CAS 108-30-5 MFCD00005525-Succinic anhydride 丁二酸酐 TAO{mole}

Succinic anhydride 丁二酸酐

CAS 108-30-5 MFCD00005525

化学结构图

SMILES: O=C1CCC(=O)O1

化学属性

Mol. Formula	C4H4O3
Mol. Weight	100.07
Density	1.375
Vapor Density	3.5 (vs air)
Boiling Point	261°C at 760 mmHg
Vapor Pressure	1 mmHg ( 92 °C)
Melting Point	118-120°C
Flash Point	157°C
Solubility	不溶于水和乙醚，溶于氯仿。
TSCA	Yes
Appearance	常温下为白色正交锥形和双锥形结晶。稍有刺激性气味。不溶于水和乙醚，溶于氯仿。
Stability	对湿度敏感

别名和识别编码

Chemical Name	Succinic anhydride
CAS Number	108-30-5
Synonym	Succinic anhydride {LY} Succinic anhydride {} {LY} Succinic anhydride {} {} {LY} Succinic anhydride {} {} {} {LY} Succinic anhydride {} {} {} {} {LY} Succinic anhydride {} {} {} {} {} {LY} Succinic anhydride {} {} {} {} {} {} {LY} Succinic anhydride {} {} {} {} {} {} {} {LY} Succinic anhydride {} {} {} {} {} {} {} {} {LY} Succinic anhydride {} {} {} {} {} {} {} {} {} {LY} Succinic anhydride {} {} {} {} {} {} {} {} {} {} {LY} Succinic anhydride {} {} {} {} {} {} {} {} {} {} {} {LY} Succinic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succinic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succinic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succinic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succinic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
EC Number	203-570-0
Beilstein Registry Number	17,407
MDL Number	MFCD00005525
PubChem Substance ID	87575720
Merck Number	8870
Chemical Name Translation	丁二酸酐
Reaxys-RN	108441
Wiswesser Line Notation	T5VOVTJ
LabNetwork Molecule ID	LN00193512
Canonical SMILES	O=C(CC1)OC1=O

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产品应用

是涂料、医药、合成树脂和染料的原料。医药上用其生产维生素A和磺胺药等。农药上可用于生产杀菌剂、杀虫剂、植物生长调节剂。丁二酸酐还可生产增塑剂。在国防系统也有较多用途。

安全信息

Signal word Danger

GHS Symbol

WGK Germany1

Safety Statements

S46 If swallowed, seek medical advice immediately and show this container or label 食入时，立即求医并出示容器/标签；
S25 Avoid contact with eyes 避免眼睛接触；
S2 Keep out of the reach of children 避免儿童触及；

Risk Statements

R36/37 Irritating to eyes and respiratory system 对眼睛和呼吸系统有刺激性
R22 Harmful if swallowed 吞咽有害

Precautionary statements

P303+P361+P353+P310+P363
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P303+P361+P353
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P304+P340+P310
P305+P351+P338
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P304+P340+P312
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P405 Store locked up. 上锁保管。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P305+P351+P338+P310
P301+P330+P331+P310

RTECSWN0875000

Hazard statements

H335 May cause respiratory irritation 可能导致呼吸道刺激
H302 Harmful if swallowed 吞食有害
H319 Causes serious eye irritation 严重刺激眼睛
H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture Moisture Sensitive Store at 0-5°C {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {

Hazard Codes C Xn Xi,Xn

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2600 mg/kg/65W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   19,392,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1510 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0282-0433

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 130,97,1984

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 100 ug/L
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 19,642,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 79 mg/kg
SEX/DURATION            : female 8-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   2,61,1982

Hazard Class8

UN Number 3261

Packing GroupII

其他信息

用途六:是涂料、医药、合成树脂和染料的原料。医药上用其生产维生素A和磺胺药等。农药上可用于生产杀菌剂、杀虫剂、植物生长调节剂。丁二酸酐还
方法一:其制备方法有以下几种。 (1)顺酐催化加氢法以顺酐为原料，在钯/氧化铝催化下于160℃、5.88 MPa压力下，经加氢得产品，也可用铜的钼酸盐为催化剂，以1，4-二氧六环作溶剂，于120～160℃、20.26 MPa压力下加氢得到产品。丁二酸在普通精馏设备中在260℃左
对湿敏感。115℃(0.67kPa)升华。有刺激性,溶于乙醇、三氯甲烷和四氯化碳，微溶于水和乙醚。与热水可水解为丁二酸。
防护措施:低毒。生产中处理热的丁二酸或酐时，应戴活性炭防毒面罩及手套，以防刺激粘
Acros O
用途五:是涂料、医药、合成树脂和染料的原料。由其制造的涂料具有耐曲挠性和抗水性，医药上用其生产维生素A和磺胺药等。农药上可用于生产杀菌剂、杀虫剂、植物生长调节剂。丁二酸酐及其衍生物可用作烯烃聚合催化剂、酯类高分子缩合物的交联剂、高聚物的光稳定剂、紫外线
方法一:其制备方法有以下几种。 (1)顺酐催化加氢法以顺酐为原料，在钯/氧化铝催化下于160℃、5.88 MPa压力下，经加氢得产品，也可用铜的钼酸盐为催化剂，以1，4-二氧六环作溶剂，于120～160℃、20.26 MPa压力下加氢得到产品。丁二酸在普通精馏设备中在260℃左右脱水得产品，也可用化学脱水剂如乙酐、氯化亚砜、五氧化二磷等脱水，或用丁二酸加入一定量的四氢萘和甲苯，在200～212℃加热进行脱水得产品。
Alfa Aesar:丁二酸酐,99% Succinic anhydride, 99%
使用限量:适度为限(FDA，§172．892，2000)。
Sigma Aldrich:108-30-5(sigmaaldrich)
用途三:用于有机合成，是涂料用醇酸树脂、粘合树脂和蒽醌染料的原料，医药上用于生产维生素A和磺胺类药等
上游原料:三氯氧磷 --> 1,4-二氧六环 --> 氢 --> 酸性氧化铝 --> 马来酸酐 --> 丁二酸 --> 脱水剂 --> 1,2,3,4-四氢萘 --> 钼酸盐
所属类别一:食品添加剂: 酸度调节剂(PH调节剂): 酸化剂（酸味剂）
常规方法:用内衬塑料袋，外套编织袋包装。净重25kg。按一般化学品规定贮运。
参考质量标准:中国企标外观白色透明薄片熔点 118.3℃ 总酸度(OT-3) ≥99.5% 不饱和物 ≤0.5% 氯化物(以C1计，GT-8) ≤0.15% 5%水溶液浊度 ≤10号硫酸盐(以SO4 2- 计，GT-30) ≤0.04% 重金属(以Pb计，GT-16) ≤20mg/kg
MSDS 信息:Butanedioic anhydride(108-30-5).msds
图谱信息:丁二酸酐(108-30-5)质谱(MS) 丁二酸酐(108
用途二:用作分析试剂，也用于制药工业及酯类树脂的合成
下游产品:gamma-丁内酯 --> 4-氯苯丁酮 --> 4-(4-甲氧基苯基)丁酸 --> S-烯丙醇酮 --> 4-（2-噻嗯基）丁酸 --> 衣康酸 --> 1-芘丁酸 --> N-羟基丁二酰亚胺 --> 3-(2-噻吩甲基)丙酸 --> 4-(4-氨基苯基)丁酸 --> 丁二酸单甲酯(琥珀酸单甲酯) --> 伊马咪啶 --> 癸二酸二乙酯 --> 丁酰胺酸 --> 3-(4-氯苯甲酰)丙酸 --> 琥乙红霉素 --> 丁酰肼 --> 3-(4-氟苯甲酰)丙酸 --> 曲匹布通 --> 3-(4-甲氧基苯甲酰基)丙酸 --> 3-苯丙烯溴酸酯 --> 芬布芬 --> 哒菌清 --> 青蒿琥酯 --> 丁二酸单乙酯酰氯
上游原料:三氯氧磷 --> 1,4-二氧六环 --> 氢 --> 酸性氧化铝 --> 马来酸酐 --> 丁二酸 --> 脱水剂
用途四:丁二酸酐是杀菌剂菌核净和植物生长调节剂丁酰肼的中间体。
F:2