CAS 50-23-7 MFCD00011654-Hydrocortisone 11Beta,17Alpha,21-三羟基孕甾-4-烯-3,20-二酮 TAO{mole}

Hydrocortisone 11Beta,17Alpha,21-三羟基孕甾-4-烯-3,20-二酮

CAS 50-23-7 MFCD00011654

化学结构图

SMILES: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO

化学属性

Mol. Formula	C21H30O5
Mol. Weight	362.46
Melting Point	211-214 °C
TSCA	Yes
Density	1.28
Stability	对光敏感
Flash Point	220°C
Appearance	D +157.5°(二噁烷)、+176°(氯仿)、+162°-+169°(乙醇)；乙醇溶液在242nm波长处有最大吸收。本品不溶于水，难溶于乙醚，微溶于氯仿，溶于丙酮、乙醇。可溶于浓硫酸液并呈绿色荧光。LD (大鼠，腹腔)150mg/kg。 25 powder 白色或类白色结晶性粉末，无臭，味苦。遇光变质。Mp214-220℃(分解)；比旋光度[α] 50
Solubility	H2O: 100 mg/mL
Boiling Point	414.06 °C at 760 mmHg

别名和识别编码

Chemical Name	Hydrocortisone
MDL Number	MFCD00011654
CAS Number	50-23-7
Synonym	Hydrocortisone {LY} Hydrocortisone {} {LY} Hydrocortisone {} {} {LY} Hydrocortisone {} {} {} {LY} Hydrocortisone {} {} {} {} {LY} Hydrocortisone {} {} {} {} {} {LY} Hydrocortisone {} {} {} {} {} {} {LY} Hydrocortisone {} {} {} {} {} {} {} {LY} Hydrocortisone {} {} {} {} {} {} {} {} {LY} Hydrocortisone {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone {} {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrocortisone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number	200-020-1
Beilstein Registry Number	1354819
PubChem Substance ID	5754
Merck Number	4787
Reaxys-RN	2226798
Chemical Name Translation	11Beta,17Alpha,21-三羟基孕甾-4-烯-3,20-二酮
InChIKey	JYGXADMDTFJGBT-VWUMJDOOSA-N
Wiswesser Line Notation	L E5 B666 OV MUTJ A1 CQ E1 FV1Q FQ
LabNetwork Molecule ID	LN00830918
InChI	InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
Canonical SMILES	C[C@@]1([C@@]2(O)C(CO)=O)[C@](CC2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])[C@@H](O)C1

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产品应用

肾上腺皮质（the adrenal cortex）分泌的主要的糖皮质激素，它的消炎能力是皮质酮（corticosterone）的三倍。

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H303 May be harmfully swallowed 吞食可能有害
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Gloves

RTECSGM8925000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P305+P351+P338
P308+P313
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
R62 Possible risk of impaired fertility 有削弱生殖能力的危险
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Hazard Codes Xn

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Biochemical - Metabolism (Intermediary) - effect on inflammation or
   mediation of inflammation
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 21,377,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KHFZAN Khimiko-Farmatsevticheskii Zhurnal.  Chemical Pharmaceutical Journal.
    For English translation, see PCJOAU.  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR)  V.1-    1967-  Volume(issue)/page/year: 24(3),26,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 449 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   8,250,1966

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 100 nmol/L
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 36,1782,1986

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bird - chicken Embryo
DOSE/DURATION           : 450 pmol/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 257,804,1975

TYPE OF TEST            : Unscheduled DN

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
   Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.41-    1956-  Volume(issue)/page/year: 81,90,1976

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - guinea pig Lung
DOSE/DURATION           : 1 mg/L
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 171,109,1982

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 370,49,1996

TYPE OF TEST            : Unscheduled DNA synthesis
TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 500 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   3,313,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   SJDBA9 Soviet Journal Developmental Biology (English Translation).
   Translation of Ontogenez. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.1-    1970-  Volume(issue)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 210 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 24,284,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 10 mg/kg
SEX/DURATION            : female 11-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Ab

其他信息

方法二:4-孕甾烯-17a,21-二醇-3,20-二酮-21-醋酸酯（醋酸化合物“S”）用梨头霉（Absidia Orchidis 3.
Acros Organics:氢化可的松 Hydrocortisone, 98%(50-23-7)
方法一:醋酸可的松经氨基脲缩合、硼氢化钾还原、亚硝酸钠和盐酸处理制
比旋光度:166 ° (c=1, C2H5OH 25 °C)
图谱信息:氢化可的松(50-23-7)红外图谱(IR2) 氢化可的松(50-23-7)质谱(MS) 氢化可的松(50-23-7)Raman光谱氢化可的松(50-23-7)红外图谱(IR1)
上游原料:硼氢化钾 --> 醋酸异丙酯 --> 氨基脲 --> 醋酸可的松 --> 皂素
用途一:生化研究，肾上腺皮质激素类药物。
参考质量标准:含量96%-104%，mp212-220℃，比旋光度[α] 20 D +161°-+169°，吸光系数(A)428-450；检测干燥失重、灼烧残渣等杂质含量。
MOL 文件:50-23-7.mol
Decomposition:220 °C
下游产品:11Β,17Α-二羟基-1,4-孕二烯-3,20-二酮17-丙酸酯 --> 21-乙酰氧基-6Α,9Α-二氟-11Β,16Α,17Α,三羟基孕甾-1,4-二烯-3,20-二酮 --> 21-乙酰氧基-9Α-氟-11Β,16Α,17Α-三羟基孕甾-1,4-二烯-3,20-二酮 --> 泼尼松 --> 21-乙酰氧基-9-氟-11-羟基孕甾-1,4,16-三烯-3,20-酮 --> 9Α-氟孕甾-1,4-二烯-11Β,17Α,21-三醇-3,20-二酮-17,21-二醋酸酯 --> 孕甾-3,5,9(11)-三烯-3Β,17Α,21-三醇-20-酮-3,17,21-三醋酸酯 --> 泼尼松龙 --> 孕甾-4,9(11)-二烯-17α,21-二醇-3,20-二酮21-醋酸酯 --> 6Α,9Α-二氟孕甾-4-烯-11Β,17Α,21-三醇-3,20-二酮-17,21-二醋酸酯 --> 醋酸氢化可的松 --> 21-乙酰氧基-9Β,11Β-环氧-17Α-羟基孕甾-4-烯-3,20-二酮 --> 孕甾-4,9(11)-二烯-17Α,21-二醇-3,20-二酮-17,21-二醋酸酯 --> 9Β,11Β-环氧-6Α-氟孕甾-4-烯-17Α,21-二醇-3,20-二酮-17,21-二醋酸酯 --> 9Β,11Β-环氧孕甾-4-烯-17Α,21-二醇-3,20-二酮-17,21-二醋酸酯 --> 11Β,17Α,21-三羟基孕甾-4-烯-3,20-二酮-17-丁酸酯-21-丙酸酯 --> 21-乙酰氧基-9Α-溴-11Β,17Α-二羟基孕甾-4-烯-3,20-二酮 --> 9Α-溴孕甾-4-烯-11Β,17Α,21-三醇-3,20-二酮-17,21-二醋酸酯 --> 6Β-氟孕甾-4,9(11)-二烯-17Α,21-二醇-3,20-二酮-17,21-二醋酸酯
用途三:肾上腺皮质（the adrenal cortex）分泌的主要的糖皮质激素，它的消炎能力是皮质酮（corticosterone）的三倍。
Alfa Aesar:氢化可的松,98% Hydrocortisone, 98%(50-23-7)
用途二:糖皮质激素具有抗炎、抗过敏、抗毒素、抗休克四大作用。
味苦。25℃时的溶解度（mg/ml):水0.28，乙醇15，甲醇6.2，丙酮9.3，氯仿1.6，丙二醇12.7和乙醚0.35。溶于浓硫酸呈强烈的绿色荧光。最大吸收波长242nm(E1%1cm445)。
Sigma Aldrich:50-23-7(sigmaaldrich)
氢化可的松价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 66003632 氢化可的松;氢化皮质酮;17-羟基皮质(甾)酮;可的索 5g 49.1元 2011/04/16 H0533 氢化可的松 Hydrocortisone 1G 150元 2011/04/16 H0533 氢化可的松 Hydrocortisone 25G 1350元