CAS 109-65-9 MFCD00000260-1-Bromobutane 1-溴丁烷 TAO{mole}

1-Bromobutane 1-溴丁烷

CAS 109-65-9 MFCD00000260

化学结构图

SMILES: CCCCBr

化学属性

Mol. Formula	C4H9Br
Mol. Weight	137.02
Density	1.276
Autoignition Point	509 °F
Refractive index	1.4380 to 1.4420
Vapor Density	4.7 (vs air)
Boiling Point	101°C
Vapor Pressure	150 mmHg ( 50 °C)
Melting Point	-112
Flash Point	13°C
TSCA	Yes
Solubility	不溶于水，溶于乙醇、乙醚。
Stability	对光敏感

别名和识别编码

Chemical Name	1-Bromobutane
MDL Number	MFCD00000260
CAS Number	109-65-9
EC Number	203-691-9
Beilstein Registry Number	1,119
Synonym	1-Bromobutane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID	8002
Merck Number	1553
Reaxys-RN	1098260
Chemical Name Translation	1-溴丁烷
Wiswesser Line Notation	E4
LabNetwork Molecule ID	LN00196048
InChI	InChI=1S/C4H9Br/c1-2-3-4-5/h2-4H2,1H3
Canonical SMILES	CCCCBr

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产品应用

用于合成麻醉药盐酸丁卡因；也用于生产染料和香料。

安全信息

Signal word Danger

GHS Symbol

WGK Germany2

Safety Statements

S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R10 Flammable 易燃
R51/53
R11 Highly flammable 非常易燃

Precautionary statements

P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P273 Avoid release to the environment. 避免释放到环境中。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P337+P313
P403+P235
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P332+P313
P501 Dispose of contents/container to..… 处理内容物/容器.....
P308+P313
P302+P352+P332+P313+P362+P364
P303+P361+P353
P201 Obtain special instructions before use. 使用前获取专门指示。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P305+P351+P338+P337+P313
P241+P242+P243
P405 Store locked up. 上锁保管。
P233 Keep container tightly closed. ?保持容器密闭。

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
H335 May cause respiratory irritation 可能导致呼吸道刺激
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H319 Causes serious eye irritation 严重刺激眼睛

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSEJ6225000

Packing GroupII

UN Number UN 1126 3/PG 2 UN1126 1126

Hazard Codes 3

Storage condition +4°C 2-8°C Store at room temperature {} {} {} {} {} {} { {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {

Hazard Class3

Warnings 危化品目录(2015)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1424 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 20(12),52,1976

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 25800 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 18(4),55,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPCEAO Journal fuer Praktische Chemie.  (Johann Ambrosius Barth Verlag,
   Postfach 109, Leipzig DDR-7010, Ger. Dem. Rep.)  V.1-    1834-
   Volume(issue)/page/year: 320,133,1978

Restrict 危险品

其他信息

特性:溴丁烷（109-65-9）性质稳定，但在常温下易
下游产品:正丁基锂 --> 二正丁胺 --> 异氰酸正丁酯 --> 荧光增白剂 185 --> 正己醇 --> 正戊酸 --> 二丁基氧化锡 --> 2-甲基己酸 --> 1-丁基-3-甲基咪唑六氟磷酸盐 --> 4-正丁氧基苯酚 --> 三丁基膦 --> 正辛烷 --> 丁苯 --> 1-丁基-3-甲基咪唑四氟硼酸盐 --> 二甲嘧酚 --> 啶虫脒 --> 奥布卡因盐酸盐 --> 戊腈 --> 1-丁基哌嗪 --> 4-氨基苯丁醚 --> 丁硫醇 --> 卤方特瑞 --> 测试 --> 4-甲基-2-噻吩甲酸 --> 4-(正丁基氨基)苯甲酸乙酯 --> 2-正丁基乙酰乙酸乙酯 --> 1-丁基-3-甲基咪唑溴盐 --> 二丁基硫醚 --> 苯佐那酯 --> 顺式-3-辛烯-1-醇 --> 4-丁氧基苯甲酸 --> 丁氧基苯
PH值:6.0～8.0
TCI Shanghai:溴代正丁烷 1-
毒性分级:中毒
MOL 文件:109-65-9.mol
方法一:其制备方法是将正丁醇、溴化钠、水、硫酸搅拌均匀，加热回流3h，蒸出粗品溴丁烷，用水洗涤，用冷浓硫酸处理，进行蒸馏得成品。反应方程式：CH 3 CH 2 CH 2 CH 2 OH+NaBr+H 2 SO 4 →CH 3 CH 2 CH 2 CH 2 Br+Na 2 SO 4 +H 2 O
灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
储运特性:库房通风低温干燥; 与氧化剂分开存放
溴丁烷价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80024428 溴代正丁烷 500ml 64.9元 2011/04/16 B0560 1-溴丁烷 1-Bromobutane 25G 150元 2011/04/16 B0560 1-溴丁烷 1-Bromob
用途二:用作稀有元素萃取剂、烃化剂及有机合成原料，还可用作医药、染料和香料的原料
图谱信息:溴丁烷(109-65-9)红外图谱(IR1) 溴丁烷(109-65-9)质谱(MS) 溴丁烷(109-65-9)核磁图( 13 CNMR) 溴丁烷(109-65-9)红外图谱(IR2)
上游原料:氢溴酸 -->
不溶于水，水中溶解度:0.608 g/l (30°C)，易溶于醇、醚、丙酮、氯仿、苯和CCl4。性质稳定，但在常温下易起火，起火时无化学反应发生。能刺激皮肤。
可燃性危险特性:遇明火、高温、氧化剂易燃; 高热分解有毒溴化物气体
用途四:用于合成麻醉药盐酸丁卡因，也用于生产染料和香料。
用途一:用作医药、染料、农药中间体
不挥发物:≤50PPM
方法二:由正丁醇在红磷存在下与溴作用而得；或由正丁醇在硫酸存在下与氢溴酸反应而得。正丁醇与氢溴酸混合，滴加入硫酸，加热回流反应1.5h，蒸馏得溴丁烷粗品，用水洗至pH为6-7，用无水氯化钙脱水即得。
类别:易燃液体
用途五:用于合成麻醉药盐酸丁卡因；也用于生产染料和香料。
蒸气密度:4.7 (vs air)
爆炸物危险特性:与空气混合可爆
Alfa Aesar:1-溴丁烷,98+% 1-Bromobutane, 98+%(109-65-9)
急性毒性:腹腔- 大鼠 LD50: 4450 毫克/ 公斤; 腹腔- 小鼠 LD50: 1424 毫克/ 公斤
蒸气压:150 mm Hg ( 50 °C)
Acros Organics:1-溴丁烷 1-Bromobutane, 99%(109-65-9)
Sigma Aldrich:109-65-9(sigmaaldrich)
用途三:1-溴丁烷是杀菌剂二甲嘧酚和乙嘧酚的中间体。