Maleic Anhydride 马来酸酐

CAS 108-31-6 MFCD00005518

化学结构图

108-31-6
SMILES: O=C1C=CC(=O)O1

化学属性

Mol. FormulaC4H2O3
Mol. Weight98.06
Autoignition Point870 °F
Vapor Density3.4 (vs air)
Boiling Point-
Vapor Pressure0.16 mmHg ( 20 °C)
Melting Point52 - 55°C
Flash Point103.33°C
Density1.48
Solubility溶于水、丙酮、苯、氯仿等多数有机溶剂。
TSCAYes
Stability对湿度敏感
Appearance powder

别名和识别编码

Chemical NameMaleic Anhydride
CAS Number108-31-6
Synonym Maleic anhydride {LY} Maleic anhydride {} {LY} Maleic anhydride {} {} {LY} Maleic anhydride {} {} {} {LY} Maleic anhydride {} {} {} {} {LY} Maleic anhydride {} {} {} {} {} {LY} Maleic anhydride {} {} {} {} {} {} {LY} Maleic anhydride {} {} {} {} {} {} {} {LY} Maleic anhydride {} {} {} {} {} {} {} {} {LY} Maleic anhydride {} {} {} {} {} {} {} {} {} {LY} Maleic anhydride {} {} {} {} {} {} {} {} {} {} {LY} Maleic anhydride {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic anhydride {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00005518
Beilstein Registry Number106909
PubChem Substance ID7923
EC Number203-571-6
Merck Number5704
Reaxys-RN106909
Chemical Name Translation马来酸酐
Wiswesser Line NotationT5VOVJ
LabNetwork Molecule IDLN00193030
InChIInChI=1S/C4H2O3/c5-3-1-2-4(6)7-3/h1-2H
Canonical SMILESO=C1C=CC(O1)=O
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分类

  • {SNA} Anhydride Monomers, Materials Science, Monomers, Polymer Science
  • {uni_hamburg} no charge; oxygen heterocycle; aromatic; 5ring; carbo-anhydride; 1fragment
  • Heterocycles
  • {SNA} Anhydride Monomers, Monomers, Polymer Science, 材料科学
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {Chemicalbook} 农药中间体: 杀虫剂中间体: 有机磷类杀虫剂
  • {SNA} Building Blocks, Carbonyl Compounds, Carboxylic Acid Anhydrides, Chemical Synthesis, Organic Building Blocks

产品应用

  • Maleic Anhydride is heterocyclic compound used in the manufacture of unsaturated polyester resins. Maleic Anhydride has a wide range of other applications; it is used in synthetic tensides, insecticid

相关文献及参考

  • Short: II/19b
  • Reactive dienophile. For a review of its Diels-Alder reactions, see: Org. React., 4, 1 (1948). For examples, see: Org. Synth. Coll., 3, 807 (1955); 4, 890 (1963). For reaction with Danishefsky's diene (1-Methoxy-3-trimethyl­siloxy-1,3-butadiene, L14672), see: Org. Synth. Coll., 7, 312 (1990).
  • For use in combination with Urea hydrogen peroxide adduct, L13940, to generate peroxymaleic acid in epoxidation and Baeyer-Villiger reactions, see: Heterocycles, 36, 1075 (1993). Peroxymaleic acid can also be generated in situ from maleic anhydride and 30% H2O2 in NMP, and has been found to be a very effective oxidant for conversion of sulfides to sulfoxides. For a study of stoichiometric and catalytic oxidations with this system, see: J. Org. Chem., 61, 5693 (1996).
  • Short: II/14a
  • For thermal (2+2)-cycloaddition with allene at high temperature, see: Org. Synth. Coll., 5, 459 (1973).
  • Merck:14,5704
  • Merck:14,5704 Beilstein:17,432
  • Also undergoes photochemical and thermal (2+2)-cycloadditions with alkenes. For reaction with 1-alkynes, see: Chem. Ber., 102, 3974 (1969).
  • Hanafi, W.Z.A. et al.: Plast. Rub. Comp. Proc. Appl., 19, 175 (1993); Noma, K. et al.: Shik. Kyok., 36, 225 (1963); Augustin, M. et al.: Wissen. Zeitsch., 25, 5 (1976); Jiang, Q. et al.: Nongyao, 49,

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSON3675000
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P303+P361+P353
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P304+P340+P310
  • P305+P351+P338
  • P301+P330+P331+P310
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P342+P311
  • P403+P233
  • P305+P351+P338+P310
Signal word
Hazard Codes C
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R42/43
  • R22 Harmful if swallowed 吞咽有害
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
UN Number
Packing GroupIII
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Class8
Warnings 危化品目录(2015) 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1220 mg/kg/61W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   17,100,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 390 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,79,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >20 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
   National Cancer Institute, Memorandum, June 17, 1974
   Volume(issue)/page/year: 17JUN1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2620 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   42,417,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 465 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 230 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4060 mg/kg
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   7,359,1986

Restrict 危险品

其他信息

  • TCI Shanghai:顺丁烯二酸酐 Maleic Anhydride,>;99.0%(T)(108-31-6)
  • {Chem
  • {
  • 毒性分级:中毒
  • 下游产品:马来酸二丁酯 --> 乳液防水剂 --> DL-苹果酸 --> 马来酸二烯丙酯(Z)-2-丁烯二酸,二-2-丙烯基酯 --> 水溶性环氧树脂 --> 4-马来酰亚胺丁酸 --> 分散松香胶 --> 反丁烯二腈 --> 磺胺二甲基嘧啶 --> 屈 --> 阿西莫司 --> PR-I复鞣剂 --> 马来酸-醋酸乙烯酯共聚物 --> 6-羟基-2-苯基-3-哒酮 --> 哒嗪硫磷 --> WF-10加脂剂 --> 丁二酸烷酯聚乙氧基酯磺酸钠 --> 烯基琥珀酸酐 --> 马来酸二辛酯 --> 马来酸酐/苯乙烯磺酸共聚物 --> 水溶性树脂 --> N-乙基马来酰亚胺 --> 马来酸酯辛基锡 --> DL-天冬酰胺一水物 --> 2-十二烯基-丁二酸酐 --> 哒嗪-3，6-二醇 --> 十一碳烯酰胺 MEA磺基琥珀酸酯二钠 --> 二丁基马来酸锡 --> 造纸施胶剂 --> 丁二酸二钠(六水) --> 合成鞣剂DLT-14号 --> 降冰片烯二酸酐 -->
  • 敏感性:Moistu
  • 用途三:用于有
  • 蒸气压:0.16 mm Hg ( 20 °C)
  • 用途一:用作生产1,4-丁二醇、γ-丁内酯、四氢呋喃、琥珀酸、不饱和聚酯树脂、醇酸树脂等的原料，也
  • 方法一:顺酐的合成方法主要有苯氧化法、丁烯氧化法、丁烷氧化法等，目前生产上多数采用苯氧化法
  • 对湿敏感，易升华，溶于水成为失水苹果酸，能溶于丙酮、乙酸乙酯、氯仿、苯的甲苯，溶于醇形成酯，微溶于四氯化碳和粗挥汽油。
  • 方法一:顺酐的合成方法主要有苯氧化法、丁烯氧化法、丁烷氧化法等，目前生产上多数采用苯氧化法，即以苯为原料，经催化氧化得到顺酐。 采用固定床或沸腾床反应器，在V-Mo-P系催化剂作用下，用空气将苯氧化成顺丁烯二酸酐，反应温度为365℃。然后用水吸收生成顺丁烯二酸
  • 爆炸物危险特性:与空气混合可爆
  • 上游原料:苯 --> 二甲苯 --> 1-戊醇 --> 正丁烷 --> 压凝汽油
  • 蒸气密度:3.4 (vs air)
  • 马来酸酐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 10013118 顺丁烯二酸酐;失水苹果酸酐;2,5-呋喃二酮;马来酸酐;顺酐;二氢-2,5-二氧代呋喃;马来酐;顺丁二酸酐 500g 27元 2011/08/23 10013128 顺丁烯二酸酐;失水苹果酸酐;2,5-呋喃二酮;马来酸酐;顺酐;二氢-2,5-二氧代呋喃;马来酐;顺丁二酸酐 500g 25元 2011/04/16 M0005 顺丁烯二酸酐 Maleic Anhydride 25G 117元
  • 用途六:顺酐(108-31-6)是一种常用的重要基本有机化工原料。是世界上仅次于醋酐和苯酐的第三大酸酐原料。其下游产品有着相当广泛的开发和应用前景。顺酐(108-31-6)主要用于合成不饱和聚酯树酯，它是制造汽车部件、船舶、耐腐蚀性化工设备和日用品的原料。顺酐(108-31-6)也是生产润滑油的添加剂、涂料、农药、富马酸、共聚物、食品添加剂等重要中间体。其加氢衍生物有琥珀酸酐、1.4-丁二醇、r-J内酯和四氢呋喃.
  • 刺激数据:皮肤-兔子 500 毫克/24小时 轻度; 眼睛-兔子 1%/2分 重度
  • 用途五:主要用于生产不饱和聚酯树脂、醇酸树脂、农药马拉硫磷、高效低毒农药4049、长效碘胺的原料。也是涂料、马来松香、聚马来酐、顺酐-苯乙烯共聚物。也是生产油墨助剂、造纸助剂、增塑剂和酒石酸、富马酸、四氢呋喃等的有机化工原料。
  • 防护措施:有毒。其毒性比顺酸大，能刺激皮肤及粘膜。当人体接触高温液体时，其刺激性更为严重，能造成皮肤灼烧至伤，结膜、角膜红肿，严重时
  • MOL 文件:108-31-6.mol
  • 防护措施:有毒。其毒性比顺酸大，能刺激皮肤及粘膜。当人体接触高温液体时，其刺激性更为严重，能造成皮肤灼烧至伤，结膜、角膜红肿，严重时导致视力

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Analytical & Chromatography 分析化学与色谱
  2. Stable Isotopes 稳定同位素
  3. Alphabetical Listings for Stable Isotope Labeled Products
  4. M - Alphabetical Listings
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acid Anhydrides 羧酸酐
  1. Materials Science 材料科学
  2. Products for Polymer Science Research
  3. Monomers - Polymer Science
  4. Anhydride Monomers - Monomers
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carbonates
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Monomers
  4. Amine Monomers
  5. Tertiary Amines
  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. 医药合成催化剂