CAS 123-91-1 MFCD00006571-1,4-Dioxane 1,4-二氧六环 TAO{mole}

1,4-Dioxane 1,4-二氧六环

CAS 123-91-1 MFCD00006571

化学结构图

SMILES: C1COCCO1

化学属性

Mol. Formula	C4H8O2
Mol. Weight	88.11
Refractive index	1.4200 to 1.4240
Boiling Point	100-102
Density	1.034
Melting Point	10-12
Flash Point	12°C(lit.)
TSCA	Yes
Autoignition Point	356 °F
Vapor Density	3 (vs air)
Vapor Pressure	27 mmHg ( 20 °C)
Solubility	可溶
Stability	易吸潮
Danger-Level	甲类
pH	-:-
Redox	-

别名和识别编码

Chemical Name	1,4-Dioxane
Synonym	(1,4)dioxane 1,4-DIOXANE 1,4-Diethylene dioxide 1,4-Dioxin, tetrahydro- 1,4-二噁烷,环二氧二乙烯,环氧二乙烷,二氧己环,乙二醇二醚,二氧杂环己烷 1,4-二氧六环 C₄H₈O₂ (1,4-dioxane) DIETHYLENE OXIDE DIOX Di(ethylene oxide) Diethylendioxid Diethylene dioxide Diethylene oxide Diethylene oxide ethe Diokan Diossano-1,4 Dioxaan-1,4 Dioxanne Dioxyethylene ether NCI-C03689 p-Dioxan p-Dioxin, tetrahydro- 二氧六环二氧杂环乙烷
CAS Number	123-91-1
PubChem Substance ID	87567468
EC Number	204-661-8
Beilstein Registry Number	102551
MDL Number	MFCD00006571
Reaxys-RN	102551
Merck Number	3300
Chemical Name Translation	1,4-二氧六环
Wiswesser Line Notation	T6O DOTJ
LabNetwork Molecule ID	LN00164131
InChI	InChI=1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2

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品牌质保精细包装现货库存一流品牌服务

产品应用

溶剂，非水滴定中常用溶剂，从钾和钠中分离锂。木质素萃取剂。

安全信息

GHS Symbol

WGK Germany2

Hazard Codes 3 F,T T

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
H335 May cause respiratory irritation 可能导致呼吸道刺激
H350 May cause cancer 可能致癌
H340 May cause genetic defects 可能导致遗传性缺陷
H319 Causes serious eye irritation 严重刺激眼睛
H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSJG8225000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P241+P242+P243
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P302+P352+P332+P313+P362+P364
P303+P361+P353
P304+P340+P312
P305+P351+
P305+P351+P338
P305+P351+P338+P337+P313
P308+P311
P332+P313
P337+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P403+P233
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

Safety Statements

S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S46 If swallowed, seek medical advice immediately and show this container or label 食入时，立即求医并出示容器/标签；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐：立即求医并出示该容器或标签；
S7 Keep container tightly closed 保存在严格密闭容器中；
S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；

Risk Statements

R11 Highly flammable 非常易燃
R19 May form explosive peroxides 可能生成易爆的过氧化物质
R36/37 Irritating to eyes and respiratory system 对眼睛和呼吸系统有刺激性
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R66 Repeated exposure may cause skin dryness or cracking 反复接触可能导致皮肤干燥或皴裂

UN Number 1165

Storage condition Flammables area 易吸潮 Hygroscopic

Packing GroupII

Hazard Class3

Warnings 危化品目录(2015)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14 gm/kg/60W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 5,163,1973

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 111 ppm/7H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   30,287,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 239 gm/kg/90W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-80,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 185 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For pub

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 21,173,1939

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 16,54,1978

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 5500 ppm/1M
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Sense Organs and Special Senses (Eye) - conjunctive irritation
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   PHRPA6 Public Health Reports.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402)  V.1-    1878-  Volume(issue)/page/yea

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 46 gm/m3/2H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
   KBAMAJ Kosmicheskaya Biologiya I Aviakosmicheskaya Meditsina.  Space Biology
   and

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       :

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 20 mg/kg
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   60,287,1981

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 300 umol/L
REFERENCE :
   SinJF# Personal Communication from J.F. Sina, Merck Institute for
   Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
   Volume(issue)/page/year: 26OCT1982

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 900 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 322,142,19

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 2550 mg/kg
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., P

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Intravenous
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   49,29,1981

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 1 gm/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11,41,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 26,85,1985

Restrict -

其他信息

用途三:用作醋酸纤维素、植物油、矿物油、溶性染料等的溶剂，用于制喷漆、清漆、增塑剂、润滑剂等
急性毒性:腹注- 大鼠 LD50: 799 毫克/ 公斤; 口服-小鼠 LD50:5700 毫克/公斤
二氧六环纯化与除水方法:二氧六环能与水任意混合，常含有少量二乙醇缩醛与水，久贮的二氧六环可能含有过氧化物（鉴定和除去参阅乙醚）。二氧六环的纯化方法，在500mL二氧六环中加入8mL浓盐酸和50mL水的溶液，回流6~10h ，在回流过程中，慢慢通入氮气以除去生成的乙醛。冷却后，加入固体氢氧化钾，直到不能再溶解为止，分去水层，再用固体氢氧化钾干燥24h。然后过滤，在金属钠存在下加热回流8~12h，最后在金属钠存在下蒸馏，压入饥丝密封保存。精制过的1,4-二氧环己烷应当避免与空气接触。
1,4-二氧六环价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 10008991 1，4-二氧六环;1,4-二烷; 环二氧二乙烯; 环氧二乙烷; 二氧己环; 乙二醇二醚; 二氧杂环己烷 500ml 450元 2011/08/23 10008918 1，4-二氧六环;1,4-二烷; 环二氧二乙烯; 环氧二乙烷; 二氧己环; 乙二醇二醚; 二氧杂环己
{Chemic
毒性分级:中毒
TCI Shanghai:1,4-二氧六环(含稳定剂3,5-二叔丁基-4-羟基甲苯) 1,4-Dioxane (stabilized with BHT),>;99.0%(GC)(123-91-1)
下游产品:2,4,5-三氟苯乙酸 --> 2-苯基喹啉 --> 3-苯基吡唑 --> 左西孟旦 --> 9-氯甲基蒽 --> 聚氨酯-聚硅氧烷共聚物 --> 安心酮 --> 2-羟基-4-吡啶醛 --> 1-Boc-4-哌啶甲酸 --> 地红霉素 --> 乙嘧替氟 --> 5-溴尿嘧啶 --> 7-喹啉甲醛 --> 2-羟基-1-萘甲酸 --> 过氧化氢酶 --> Fmoc-O-叔丁基-L-酪氨酸 --> 吡西卡尼 --> Γ-L-谷氨酰-1-萘胺 --> 4-氨基-2,6-二羟基嘧啶 --> N-乙酰基乙二胺 --> 2-溴-4'-(三氟甲基)苯乙酮 --> 4-甲基-5-(2-乙酰氧乙基)噻唑 --> N-十四烷基甘氨酸钠盐 --> BOC-甘氨酸 --> Boc-O-苄基-L-酪氨酸 --> FMOC-O-叔丁基-L-丝氨酸 --> Fmoc-O-叔丁基-L-苏氨酸 --> 8-羟基喹啉-2-甲醛 --> 3-甲基吡啶-4-醛 --> 己烯雌酚 --> BOC-D-丙氨酸 --> N-叔丁氧羰基-Β-丙氨酸 --> DL-天冬酰胺一水物 --> BOC-D-苯丙氨酸 --> BOC-L-苯丙氨酸 --> N-叔丁氧羰基-O-苄基-L-苏氨酸
F:8
蒸气压:27
参考质量标准:[性　　状] 无色透明液体 [酸　　值] ≤0.01%(以CH3COOH计) [密　　度] 1.030-1.035g/ml(20℃) [凝固点] ≥11.0℃ [蒸发残渣] ≤0.01% [醛] 适合试验 [过氧化物] ≤0.005%(以H2O2计) [水　　份] ≤0.1% [含　　量] ≥99.5%
用途四:该品在医药、化妆品、香料等特殊精细化学品制造，以及科学研究中作为溶剂、反应介质、萃取剂使用。在日本，该品主要用作1,1,1-三氯乙烷的稳定剂，添加量为2.5-4%；其次，应用较多的是作为聚氨酯合成革、氨基酸合成革等的反应溶剂。该品溶解能力强，与二甲基甲酰胺相近，比四氢呋喃强。二氧六环有以下用途值得重视：（1）与三氧化硫形成络合物，可用作许多化合物合成时的硫酸化剂；（2）用于医药、农药的提取，石油产品的脱蜡等；（3）用作染料分散剂、木材着色剂的分散剂以及油溶性染料的
微有醚样气味。对光敏感。易吸收氧形成爆炸性的过氧化物。能与水形成共沸混合物(含水18.6%)。与四硝基甲烷反应呈鲜黄色。能与水及多种有机溶剂混溶。易燃。蒸气能与空气形成爆炸性混合物。爆炸极限1.97%-22.5%(体积)。低毒，半数致死量（大鼠，经口）4200mg/kg。有致癌可能性。有刺激性。商品常加微量2，6-二叔丁基对甲酚(BHT)作稳定剂。
方法一:由乙二醇（或