4-Chloromethylpyridine Hydrochloride 4-氯甲基吡啶盐酸盐
CAS 1822-51-1 MFCD00012826
化学结构图
SMILES: Cl.ClCC1CCNCC1
化学属性
| Mol. Formula | C6H7Cl2N |
|---|---|
| Mol. Weight | 164 |
| Melting Point | 166-173 |
| Density | 1.422 |
| TSCA | No |
| Solubility | 750 G/L (20 ºC) |
| Appearance | 白色粉末状固体或淡黄色晶体，熔点 160-163℃ ，水溶性 750g/L (20 ℃) |
别名和识别编码
| Chemical Name | 4-Chloromethylpyridine Hydrochloride |
|---|---|
| CAS Number | 1822-51-1 |
| Alfabeta Name | CHLOROMETHYLPYRIDINEHYDROCHLORIDE 4()- |
| MDL Number | MFCD00012826 |
| EC Number | 217-350-7 |
| Beilstein Registry Number | 3689154 |
| Synonym | 4-(氯甲基)吡啶 盐酸盐 4-(氯甲基)吡啶盐酸盐 4-Picolyl chloride hydrochloride |
| PubChem Substance ID | 87565871 |
| Reaxys-RN | 3689154 |
| Chemical Name Translation | 4-氯甲基吡啶盐酸盐 |
| InChIKey | ZDHKVKPZQKYREU-UHFFFAOYSA-N |
| LabNetwork Molecule ID | LN00118411 |
| InChI | InChI=1S/C6H6ClN.ClH/c7-5-6-1-3-8-4-2-6;/h1-4H,5H2;1H |
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分类
- {SNA} Building Blocks, C6, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines
- {SNA} Building Blocks, C6, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyridines
相关文献及参考
- As its free base, has been used for the protection of OH groups as 4-picolyl derivatives, relatively stable to acid (HF, TFA) but selectively cleaved by electrolytic reduction: J. Chem. Soc., Chem. Commun., 1123 (1972); Acta Chem. Scand. B, B37, 475 (1983); J. Chem. Res. (Synop.), 22 (1977). For use in the protection of the hydroxyl-substituted amino acids serine and threonine as their 4-picolyl ethers, see: J. Org. Chem., 53, 5386 (1988). In this case the group was cleaved by hydrogenolysis in AcOH. See also Appendix 6.
- Beilstein: 20,IV,2752
- Reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar 'handle' which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis: J. Chem. Soc. (C), 1911 (1969); 46, 50 (1971). For use in conjunction with Amberlyst®15 resin in peptide synthesis, see: J. Chem. Soc., Chem. Commun., 1057 (1971). For an alternative means of introduction, see 4-Pyridinemethanol, A14698.
安全信息
GHS Symbol
- S24 Avoid contact with skin 避免皮肤接触；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
- R22 Harmful if swallowed 吞咽有害
- R34 Causes burns 会导致灼伤
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R4 Forms very sensitive explosive metallic compounds 生成非常敏感的易爆炸金属化合物
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- P234 Keep only in original container. 只保留在原来的容器中。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331
- P301+P330+P331+P310
- P303+P361+P353+P310+P363
- P304+P340
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
- P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
- P405 Store locked up. 上锁保管。
- P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H290 May be corrosive to metals 可能腐蚀金属。
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
其他信息
- 下游产品:N-甲基-N-(3-甲基吡啶)胺 --> N-甲基-N-(4-吡啶甲基)胺
- Alfa Aesar:4-氯甲基吡啶.盐酸盐,98% 4-(Chloromethyl)pyridine hydrochloride, 98%(1822-51-1)
- TCI Shanghai:4-(氯甲基)吡啶盐酸盐 4-(Chloromethyl)pyridine Hydrochloride,>;97.0%(T)(1822-51-1)
- Sigma Aldrich:1822-51-1(sigmaaldrich)
- F:3-10
- 存储注意事项:湿度敏感
- 检测方法:T,NMR
- Acros Organics:4-（氯甲基）吡啶盐酸盐 4-Picolyl chloride hydrochloride, 97%(1822-51-1)
- MOL 文件:1822-51-1.mol
- 4-氯甲基吡啶盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0805 4-(氯甲基)吡啶盐酸盐 4-(Chloromethyl)pyridine Hydrochloride 25G 1040元 2014/06/02 C0805 4-(氯甲基)吡啶盐酸盐 4-(Chloromethyl)pyridine Hydrochloride 250G 5750元 2010/06/21 131201000 4-氯甲基吡啶盐酸盐 4-Picolyl chloride hydrochloride 97% 100 GR 3110元
- Hazard Note:Corrosive
- 敏感性:Hygroscopic
- 海关编码:29333999
- MSDS 信息:4-Picolyl chloride hydrochloride(1822-51-1).msds
- 图谱信息:4-氯甲基吡啶盐酸盐(1822-51-1)红外图谱(IR1) 4-氯甲基吡啶盐酸盐(1822-51-1)核磁图( 1 HNMR) 4-氯甲基吡啶盐酸盐(1822-51-1)质谱(MS) 4-氯甲基吡啶盐酸盐(1822-51-1)核磁图( 13 CNMR) 4-氯甲基吡啶盐酸盐(1822-51-1)红外图谱(IR2)
- 水溶性:750 g/L (20℃)。
