CAS 109-73-9 MFCD00011690-Butylamine 正丁胺 TAO{mole}

Butylamine 正丁胺

CAS 109-73-9 MFCD00011690

化学结构图

SMILES: CCCCN

化学属性

Mol. Formula	C4H11N
Mol. Weight	73
Density	0.74
Refractive index	1.4000 to 1.4040
Autoignition Point	594 °F
Vapor Density	2.5 (vs air)
Boiling Point	78
Vapor Pressure	68 mmHg ( 20 °C)
Melting Point	-49
Flash Point	-4°C(lit.)
TSCA	Yes
Solubility	与水混溶，可混溶于醇、乙醚。
Stability	对湿度敏感

别名和识别编码

Chemical Name	Butylamine
CAS Number	109-73-9
EC Number	203-699-2
Beilstein Registry Number	605269
MDL Number	MFCD00011690
Synonym	1-AMINOBUTANE 1-Aminobutane, n-Butylamine 1-BUTANAMINE 1-Butanamine 1-Butanaminen-butilamina 1-amino-1,1-dimethylethane 1-butylamine 1-丁胺 1-氨基丁烷 1-氨基丁烷正丁胺 1-胺丁烷 2-Amino-2-methylpropan BA BUTYLAMINE, N Butanamine Butyl amine Butylamin FEMA 3130 MNBA Mono-n-butylamine Monobutilamina Monobutylamine N-BUTYLAMINE Norvalamine RARECHEM AL BW 0075 n-Butilamina n-Butylamine 一正丁基胺丁胺正丁氨正丁胺正丁胺,一正丁基胺,丁胺,1-氨基丁烷正丁胺; 一正丁基胺; 丁胺; 1-氨基丁烷
PubChem Substance ID	8007
Merck Number	1543
Reaxys-RN	605269
Chemical Name Translation	正丁胺
InChIKey	HQABUPZFAYXKJW-UHFFFAOYSA-N
Wiswesser Line Notation	Z4
LabNetwork Molecule ID	LN00196413
InChI	InChI=1S/C4H11N/c1-2-3-4-5/h2-5H2,1H3

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产品应用

检验氰化物及某些铂金属。工业上用于生产医药、农药、染料、矿物浮选剂、乳化剂以及精细化学品的中间体等。

安全信息

Signal word Danger

GHS Symbol

WGK Germany1

Safety Statements

S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S29 Do not empty into drains 不要排入下水道；
S3 Keep in a cool place 保存在阴凉处；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R11 Highly flammable 非常易燃
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R35 Causes severe burns 会导致严重灼伤
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P233 Keep container tightly closed. ?保持容器密闭。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P241+P242+P243
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P330+P331+P310
P303+P361+P353
P304+P340
P304+P340+P310
P305+P351+P338
P305+P351+P338+P310
P308+P311
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P370+P378
P403+P233
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H332 Harmful if inhaled 吸入有害
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H312 Harmful in contact with skin 皮肤接触有害
H302 Harmful if swallowed 吞食有害
H290 May be corrosive to metals 可能腐蚀金属。
H311+H331

Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSEO2975000

Packing GroupII

UN Number 1125 UN1125

Storage condition 密封保存。充氩保存 2-8°C Air Sensitive

Hazard Codes 3 F,C

Hazard Class3/8

Warnings 危化品目录(2015)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Skin and Appendages - tumors
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   2,168,1959

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,28,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 850 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 7/19/1965

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 366 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   63,150,1982

TYPE OF TEST            : LD50

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 110 mg/kg
REFERENCE :
   ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie.  (Berlin,
   Fed. Rep. Ger.)  V.76-92, 1971-78.  For publisher information, see JCROD7.
   Volume(issue)/page/year: 86,47,1976

Restrict 危险品

其他信息

图谱信息:正丁胺(109-73
用途五:检验氰化物及某些铂金属。工业上用于生产医药、农药、染料、矿
正丁胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80024027 正丁胺;1-丁胺;1-氨基丁烷 250ml 18.4元 2011/08/23 xp400216 正丁胺;1-丁胺;1-氨基丁烷 5ml 30元 2011/04/16 B0707 正丁胺 Butylamine 25ML 155元
用途四:医药中间体，用于抗糖尿病药物的生产；农药中间体，用于氨基甲酸酯类除草剂、杀虫剂的生产；助剂中间体，用于制取裂化汽油的防胶剂、添加剂、汽油抗氧剂、橡胶阻聚剂、硅氧烷弹性体硫化剂、肥皂乳化剂；用正丁胺中和载色剂的酸度可控制醇酸和尿素磁漆的粘度；正丁胺的脂肪酸皂是有色金属浮选剂；正丁胺也是彩色相片的显影剂。美国大陆石油公司用正丁胺作脱蜡的选择性溶剂及原油破乳的表面张力抑制剂。
爆炸物危险特性:与空气混合可爆
FEMA:3130
职业标准:TWA 15 毫克/ 立方米
防护措施:本品有毒，具强碱性和腐蚀性，溶液或其蒸气强烈刺激人眼、皮肤和粘膜。吸入大量蒸气会引起头痛、恶心，严重者引起肺水肿。皮肤接触后应用大量水冲洗，溅入眼中，用流水至少冲洗15分钟，吸入中毒者应立即移到新鲜空气处，并请医生治疗。大鼠经口LD50为500mg/kg
海关编码:29211980
F:34
方法一:其制备方法是将丁醇、氨和氢气在170～200℃通过载体为白土的Cu-Ni催化剂，得到三种胺即正丁胺、二正丁胺和三正丁胺的混合物，将产物进行分馏而得到正丁胺、二正丁胺和三正丁胺的产品。反应方程式：C 4 H 9 OH+NH 3 [H 2 ]→C 4 H 9 NH 2 [C 4 H 9 OH]→(C 4 H 9 ) 2 NH[C 4 H 9 OH]→(C 4 H 9 ) 3 N 或用丁醇为原料，经与氯化氢反应生成氯丁烷，将含氨的乙醇、氨水和氯丁烷压入高压釜搅拌升温至85～95℃，压力为539～637kPa，保持6h，冷却，反应完毕，将反应液加热回收氨气，然后加入盐酸至pH＝3～4，再回收乙醇，于此粗液中加入碱液至pH＝11～12，分出上层液，经蒸馏收集95℃以下馏分为正丁胺产品。反应方程式：C 4 H 9 OH+HCl→C 4 H 9 Cl+H 2 O C 4 H 9 Cl+NH 3 [C 2 H 5 OH]→CH 3 (CH 2 ) 3
敏感性:Air Sensit
蒸气密度:2.5 (vs air)
急性毒性:口服- 大鼠 LD50: 366 毫克/ 公斤; 口服- 小鼠 LD50: 430 毫克/ 公斤
Sigma Aldrich:109-73-9(sigmaaldrich)
TCI Shanghai:正丁胺 Butylamine,>;99.0%(GC)(109-73-9)
类别:易燃液体
Acros Organics:正丁胺 n-Butylamine, 99.8%(109-73-9)
{C
刺激数据:眼睛- 兔子 250 微克/ 24小时重度; 皮肤-兔 500 毫克重度
上游原料:氢氧化钠 --> 氢氧化铵 --> 氨 --> 正丁醇 --> Α-球蛋白 --> 酸性氧化铝 --> 4-氯苯甲醛 --> 高岭土 --> 二正丁胺 --> 1-氯丁烷 --> 乙醇95% --> 三氧化钼 --> 三正丁胺
下游产品:苄嘧磺隆 --> 氯磺隆 --> 二正丁胺 --> 异氰酸正丁酯 --> 姜黄素 --> 三正丁胺 --> 紫外光氧化降解含FEDBC光敏剂的低密度聚乙烯薄膜 --> 辛伐他汀 --> 卡别多巴 --> 2-氟苯基丙酮 --> 邻甲氧基苯丙酮 --> 丁吡卡因 --> 叔丁基异氰酸酯 --> 溶剂蓝 35 --> 透明蓝
Alfa Aesar:1-丁胺,99% 1-Butylamine, 99%(109-73-9)