Toluene 甲苯(易制毒)

CAS 108-88-3 MFCD00008512

化学结构图

108-88-3
SMILES: Cc1ccccc1

化学属性

Mol. FormulaC6H5CH3
Mol. Weight92.14
Density0.865 g/mL at 25 °C(lit.)
Refractive indexn/D 1.496(lit.)
Boiling Point110-111 °C(lit.)
Melting Point-93 °C(lit.)
Flash Point4°(40°F)
TSCAYes
Solubility不溶于水,可混溶于苯、醇、醚等多数有机溶剂。
Autoignition Point997 °F
Vapor Density3.2 (vs air)
Vapor Pressure22 mmHg ( 20 °C)
Stability对光线敏感
Danger-Level-
pH-:-
Redox-

别名和识别编码

Chemical NameToluene
CAS Number108-88-3
EC Number203-625-9
Beilstein Registry Number635760
MDL NumberMFCD00008512
PubChem Substance ID57648083
Merck Number14,9529
Synonym RCRA waste number U220 甲苯;甲苯溶液 Tolueno CP 25 Toluene Toluolo Toluol Methylbenzol NCI-C07272 Phenylmethane 甲苯 Methacide Antisal 1a 甲基苯,苯基甲烷 Methane, phenyl- Tol; Toluol; Methylbenzene Toluen Methylbenzene Tolueen Tolu-Sol Benzene, methyl-
Chemical Name Translation甲苯(易制毒)
Wiswesser Line Notation1R
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分类

  • {SNA} Amber Glass Bottles, PRA, Solvent Bottles, Solvent Packaging Options, Solvents
  • {SA} Analytical Reagents, Analytical/Chromatography, Spectroscopy,
  • {SNA} Alphabetical Index of Analytical Standards, Chemical Class, Method and Regulation Specific, Alpha Sort, Analytical Standards, Analytical/Chromatography, Aromatics, Chromatography, EPA, Endocrine Disruptors (Draft), Environmental Standards, Hydrocarbons, Neats,
  • {SNA} Aluminum Bottles, Amber Glass Bottles, Reagent, Solvent Bottles, Solvent Packaging Options, Solvents
  • {SNA} Anhydrous,
  • {SNA

产品应用

  • 制造染料、制香料、苯甲醛、苯甲酸及其他有机化合物,树脂、树胶和乙酸纤维素等溶剂,植物成分浸出剂。

相关文献及参考

  • Merck:14,9529
  • Merck:14,9529 Beilstein: 5,IV,766

安全信息

GHS Symbol
WGK Germany2
Hazard Codes F,Xn F;Xn
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSXS5250000
Precautionary statements
  • P301+P310
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P331 Do NOT induce vomiting.. 不要催吐。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P370+P378
  • P403+P235
Signal word Danger
UN Number 1294 UN1294
Risk Statements
  • R11 Highly flammable 非常易燃
  • R38 Irritating to skin 刺激皮肤
  • R48/20
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
Safety Statements
  • S46 If swallowed, seek medical advice immediately and show this container or label 食入时,立即求医并出示容器/标签;
  • S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐:立即求医并出示该容器或标签;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Packing GroupII
Storage condition 密封阴凉处保存。 储存温度2-8℃
Warnings 危化品目录(2015) 危险化学品
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HAEMAX Haematologica.  (Il Pensiero Scientifico Editore, Via Panama 48,
   I-00198, Rome, Italy) V.1-    1920-  Volume(issue)/page/year: 58,491,1973

TYPE OF TEST            : LC50 - Lethal concentration, 50 p

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : In

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NRTXDN Neurotoxicology.  (Intox Press, Inc., POB 34075, Little Rock, AR
   72203)  V.1-    1979-  Volume(issue)/page/year: 8,237,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NRTXDN Neurotoxicology.  (Intox Press, Inc., POB 34075, Little Rock, AR
   72203)  V.1-    1979-  Volume(issue)/page/year: 2,567,1981

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 55000 ppm/40M
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 26,69,1944

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Insect - grasshopper
DOSE/DURATION           : 20 pph/16H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 113,467,1983

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 5400 ug/m3/16W (Intermittent)
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 25(7),33,1981

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 433 ug/kg/24H
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   58,106,1985

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 9600 mg/kg/12D (Intermittent)
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 37(10),36,1972

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 pph
REFERENCE :
   JOBAAY Journal of Bacteriology.  (American Soc. for Microbiology, 1913 I
   St., NW, Washington, DC 20006)  V.1-    1916-  Volume(issue)/page/year:
   137,397,1979

TYPE OF TEST            : Sex chromosom

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1500 mg/m3/24H
SEX/DURATION            : female 1-8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 11,55,1978

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2000 ppm/6H
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Eff

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1000 mg/m3/24H
SEX/DURATION            : female 7-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   FMORAO Folia Morphologica (Prague).  (Plenum Pub. Corp. 233 Spring St., New
   York, NY 10013) V.13-    1965-  Volume(issue)/page/year: 28,286,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7280 mg/kg
SEX/DURATION            : female 6-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   PEREBL Pediatric Research.  (Williams & Wilkins Co., 428 E. Preston St.,
   Baltimore, MD 21202) V.1-    1967-  Volume(issue)/page/year: 36,811,1994

Restrict 易制毒

其他信息

  • 有苯样气味。易燃,具折光。能与醇、醚、丙酮、氯仿、二硫化碳和冰乙酸混溶,极微溶于水。易燃。蒸气能与空气形成爆炸性混合物,爆炸极限1.2%-7.0%(体积)低毒,半数致死量(大鼠,经口)5000mg/kg。高浓度气体有麻醉性。有刺激性。
  • 挥发性有机化合物(VOCs)单组分标准液
  • 挥发性有机化合物(VOCs)单组分标准液 US EPA方法:502.2,524.2,8021,8021A,8021B,624,8240B,8260B

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