Diethylamine 二乙胺
CAS 109-89-7 MFCD00009032
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信息真实价格透明
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专业采购外包团队在线服务
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分类
- {SNA} Hordeum vulgare (Barley), Humulus lupulus (Hops), Phytochemicals by Plant (Food/Spice/Herb), 细胞生物学, 营养研究
- {SNA} Analytical Reagents for General Use, C-D, Puriss p.a., Puriss p.a., 分析/色谱, 分析试剂
- {uni_hamburg} no charge; 1fragment
- {SA} Chemical Synthesis, Organic Bases, Synthetic Reagents
- {Chemicalbook} 农药中间体: 杀虫剂中间体: 有机磷类杀虫剂
- {SNA
产品应用
- 检定锑、铂和锡,测定二硫化碳和镁,有机合成。
- 二乙胺为溶剂和化工原料中间体,可制取药物普鲁卡因、氯喹、尼可刹米、可拉明及磺胺等类药,也可用于生产农药、染料、橡胶硫化促进剂、选矿药剂(硫氮9号);纺织助剂、杀菌剂、缓蚀剂、阻聚剂和抗冻剂等。
相关文献及参考
- In combination with Lithium aluminum hydride, A18116, generates lithium tris(diethylamino)aluminum hydride, which is a useful selective reducing agent, for example: esters to aldehydes: J. Org. Chem., 52, 5486 (1987); amides to aldehydes: Tetrahedron Lett., 32, 6903 (1991).
- Merck:14,3111
- Short: II/27B
- Merck:14,3111 Beilstein:4,95
- Short: II/25C
- Alkali metal diethylamides, generated with n-BuLi or NaH, have been used for the cleavage of ethers: J. Organomet. Chem., 55, 41 (1973); Synthesis, 638 (1980), and of alkyl aryl sulfides, for which HBr and HI are usually poor: Synthesis, 583 (1982).
安全信息
GHS Symbol
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H311 Toxic in contact with skin 皮肤接触中毒
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H302+H332
- H332 Harmful if inhaled 吸入有害
- H312 Harmful in contact with skin 皮肤接触有害
- H302 Harmful if swallowed 吞食有害
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P303+P361+P353
- P303+P361+P353+P310+P363
- P305+P351
- P305+P351+P338
- P308+P311
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- R11 Highly flammable 非常易燃
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R35 Causes severe burns 会导致严重灼伤
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S29 Do not empty into drains 不要排入下水道;
- S3 Keep in a cool place 保存在阴凉处;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 820 uL/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 5000 mg/m3 TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 14,80,1975
TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 20 gm/m3 TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Lungs, Thorax, or Respiration - emphysema Liver - fatty liver degeneration REFERENCE : 12OVAW "Voprosy Promyshlennoi Toksikologii," Pravdin, N.S., ed., Akademiya Meditsinskikh Nauk-SSSR, Moscos, Russia, 1960 Volume(issue)/page/year: -,176,1960
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4000 ppm/4H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEHLAU Archives of Environmental Health
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 400 uL/plate REFERENCE : EJMBA2 Egyptian Journal of Microbiology. (National Information and Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt) V.7- 1972- Volume(issue)/page/year: 15,113,1980
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 200 uL/plate REFERENCE : EJMBA2 Egyptian Journal of Microbiology. (National Information and Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt) V.7- 1972- Volume(issue)/page/year: 15,113,1980
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 50 uL/plate REFERENCE : EJMBA2 Egyptian Journal of Microbiology. (National Information and Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt) V.7- 1972- Volume(issue)/page/year: 16,133,1981
其他信息
- 急性毒性:口服- 大鼠 LD50: 540 毫克/ 公斤; 口服- 小鼠 LD50: 500 毫克/ 公斤
- 下游产品:孟鲁司特 --> 4-碘代苯乙酮 --> 4,6-二甲基-3-氨基吡唑并[3,4-B]吡啶 --> 2-氨基-6-甲基-4,5,6,7-四氢-1-苯并噻吩-3-腈 --> 2-氨基-5,6-二氢-4H-环戊烯并噻吩-3-甲腈 --> 1,4,6-三甲基-3-氨基吡唑并[3,4-B]吡啶 --> 乐可安 --> N,N-二乙基氯甲酰胺 --> 肉桂酸苄酯 --> 2-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩 --> 2-氨基-3-腈基-4,5-二甲基噻吩 --> 柳酸苄酯 --> 5-氨基-3-甲基噻吩-2,4-二甲酸二甲酯 --> 3-氰基-4,6-二甲基-2-羟基吡啶 --> 1-二乙胺基甲酰基-4-甲基哌嗪 --> 红色基 ITR --> 2-(N,N-二乙基甲酰氨)苯基硼酸 --> 二乙基二硫代氨基甲酸锌 --> 酚磺乙胺 --> 2-氯-3-氰基-4,6-二甲基吡啶 --> 盐酸利多卡因 --> 1,1-二乙基胍盐酸盐 --> N,N-二乙基氰乙酰胺 --> 盐酸普鲁卡因 --> 双(二乙胺基)氯磷 --> 二乙胺盐酸盐 --> N-氰基二乙基胺 --> S-2-(4-氯苯基)-3-甲基丁酸 --> 桃红色基ITR --> 3-二乙胺基丙胺 --> 铁锚102涂层胶 --> 避蚊胺 --> N,N-二乙基烟酰胺 --> 二硫化四乙基秋兰姆 --> 二乙基二硫代氨基甲酸二乙铵盐 --> N,N-二乙基-2-氯丙酰胺 --> 六乙基亚磷酸胺
- 用途五:检定锑、铂和锡,测定二硫化碳和镁,有机合成。二乙胺为溶剂和化工原料中间体,可制取药物普鲁卡因、氯喹、尼可刹米、可拉明及磺胺等类药,也可用于生产农药、染料、橡胶硫化促进剂、选矿药剂(硫氮9号);纺织助剂、杀菌剂、缓蚀剂、阻聚剂和抗冻剂等。
- 防护措施:本品为毒、腐蚀性易燃品。其蒸气或液体均对眼睛、皮肤和呼吸道粘膜有刺激和腐蚀作用,引起搔痒、红肿,严重时,会造成损伤。大量接触会穿透组织引起深度坏死。鼠类经口LD50为540mg/kg。生产现场最高容许浓度75mg/m3。生产设备应密闭。操作人员应戴防毒口罩、胶乳手套、橡胶围裙和眼镜等防护用品。溅及皮肤时,应用清水冲洗,以2%的醋酸、柠檬酸或硼酸溶液湿敷。如眼睛溅入二乙胺,要立即张开双眼,用水进行彻底冲洗,滴入2%的普鲁卡因或含有0.1%肾上腺素的0.5%的普鲁卡因溶液,随后涂擦消过毒的凡士林或橄榄油。戴上防护眼镜,请眼科医生诊治。
- MOL 文件:109-89-7.mol
- 毒性分级:高毒
- F:10-23
- Sigma Aldrich:109-89-7(sigmaaldrich)
- 敏感性:Air Sensitive
- 蒸气压:14.14 psi ( 55 °C)
- 用途四:二乙胺为溶剂和化工原料中间体,可制取药物普鲁卡因、氯喹、尼可刹米、可拉明及磺胺等类药,也可用于生产农药、染料、橡胶硫化促进剂、选矿药剂(硫氮9号)、纺织助剂、杀菌剂、缓蚀剂、阻聚剂和抗冻剂等。需消耗二乙胺的医药产品及其二乙胺的消耗量:头孢唑啉钠0.789kg/kg、头孢拉啶0.059kg/kg、合成黄连素0.030kg/kg、磺胺嘧啶0.150kg/kg、磷酸氯喹0.340kg/kg、咳必清0.710kg/kg、灭吐灵0.960kg/kg、止血敏0.660kg/kg、盐酸普鲁卡因0.600kg/kg、盐酸利多卡因0.890kg/kg。
- TCI Shanghai:二乙胺 Diethylamine,>;99.0%(GC)(109-89-7)
- Alfa Aesar:二乙胺,99% Diethylamine, 99+%(109-89-7)
- 储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
- 有强烈氨臭,强碱性,呈碱性反应。能与水、乙醇和乙醚等有机溶剂混溶。
- 灭火剂:干粉、雾状水、二氧化碳、泡沫
- 用途一:用作医药、
- 用途二:用作分析试剂和防腐剂,也用于有机合成及染料的制造
- 爆炸物