CAS 62-55-5 MFCD00008070-Thioacetamide 硫代乙酰胺 TAO{mole}

Thioacetamide 硫代乙酰胺

CAS 62-55-5 MFCD00008070

化学结构图

SMILES: CC(N)=S

化学属性

Mol. Formula	C2H5NS
Mol. Weight	75.13
Melting Point	112-114°C
Density	1.37
Solubility	Soluble in water, ethanol
TSCA	Yes
Stability	对湿度敏感
Appearance	无色或白色结晶。熔点113-114℃，25℃水中的溶解度16.3g/100ml，乙醇26.4g/100ml。极微溶于苯、乙醚。其水溶液在室温或50-60℃时相当稳定，但当有氢离子存在时，很快产生硫代氢而分解。新制品有时有硫醇臭、微吸潮。
Boiling Point	111.7°C at 760 mmHg
Flash Point	21.4°C

别名和识别编码

Chemical Name	Thioacetamide
Synonym	Thioacetamide {LY} Thioacetamide {} {LY} Thioacetamide {} {} {LY} Thioacetamide {} {} {} {LY} Thioacetamide {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thioacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {
CAS Number	62-55-5
PubChem Substance ID	2723949
EC Number	200-541-4
Beilstein Registry Number	2,232
MDL Number	MFCD00008070
Reaxys-RN	506006
Merck Number	9319
Chemical Name Translation	硫代乙酰胺
Wiswesser Line Notation	ZY1&US
LabNetwork Molecule ID	LN00193918
InChI	InChI=1S/C2H5NS/c1-2(3)4/h1H3,(H2,3,4)
Canonical SMILES	CC(N)=S

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产品应用

用于分解氨基酸铜络合物。也用作聚合物的硫化剂、交联剂、橡胶助剂和医药原料。
肝毒素和致癌剂，用于β-酮基酯的异构选择性还原。

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H350 May cause cancer 可能致癌
H315 Causes skin irritation 会刺激皮肤
H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
H302 Harmful if swallowed 吞食有害
H319 Causes serious eye irritation 严重刺激眼睛

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes T

RTECSAC8925000

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P201 Obtain special instructions before use. 使用前获取专门指示。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P405 Store locked up. 上锁保管。
P308+P313
P301+P312+P330
P308+P311
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P273 Avoid release to the environment. 避免释放到环境中。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。

Signal word

Safety Statements

Risk Statements

R45 May cause cancer 可能致癌
R52/53
R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Packing GroupIII

UN Number

Storage condition 2-8°C, stored under nitrogen {LY} 2-8°C, stored under nitrogen RT, stored under nitrogen Store at RT. {} {LY} 2-8°C, stored under nitrogen {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under ni

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1600 mg/kg/12W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   28,1703,1968

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5140 mg/kg/47W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Reproductive - Tumorigenic effects - prostate tumors
REFERENCE :
   JPBAA7 Journal of Pathology and Bacteriology.  (London, UK)  V.1-96,
   1892-1968.  For publisher information, see JPTLAS. Volume(issue)/page/year:
   72,415,1956

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1008 mg/kg/9W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 175,257,1955

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 gm/kg/39W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   24,498,1970

{ha

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 301 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   27,380,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 12,447,1904

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 500 ug/L
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   52,1167,1974

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Am

TYPE OF TEST            : Morphological transformation
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 1512 mg/kg/6W
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 9,387,1988

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 100 ug/L
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 19,642,1977

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Primate - monkey Kidney
DOSE/DURATION           : 50 mg/L
REFERENCE :
   ECREAL Experimental Cell Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.10-    1950-  Volume(issue)/page/year: 57,193,1969

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 10 mg/L
REFERENCE :
   CYTZAM Cytobiologie.  (Stuttgart, Fed. Rep. Ger.)  V.1-18, 1969-79.  For
   publisher information, see EJCBDN.  Volume(issue)/page/year: 11,392,1975

{hazard_c

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H.,
   Paris, Masson et Cie, 1971  Volume(issue)/page/year: -,95,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 9-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - cytological changes (including
   somatic cell genetic material)
   Reproductive - Specific Developmental Abnormalities - hepatobiliary system
REFERENCE :
   FHCYAI Folia Histochemica et Cytochemica.  (Cracow, Poland)  V.1-21,
   1963-83.  Volume(issue)/page/year: 8,11,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1935 mg/kg
SEX/DURATION            : female 6-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB223-160

其他信息

上游原料:五硫化二磷 --> 乙酰胺
用途四:用于分解氨基酸铜络合物。也用作聚合物的硫化剂、交联剂、橡胶助剂和医药原料。肝毒素和致癌剂，用于β-酮基酯的异构选择性还原。
Alfa Aesar:硫代乙酰胺,ACS,99% Thioacetamide, ACS, 99%(62-55-5)
Acros Organics:硫代乙酰胺 Thioacetamide, 99+%(62-55-5)
用途三:用于生产催化剂、稳定剂、阻聚剂、电镀添加剂、照相药品、农药、染色助剂和选矿剂等。也用作聚合物的硫化剂、交联剂、橡胶助剂和医药原料。
Sigma Aldrich:62-55-5(sigmaaldrich)
海关编码:29309070
有轻微的硫醇臭。微吸湿。25℃时水中溶解度：16.3g/100ml，乙醇中溶解度：26.4g/100ml，微溶于乙醚。水溶液在或50～60℃时相当稳定，但当有氢离子存在时，很快分解产生硫化氢。最大吸收波长(水中)210、261、318nm(logε3.66、4.08、1.8)。有毒，最小致死量(大鼠，经口)200mg/kg。经试验表明，对实验动物有潜在致癌作用。有刺激性。
MOL 文件:62-55-5.mol
有机试剂:硫代乙酰胺又称乙硫酰胺，是一种有机试剂，无色或白色片状结晶。溶于水、乙醇，极微溶于苯、乙醚，其水溶液在室温或50～60℃时相当稳定，放置2～3周不变，但当有氢离子存在时，很快产生硫化氢而分解，但水解作用随着溶液的酸度或碱度增加以及温度升高而加快。硫代乙酰胺在酸性和碱性溶液中的水解反应方程式为：酸性溶液中：CH3CSNH2+2H2O----(NH4+)+CH3COO-+H2S 碱性溶液中：CH3CSNH2+2OH-----NH3+CH3COO-+HS- 由于在酸性或碱性溶液中水解生成H2S或HS-，故在分析化学中常被用来代替有毒和臭味的H2S，作为金属阳离子的组试剂或沉淀试剂。所得沉淀性质较好，易于分离。此外，亦可用作铋的测定试剂。制备方法：由乙酰胺与硫化铝加热、乙腈与硫化氢反应，或乙酰胺与K3PS4反应制取。
硫代乙酰胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30177714 硫代乙酰胺;乙硫酰胺 25g 35元 2011/04/16 T0187 硫代乙酰胺 Thioacetamide 25G 218元 2011/04/16 T0187 硫代乙酰胺 Thioacetamide 500G 1930元
方法一:乙腈与硫化氢反应，或使乙酰胺与五硫化二磷反应可制得硫代乙酰胺。
F:10
图谱信息:硫代乙酰胺(62-55-5)红外图谱(IR1) 硫代乙酰胺(62-55-5)红外图谱(IR2) 硫代乙酰胺(62-55-5)质谱(MS)
MSDS 信息:Ethanethioamide(62-55-5).msds
下游产品:2-(2,5-二甲基-1,3-噻唑-4-基)乙酸 --> 2,5-二甲基噻唑-4-乙酸甲酯 --> 2,4-二甲基-1,3-噻唑-5-羧酸 --> (2S,5R,6R)-6-[(2R)-2-[(2R)-2-氨基-3-(N-甲基氨基甲酰)-丙酰胺基]-2-(4-羟基苯基)乙酰胺基]-3,3-二甲基-7-氧代-4-硫-1-氮杂双环[3.2.0]庚烷-2-羧酸三水物 --> 2-甲基-1,3-噻唑-4-羧酸 --> 2-甲基噻唑-4-甲酸乙酯
用途二:用作聚合物的硫化剂及交联剂、橡胶助剂、医药原料等
用途一:用作分析试剂
TCI Shanghai:硫代乙酰胺 Thioacetamide,>;98.0%(GC)(T)(62-55-5)