13-cis-Retinoic acid 13-顺式视黄酸
CAS 4759-48-2 MFCD00079542
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分类
- {SNA} Analytical Standards,
- {SNA} Bioactive Small Molecule Alphabetical Index, Gene Regulation, Gene Regulation and Expression, PPAR and RXR Regulators, R, Vitamin A, Vitamins, 抗肿瘤药物, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 营养研究
- {SNA} Additional Standards, Analytical Standards, Chromatography, Pharmaceutical Secondary Standards,
- {SNA} Analytical Standards, EP Standards, EP Standards I - K, Pharmacopeia Metrological Institutes Standards,
- {SNA} Bioactive Small Molecule Alphabetical Index, Gene Regulation, Gene Regulation and Expression, PPAR and RXR Regulators, R,
相关文献及参考
- [2]. Norris, D.A., et al., Isotretinoin produces significant inhibition of monocyte and neutrophil chemotaxis in vivo in patients with cystic acne. J Invest Dermatol, 1987. 89(1): p. 38-43.
- [3]. Rademaker, M., J.M. Wishart, and N.M. Birchall, Isotretinoin 5 mg daily for low-grade adult acne vulgaris - a placebo-controlled, randomized double-blind study. J Eur Acad Dermatol Venereol, 2013.
- [4]. Dicken, C.H., Isotretinoin treatment of pityriasis rubra pilaris. J Am Acad Dermatol, 1987. 16(2 Pt 1): p. 297-301.
- [1]. Thielitz, A. and H. Gollnick, [Isotretinoin. How should it be used?]. Hautarzt, 2013. 64(4): p. 263-8.
- [1]. Thielitz, A. and H. Gollnick, [Isotretinoin. How should it be used?]. Hautarzt, 2013. 64(4): p. 263-8.
- [2]. Norris, D.A., et al., Isotretinoin produces significant inhibition of monocyte and neutrophil chemotaxis in vivo in patients with cystic acne. J Invest Dermatol, 1987. 89(1): p. 38-43.
- [3]. Rademaker, M.,
安全信息
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P302+P350
- P302+P352
- P302+P352+P332+P313+P362+P364
- P304+P340
- P305+P351+P338
- P305+P351+P338+P337+P313
- P308+P313
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
- P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
- S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3389 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 51ZKAN "The Retinoids, Vol.2," Sporn, M.B., et al., eds., New York, Academic Press, Inc., 1984 Volume(issue)/page/year: 2,287,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 24 mg/kg/4W-I TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes REFERENCE : GASTAB Gastroenterology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1943- Volume(issue)/page/year: 93,606,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979- Volume(issue)/page/year: 6,652,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 360 mg/kg/26W-I TOXIC EFFECTS : Skin and Appendages - sweating REFERENCE : CUTIBC CUTIS; Cutaneous Medicine for the Practitioner. (Technical Pub., 875 Third Ave., New York, NY NY 10022) 1965- Volume(issue)/page/year: 38,275,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1960 mg/kg TOXIC EFFECTS : Details of toxic effects
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Human Embryo DOSE/DURATION : 25 umol/L REFERENCE : TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 11,297,1991
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 50 umol/L REFERENCE : BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 29A,333,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 100 mg/kg SEX/DURATION : female 10-11 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : IJEPEI International Journal of Experimental Pathology. (Blackwell Scientific Publications Ltd., POB 88, Oxford, OX2 0NE, United kingdom) V.71- 1990- Volume(issue)/page/year: 73,551,1992
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE : 2400 ug/kg SEX/DURATION : female 22-24 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : AJOTBN American Journal of Otology. (J.B. Lippincott Co., 227E. Washington Square, Philadelphia, PA 19106) V.1- 1979- Volume(issue)/page/year: 15,400,1994
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE : 50 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume
其他信息
- 维 A 酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 R0064 视黄酸 Retinoic Acid 1G 1520元 2014/06/02 R0064 视黄酸 Retinoic Acid 5G 4700元 2010/06/21 207340010 维 A 酸 all-trans-Retinoic acid 97% 1 GR 1739元
- color:yellow
- 用途一:用于异常型痤疮、鱼鳞病和异常型银屑病
- 用途二:为维生素A类药物,有强而快抑制皮肤腺细胞的增生和分化过程的功能,对严重节状囊性痤疮有高效。本品肠胃吸收较好,而局部用药无效。用于其它药物治疗无效的严重痤疮、囊肿性痤疮、聚会性痤疮,对酒渣鼻、鱼鳞病、毛囊角化症及毛发红糠疹等皮肤疾患也有一定的效果。
- 用途三:维生素A酸(ATRA) 是一种维生素A酸受体(RAR)和Retinoid X 受体(RXR)的配体,结合上RAR 和 RXR作为转导因子,调控正常细胞和肿瘤细胞的生长和分化。细胞色素P450 (CYPs) 催化ATRA的羟基化;维生素A酸引导胚胎干细胞(embryonic stem cells) 演变成神经元。
- 方法一:β-紫罗兰酮和乙基氯化镁反应后,再和三苯膦反应形成三苯基镌盐,然后和环戊烯酮衍生物反应,生成异维A酸及其8Z异构体。 其8Z异构体分离后,经硝酸钯作用异构化为异维A酸。
- Acros Organics:13-顺式视黄酸(异维A酸) 13-cis-Retinoic acid, 99%(4759-48-2)
- F:7-8-16-23
- 用途二:用于异常型痤疮、鱼磷病和异常型银屑病。
- 异维 A 酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 418975000 异维 A 酸 13-cis-Retinoic acid 99% 500 MG 2585元
- MSDS 信息:3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid(302-79-4).msds
- Alfa Aesar:视黄酸,98% Retinoic acid, 98%(302-79-4)
- Acros Organics:全反式维甲酸/视黄酸 all-trans-Retinoic acid, 97%(302-79-4)
- 上游原料:三苯基膦 --> 紫罗兰酮 --> 乙基氯化镁 --> 环戊烯酮 --> 硝酸钯
- Sigma Aldrich:302-79-4(sigmaaldrich)
- MSDS 信息:13-cis-Retinoic acid(4759-48-2).msds
- 用途三:用于严重痤疮等。
- MOL 文件:4759-48-2.mol
- MOL 文件:302-79-4.mol
- Sigma Aldrich:4759-48-2(sigmaaldrich)
- TCI Shanghai:视黄酸 Retinoic Acid,>;98.0%(T)(302-79-4)
- 图谱信息:维 A 酸(302-79-4)红外图谱(IR1)
- 维 A 酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 R0064 视黄酸 Retinoic Acid 1G 1250元 2011/04/16 R0064 视黄酸 Retinoic Acid 5G 3880元 2010/06/21 207340010 维 A 酸 all-trans-Retinoic acid 97% 1 GR 1739元
- 用途一:用于治疗严重痤疮等症