CAS 110-15-6 MFCD00002789-Succinic acid 琥珀酸 TAO{mole}

Succinic acid 琥珀酸

CAS 110-15-6 MFCD00002789

化学结构图

SMILES: O=C(O)CCC(=O)O

化学属性

Mol. Formula	C4H6O4
Mol. Weight	118.09
Density	1.56
Boiling Point	236.1 °C at 760 mmHg
Melting Point	185 °C
Flash Point	206°(402°F)
TSCA	Yes
Solubility	溶于水，微溶于乙醇、乙醚、丙酮、甘油。
Stability	对湿度敏感
Refractive index	n20/D 1.4002(lit.)
Danger-Level	-
pH	-:-
Redox	-

别名和识别编码

Chemical Name	Succinic acid
CAS Number	110-15-6
Synonym	Succinic acid {LY} Succinic acid {} {LY} Succinic acid {} {} {LY} Succinic acid {} {} {} {LY} Succinic acid {} {} {} {} {LY} Succinic acid {} {} {} {} {} {LY} Succinic acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succinic acid {} {} {} {} {} {} {} {LY} Succinic acid {} {} {} {} {} {} {} {} {LY} Succinic acid {} {} {} {} {} {} {} {} {} {LY} Succinic acid {} {} {} {} {} {} {} {} {} {} {LY} Succinic acid {} {} {} {} {} {} {} {} {} {} {} {LY} Succinic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succinic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succinic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succinic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succinic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Succinic acid {} {} {} {} {} {} {} {} {} {} {} {
MDL Number	MFCD00002789
EC Number	203-740-4
Beilstein Registry Number	1754069
Merck Number	8869
PubChem Substance ID	1110
Chemical Name Translation	琥珀酸
Reaxys-RN	1754069
Wiswesser Line Notation	QV2VQ
LabNetwork Molecule ID	LN00193188
InChI	InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
Canonical SMILES	O=C(O)CCC(O)=O

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产品应用

碱量法标准，检定铈、铜、镧、钍、镱、钇和亚硝酸盐，分离和测定铁和铝，缓冲剂，有机合成，气相色谱对比样品。

安全信息

Signal word Danger

GHS Symbol

WGK Germany1

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P350
P302+P352+P332+P313+P362+P364
P305+P351+P338
P305+P351+P338+P310
P305+P351+P338+P337+P313
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P332+P313
P337+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用

Hazard statements

H318 Causes serious eye damage 严重伤害眼睛
H315 Causes skin irritation 会刺激皮肤
H335 May cause respiratory irritation 可能导致呼吸道刺激
H303 May be harmfully swallowed 吞食可能有害

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

RTECSWM4900000

Hazard Codes Xi

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {}

UN Number UN 3265 8/PG 3

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book
   Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23,    1978-88. For
   publisher information, see ZYZAEU.  Volume(issue)/page/year: 18,100,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2702 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 62,203,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2260 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KODAK* Kodak Company Reports.  (343 State St., Rochester, NY 14650)
   Volume(issue)/page/year: #82-0158

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 20 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 183,89,1987

Restrict -

其他信息

用途六:碱量法标准，检定铈、铜、镧、钍、镱、钇和亚硝酸盐，分离和测定铁和铝，缓冲剂，有机合成，气相色谱对比样品。
{Chemica
用途四:丁二酸是杀菌剂菌核净和植物生长调节剂丁酰肼的中间体。
无气味，味极酸。易溶于热水、乙醇和甲醇，1g溶于13ml冷水、1ml沸水、18.5ml乙醇、6.3ml甲醇、36ml丙酮、20ml甘油、113ml乙醚，几乎不溶于苯、二硫化碳、四氯化碳和石油醚。0.1mol/L水溶液pH为2.7。最小致死量（硅，皮下）2000mg/kg。有刺激性。
Sigma Aldrich:110-15-6(sigmaaldrich)
下游产品:N-溴代丁二酰亚胺 --> 丁二酸酐 --> L-天门冬氨酸 --> N-氯代丁二酰亚胺 --> 戌二酸酐 --> RCF I/II型加脂剂 --> 丁二酰亚胺 --> 丁二酸二乙酯 --> 烯基丁二酸十七烯基咪唑啉盐,兰 703 --> 丁二酸二甲酯 --> 烷基酚聚氧惭烯醚磺化琥珀酸酯 --> 菌核净 --> 丁二酸二钠 --> 1,1'-二膦酸丙酸基膦酸钠 --> 丁二酰氯 --> 丁酰肼 --> alpha-酮戊二酸 --> TS-101清洗剂 --> 琥珀酸一钠
用途五:基本有机化工原料。主要用于涂料、染料、粘合剂和医药方面。由丁二酸生产的醇酸树脂具有良好的曲挠性、弹性和抗水性。丁二酸的二苯基酯是染料的
图谱信息:丁二酸(110-15-6)红外图谱(IR2) 丁二酸(110-15-6)质谱(MS) 丁二酸(110-15-6)红外图谱(IR1) 丁二酸(110-15-6)Raman光谱丁二酸(110-15-6)核磁图( 1 HNMR) 丁二酸(110-15-6)核磁图( 13 CNMR
防护措施:本品毒性较小，对皮肤有一定的刺激性，对全身不产生毒害作用。大鼠口服LD50为8530mg/kg。处理或接触丁二酸蒸汽时要注意穿戴好防护用品，以免引起咳嗽和刺激皮肤。
Alfa Aesar:丁二酸,ACS,99.0%min Succinic acid, ACS, 99.0% min(110-15-6)
上游原料:马来酸酐 --> 石蜡 --> 石脑油，原油 --> 富马酸 --> 马来酸 --> 毒草安 --> (2S,3S)-(+)-2,3-丁二醇 --> 贵金属
使用限量:GRAS(FDA，§184．1091，2000)。 ADI不作特殊规定(EEC，1990)。 LD 50 2260mg/kg(大鼠，经口)。
用途二:主要用于制取丁二酸酐、丁二酸酯类等衍生物，用作涂料、染料、粘合剂、药物等的原料
方法二:丁二酸除存在于琥珀外，还广泛存在于多种植物、动物的组织中。工业制法较多，主要有以下几种：1.氧化法石蜡经氧化生成各种羧酸的混合物，分离后可得丁二醇。2.加氢法顺丁烯二酸酐或反丁烯二酸在催化剂作用下加氢反应，生成丁二酸，然后经分离得到成品。催化剂为镍或贵金属，反应温度约为130-140℃。3.丙烯酸羰基合成法丙烯酸和一氧化碳在催化剂作用下，生成丁二酸。尚未工业化。4.电解氧化法苯酐与硫酸和水按1：0.5：4比例，在陶瓷电解槽中电解，可得丁二酸。5.乙炔法乙炔与一氧化碳及水在[CO(CO)4]催化剂存在下。反应温度80-250℃，压力2.94-49.03MPa，于酸性介质中反应可得丁二酸。
所属类别二:食品添
方法一:其制备方法是由顺丁烯二酸催化加氢，一般以兰尼镍作催化剂，也可用钯作催化剂，都可得到丁二酸。此外，在工业上可用石蜡氢化产品分离或用轻油在150～180℃、3.92～4.41 MPa压力下，在钴/镍催化剂存在下，用空气氧化，经分离可得丁二酸。
用途一:丁二酸在化学工业中用于生产染料、醇酸树脂、玻璃纤维增强塑料、离子交互树脂及农药等；在医药工业中用于合成镇静剂、避孕药及治癌物等，此外，还可用于分析试剂、食品铁质强化剂、调味剂等。包装与贮存：工业级编织袋内衬塑料袋。每袋净重25kg。精品（编织袋）或指定
常规方法:用编织袋或铁桶内衬塑料袋包装，每桶重100kg，袋装重25kg。贮存时要保持阴凉、干燥，防碱，防氧化剂。按一般化学品规定贮运。