5N3S
Mol. Weight	91.14
Melting Point	180-183°C
TSCA	Yes
Density	1.376
Solubility	可溶
Stability	对湿度敏感
Appearance	白色结晶或白色结晶性粉末。溶于水和乙醇。
Boiling Point	208.6°C at 760 mmHg

别名和识别编码

Chemical Name	Thiosemicarbazide
CAS Number	79-19-6
Alfabeta Name	THIOSEMICARBAZIDE
MDL Number	MFCD00007620
Synonym	Thiosemicarbazide {LY} Thiosemicarbazide {} {LY} Thiosemicarbazide {} {} {LY} Thiosemicarbazide {} {} {} {LY} Thiosemicarbazide {} {} {} {} {LY} Thiosemicarbazide {} {} {} {} {} {LY} Thiosemicarbazide {} {} {} {} {} {} {LY} Thiosemicarbazide {} {} {} {} {} {} {} {LY} Thiosemicarbazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thiosemicarbazide {} {} {} {} {} {} {} {} {} {LY} Thiosemicarbazide {} {} {} {} {} {} {} {} {} {} {LY} Thiosemicarbazide {} {} {} {} {} {} {} {} {} {} {} {LY} Thiosemicarbazide {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thiosemicarbazide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thiosemicarbazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thiosemicarbazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thiosemicarbazide {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID	2723789
EC Number	201-184-7
Beilstein Registry Number	3,195
Reaxys-RN	506320
Merck Number	9361
Chemical Name Translation	氨基硫脲
Wiswesser Line Notation	ZMYZUS
LabNetwork Molecule ID	LN00173077
InChI	InChI=1S/CH5N3S/c2-1(5)4-3/h3H2,(H3,2,4,5)
Canonical SMILES	NNC(N)=S

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产品应用

铜的络合剂。测定铬的沉淀剂。检定某些金属和糖、醛、酮的试剂。毒鼠药制备。本品为有机合成中间体，用于合成抗结核药氨硫脲和磺胺药物，以及杀鼠剂。还可用作铬的定量及醛酮鉴定的分析试剂。此外，本品也用作农药中间体、橡胶助剂和合成树脂添加剂等。

安全信息

Warnings IRRITANT

GHS Symbol

WGK Germany3

Hazard statements

H300 Fatal if swallowed 吞食致命
H302 Harmful if swallowed 吞食有害

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes T+

RTECSVT4200000

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310+P330
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P273 Avoid release to the environment. 避免释放到环境中。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P405 Store locked up. 上锁保管。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P301+P310
P301+P312+P330
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P302+P352+P332+P313+P362+P364

Signal word

UN Number 3077 2811

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R52/53
R28 Very toxic if swallowed 吞咽极毒

Packing GroupII

Storage condition 2-8°C {LY} 2-8°C Poison room {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

Hazard Class6.1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1024 mg/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 67,75,1981

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2048 mg/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 67,75,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9160 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MarJV# Personal Communication from J.V. Marhold, VUOS, 539-18, Pardubice,
   Czechoslavakia, Mar. 29, 1977  Volume(issue)/page/year: 29MAR1977

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Ocular
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Blood - hemorrhage
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0539438

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 9100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,315,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16407 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   21,635,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROU

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 20 umol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   25,821,1976

其他信息

{Chem
{
硫代氨基脲价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30179024 硫代氨基脲;氨基硫脲;硫氨脲 25g 10元 2011/04/16 T0221 氨基硫脲 Thiosemicarbazide 500G 1080元 2011/04/16 T0221 氨基硫脲 Thiosemicarbazide 25G 189元
上游原料:硫脲 --> 硫氰酸铵 --> 硫酸肼
防护措施:氨基硫脲为毒物，含氨基硫脲的制剂有毒。
图谱信息:硫代氨基脲(79-19-6)红外图谱(IR2) 硫代氨基脲(79-19-6)质谱(MS) 硫代氨基脲(79-19-6)核磁图( 13 CNMR) 硫代氨基脲(79-19-6)红外图谱(IR1)
方法二:1.以硫脲与水合肼为原料进行加热反应制得。2.由水合肼与硫酸配制成硫酸肼，与硫氰酸铵反应生成硫氰酸肼，再与乙醛反应后经水解得到氨基硫脲。
可燃性危险特性:燃烧产生有毒硫氧化物和氮氧化物气体
灭火剂:干粉、泡沫、砂土
{Chemicalb
用途四:本品为有机合成中间体，用于合成抗结核药氨硫脲和磺胺药物，以及杀鼠剂。还可用作铬的定量及醛酮鉴定的分析试剂。此外，本品也用作农药中间体、橡胶助剂和合成树脂添加剂等。
毒性分级:剧毒
下游产品:(6R,7R)-7-[[(2E)-2-(2-氨基-1,3-噻唑-4-基)-2-甲氧基亚氨乙酰]氨基]-3-[(2-甲基-5,6-二氧代-1H-1,2,4-三嗪-3-基)硫甲基]-8-氧代-5-硫-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸 --> 2-氯-4-嘧啶甲酸 --> 盐酸氯苯胍 --> 川化-108 --> 2-氨基-5-羧基-1,3,4-噻二唑 --> 苯酮唑 --> 2-氨基-1,3,4-噻二唑-5-甲酸乙酯 --> 灭蚜松粉剂、可湿性粉剂、拌种剂 --> 1,2,3,4-噻三唑-5-胺 --> 3-叔丁基-5-巯基-1,2,4-三唑 --> 橡胶助剂 --> 农药中间体
用途三:氨基硫脲又名硫代氨基脲，是制备氨基甲酸酯类杀虫剂唑蚜威以及噻二唑类杀菌剂和杀鼠剂的中间体，也可用于合成抗结核药氨硫脲和磺胺药物、橡胶助剂和合成树脂添加剂等，还可用作铬的定量及醛酮鉴定的分析试剂
海关编码:29335995
Alfa Aesar:氨基硫脲,99% Thiosemicarbazide, 99%(79-19-6)
方法一:氨基硫脲是以水合肼、硫氰酸铵为原料，以乙醛为催化剂制得。反应方程式见：2H 2 NNH 2 ·H 2 O+H 2 SO 4 →(H 2 NNH 2 ) 2 ·H 2 SO 4 +2H 2 O (H 2 NNH 2 ) 2 ·H 2 SO 4 +2NH 4 SCN→2H 2 NNH 2 ·HSCN+(NH 4 ) 2 SO 4 先将一定量的水合肼放入三口瓶内，以水冷却，在搅拌下缓慢加入一定浓度的硫酸，保持温度在40℃以下，控制pH=4～5为终点即得硫酸肼。然后加入硫氰酸铵，搅拌，在30℃加入一定量乙醛(或丙酮)，然后趁热将反应物移至烧杯中，在室温下放置4h，析出结晶，经过滤、水洗、干燥而得成品，收率80%以上。另外，也可以硫脲与水合肼为原料进行加热反应制得。
F:8-9-23
用途五:铜的络合剂。测定铬的沉淀剂。检定某些金属和糖、醛、酮的试剂。毒鼠药制备。本品为有机合成中间体，用于合成抗结核药氨硫脲和磺胺药物，以及杀鼠剂。还可用作铬的定量及醛酮鉴定的分析试剂。此外，本品也用作农药中间体、橡胶助剂和合成树脂添加剂等。
用途一:用于合成抗结核药氨硫脲和磺胺药物，用作农药中间体、橡胶助剂、合成树脂添加剂以及分析试剂等
MSDS 信息:3-Thiosemicarbazide(79-19-6).msds
储运特性:库房通风低温干燥; 与食品原料分开储运
用途四:本品为有机合成中间体，用于合成抗结核药氨硫脲和磺胺药物，以及杀鼠剂。还可用作铬的定量
类别:农药