CAS 999-97-3 MFCD00008259-Hexamethyldisilazane 六甲基二硅氮烷 TAO{mole}

Hexamethyldisilazane 六甲基二硅氮烷

CAS 999-97-3 MFCD00008259

化学结构图

SMILES: C[Si](C)(C)N[Si](C)(C)C

化学属性

Mol. Formula	C6H19NSi2
Mol. Weight	161.39
Refractive index	1.4060 to 1.4100
Boiling Point	125
Density	0.774
Flash Point	8°C(lit.)
TSCA	Yes
Melting Point	-78
Solubility	起反应
Stability	易吸潮
pH	:A

别名和识别编码

Chemical Name	Bis(trimethylsilyl)amine
Synonym	(dimethyl-trimethylsilylamino-silyl)methane 1,1,1,3,3,3-Hexamithyl disilazane 1,1,1-trimethyl-n-(trimethylsilyl)-silanamin 1,1,1-三甲基-N-(三甲基甲硅烷基)硅烷胺 BSTFA Bis(trimethylsilyl)amine Bis-(trimethylsilyl)-amin Dow Corning® 产品 Z-6079 HMDS HEXAMETHYLDISILYLAMINE Hexamethyldisilazane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number	999-97-3
PubChem Substance ID	13838
EC Number	213-668-5
Beilstein Registry Number	635752
MDL Number	MFCD00008259
Reaxys-RN	635752
Merck Number	4689
Chemical Name Translation	六甲基二硅氮烷
Wiswesser Line Notation	1-SI-1&1&M-SI-1&1&1
LabNetwork Molecule ID	LN00195588
InChI	InChI=1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3

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产品应用

碱性硅烷化保护剂，无机填料处理剂

安全信息

GHS Symbol

WGK Germany2

Hazard statements

H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H302 Harmful if swallowed 吞食有害
H302+H332
H311 Toxic in contact with skin 皮肤接触中毒
H312 Harmful in contact with skin 皮肤接触有害
H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H315 Causes skin irritation 会刺激皮肤
H318 Causes serious eye damage 严重伤害眼睛
H319 Causes serious eye irritation 严重刺激眼睛
H332 Harmful if inhaled 吸入有害
H335 May cause respiratory irritation 可能导致呼吸道刺激
H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。

Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Hazard Codes 3 F,C

RTECSJM9230000

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P233 Keep container tightly closed. ?保持容器密闭。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
P241+P242+P243
P242 Use only non-sparking tools. 只能使用无火花工具。
P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312
P301+P317
P301+P330+P331
P301+P330+P331+P310
P302+P352
P302+P361+P354
P303+P361+P353
P303+P361+P353+P310+P363
P304+P312
P304+P340
P304+P340+P310
P305+P351+P338
P305+P351+P338+P310
P305+P354+P338
P307+P311
P308+P311
P308+P316
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P316
P317
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P317
P337+P313
P337+P317
P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
P361+P364
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P370+P378
P403+P233
P403+P235
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

UN Number 3286

Risk Statements

R11 Highly flammable 非常易燃
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R34 Causes burns 会导致灼伤
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R52/53

Safety Statements

S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S20 When using do not eat or drink 使用时，不得进食，饮水；
S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S33 Take precautionary measures against static discharges 对静电采取预防措施；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；

Storage condition +20°C 2-8°C 20 Moisture Sensitive 密封保存易潮解,密封保存

Packing GroupII

Hazard Class3/6.1, 8

Warnings 危化品目录(2015)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg/I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   54,495,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle weakness
   Skin and Appendages - hair
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0537734

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 850 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Cardiac - pulse rate
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 30(5),52,1986

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Immunological Including Allergic - decreased immune response
REFERENCE :
   StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine,
   School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975 
   Volume(issue)/page/year: 27MAY1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1 mL/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle weakness
   Skin and Appendages - hair
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   F

Restrict 危险品

其他信息

外观性质:无色、透明、易流动液体。
上游原料:乙醚 --> 氯化铵 --> 4-氯苯甲醛 --> 三甲基氯硅烷
存储注意事项:氮气保护;湿度敏感
六甲基二硅氮烷价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 A44019101 六甲基二硅氮烷 100ml 398元 2011/08/23 80068416 六甲基二硅胺烷 100ml 92.4元 2011/08/23 80068426 六甲基二硅胺烷 100ml 77.1元
TCI Shanghai:1,1,1,3,3,3-六甲基二硅氮烷 1,1,1,3,3,3-Hexamethyldisilazane,>;96.0%(GC)(999-97-3)
灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
可燃性危险特性:遇明火、高温、氧化剂易燃; 遇水分解有毒硅化物气体; 燃烧产生有毒氮氧化物烟雾
Hazard Note:Flammable
MOL 文件:999-97-3.mol
图谱信息:六甲基二硅氮烷(999-97-3)红外图谱(IR1) 六甲基二硅氮烷(999-97-3)核磁图( 13 CNMR) 六甲基二硅氮烷(999-97-3)核磁图( 1 HNMR) 六甲基二硅氮烷(999-97-3)质谱(MS)
毒性分级:中毒
类别:易燃液体
用途三:用于生产橡胶、药物。该品是消减气相色谱载体表面吸附活的减尾剂。
MSDS 信息:六甲基二硅烷胺(999-97-3).msds
TSCA:Yes
Alfa Aesar:六甲基二硅杂氮烷,Electronicgrade,99+% Hexamethyldisilazane, Electronic grade, 99+%(999-97-3)
急性毒性:口服- 大鼠 LD50: 850 毫克/ 公斤; 口服- 小鼠 LDL0: 850 毫克/ 公斤
下游产品:杂氮双环磷酸酯 --> N-乙基双氧哌嗪酰氨苯乙酸 --> 氧哌嗪酸 --> 3-甲氧基苯甲脒盐酸盐 --> 双(三甲基硅基)氨基钠 --> 6-氯-1H-吡咯并[2,3-B]吡啶 --> 双三甲基硅基胺基锂 --> 6-溴-1H-吡咯并[2,3-B]吡啶 --> 替加氟 --> 5-氟-2,4-双(三甲硅氧)嘧啶
方法一:将109g（1.0mol）三甲基氯硅烷溶于500ml无水乙醚，通入氨气，立即出现白色沉淀。加热至回流，慢慢通氨维持6h，使氯化铵沉降、过滤，取乙醚溶液先蒸出乙醚，再蒸出六甲基二硅氨烷，得52.5g，收率65%。
Acros Organics:六甲基二硅氮烷 1,1,1,3,3,3-Hexamethyldisilazane, 98%(999-97-3)
用途二:为阿米卡星药用中间体，是羟基及氨基保护剂
F:21
用途四:碱性硅烷化保护剂，无机填料处理剂
用途一:特种有机合成。阿米卡星、盘尼西林、头孢霉素、氟尿嘧啶及各种青霉素衍生物等合成过程中的甲硅烷基化。硅藻土、白炭黑、钛等粉末的表面处理。半导体工业中光致刻蚀剂的粘结助剂。
储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
Sigma Aldrich:999-97-3(sigmaaldrich)
与空气接触会迅速分解为三甲基硅醇和六甲基二硅醚，溶于多数有机溶剂。
敏感性:Moisture Sensitive