CAS 106-49-0 MFCD00007906-P-Toluidine 对甲基苯胺 TAO{mole}

P-Toluidine 对甲基苯胺

CAS 106-49-0 MFCD00007906

化学结构图

SMILES: CC1CCC(N)CC1

化学属性

Mol. Formula	C7H9N
Mol. Weight	107.15
Density	0.973
Autoignition Point	899 °F
Vapor Density	3.9 (vs air)
Boiling Point	200
Vapor Pressure	0.26 mmHg ( 25 °C)
Melting Point	41-46
Flash Point	88.89°C
TSCA	Yes
Refractive index	1.5532
Solubility	微溶于水，溶于乙醇、乙醚、苯、盐酸。
Stability	对热，光和空气敏感
Appearance	powder

别名和识别编码

Chemical Name	P-Toluidine
CAS Number	106-49-0
Synonym	p-Toluidine {LY} p-Toluidine {} {LY} p-Toluidine {} {} {LY} p-Toluidine {} {} {} {LY} p-Toluidine {} {} {} {} {LY} p-Toluidine {} {} {} {} {} {LY} p-Toluidine {} {} {} {} {} {} {LY} p-Toluidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Toluidine {} {} {} {} {} {} {} {} {LY} p-Toluidine {} {} {} {} {} {} {} {} {} {LY} p-Toluidine {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} p-Toluidine {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} p-Toluidine {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Toluidine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Toluidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Toluidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Toluidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Toluidine {} {} {} {} {} {} {} {} {} {} {}
MDL Number	MFCD00007906
EC Number	203-403-1
Beilstein Registry Number	471281
PubChem Substance ID	7813
Merck Number	9536
Reaxys-RN	471281
Chemical Name Translation	对甲基苯胺
Wiswesser Line Notation	ZR D1
LabNetwork Molecule ID	LN00197991
InChI	InChI=1S/C7H9N/c1-6-2-4-7(8)5-3-6/h2-5H,8H2,1H3
Canonical SMILES	NC1=CC=C(C)C=C1

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

光度测定金、钛（Ⅲ）、钨。检定金、银、锇、铂、硝酸盐、亚硝酸盐、间苯三酚和木质素。测定羧酸和磺酸。测定分子量的溶剂。有机合成用于生产4B酸及合成染料。

安全信息

Signal word Danger

GHS Symbol

WGK Germany2

Safety Statements

S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R36 Irritating to eyes 刺激眼睛
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R50 Very toxic to aquatic organisms 对水生生物极毒

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P310
P301+P310+P330
P301+P312+P330
P302+P350
P304+P340+P312
P305+P351+P338
P308+P313
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P337+P313
P342+P311
P403+
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H331 Toxic if inhaled 吸入中毒
H311 Toxic in contact with skin 皮肤接触中毒
H301 Toxic if swallowed 吞食有毒
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H351 Suspected of causing cancer 怀疑致癌
H319 Causes serious eye irritation 严重刺激眼睛
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H301+H311+H331
H302 Harmful if swallowed 吞食有害

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RTECSXU3150000

Packing GroupII

UN Number 3451 UN3451

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

Hazard Codes 6.1 T,N

Hazard Class6.1

Warnings 危化品目录(2015)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 336 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   BCTKAG Bromatologia i Chemia Toksykologiczna.  (Ars Polona, POB 1001, 00-068
   Warsaw 1, Poland) V.4-    1971-  Volume(issue)/page/year: 17,51,1984

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >640 mg/m3/1H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets.  (1810
   Frontage Rd., Northbrook, IL 60062)  Volume(issue)/page/year: 31-4/1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 330 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher inf

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 46,305,1977

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 5,355,1982

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 5,803,1983

Restrict 危险品

其他信息

Acros Organics:对甲基苯胺 p-Toluidine, flakes, 99%(106-49-0)
灭火剂:干粉、泡沫、二氧化碳、砂土、雾状水
图谱信息:对甲苯胺(106-49-0)红外图谱(IR1) 对甲苯胺(106-49-0)红外图谱(IR3) 对甲苯胺(106-49-0)核磁图( 1 HNMR) 对甲苯胺(106-49-0)质谱(MS) 对甲苯胺(106-49-0)红外图谱(IR2) 对甲苯胺(106-49-0)核磁图( 13 CNMR)
MOL 文件:106-49-0.mol
上游原料:硫化钠 --> 4-硝基甲苯 --> 九水硫化钠
对甲苯胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80131417 对甲苯胺;4-氨基甲苯;4-甲基苯胺;对叨胺;对氨基甲苯 250g 42元 2011/04/16 T0300 对甲苯胺 p-Toluidine 500G 820元 2011/0
检测方法:GC,NMR
类别:有毒物品
急性毒性:口服-大鼠 LD50: 336 毫克/公斤; 口服-小鼠 LD50: 330 毫克/公斤
方法一:由对硝基甲苯在124-126℃、0.2MPa表压下，用硫化钠还原制得对甲苯胺，反应液静置分层，分去水层，然后经减压蒸馏、冷凝、结晶、干燥，得成品
刺激数据:皮肤-兔子 500 毫克/24小时重度; 眼睛-兔子 20 毫克/24小时中度
Sigma Aldrich:106-49-0(sigmaaldrich)
对光敏感。易溶于醇、醚、丙酮、甲醇、二硫化碳、油类和稀酸，微溶于水。低毒，半数致死量（大鼠，经口）656mg/kg。溶于稀无机酸并生成盐。
蒸气密度:3.9 (vs air)
图谱信息:对甲苯胺(106-49-0)红外图谱(IR1) 对甲苯
外观性质:纯品为无色片状结晶。
用途四:光度测定金、钛（Ⅲ）、钨。检定金、银、锇、铂、硝酸盐、亚硝酸盐、间苯三酚和木质素。
蒸气压:0.26 mm Hg ( 25 °C)
F:8-23
职业标准:TWA 9 毫克/立方米;
下游产品:对氯甲苯 --> 依达拉奉 --> 对溴甲苯 --> 对三氟甲基苯胺 --> 颜料红 122 --> 3-硝基甲苯 --> 4-甲基-2-硝基苯胺 --> 喹啉-6-甲醛 --> 6-羟甲基喹啉 --> 盐基品红 --> 4-氨基甲苯-3-磺酸 --> 对氟甲苯 --> 2-(4-氨基苯基)-6-甲基苯并噻唑-7-磺酸 --> 弱酸绿GS --> 2-硝基-4-甲苯酚 --> 1-(4-甲基苯基)哌嗪 --> 1R-顺式二氯菊酸 --> 酸性绿 25 --> 4-氟三氟甲苯 --> 对甲基间羟基二苯胺 --> 4-氨基甲苯-2-磺酸 --> 3,5-二硝基甲苯
常规方法:采用铁桶包装，每桶净重180kg。贮存于干燥、通风处，防热、防潮、防晒。按有毒物品规定贮运。
用途三:主要作为染料中间体，用以制作红色基GL、甲基胺红色淀、碱性品红，甲基周位酸及4-氨基甲苯-3-磺酸，三苯基甲烷染料和噁嗪染料等。亦作为医药乙胺嘧啶、农药杀草隆等产品的中间体。
color:tan to brown
防护措施:有毒。有致癌性。家兔中枢神经系统最低
储运特性:库房通风低温干燥; 与氧化剂、食品添加剂分开存放
海关编码:38220000
Alfa Aesar:对甲苯胺,99+% p-Toluidine, 99+%(106-49-0)
毒性分级:高毒
TCI Shanghai:对甲基苯胺 p-Toluidine,>
用途二:用作染料、医药、农药中间体