CAS 95-53-4 MFCD00007730-o-Toluidine 邻甲苯胺 TAO{mole}

o-Toluidine 邻甲苯胺

CAS 95-53-4 MFCD00007730

化学结构图

SMILES: Cc1ccccc1N

化学属性

Mol. Formula	C7H9N
Mol. Weight	107
Density	1.008
Refractive index	1.5710 to 1.5740
Autoignition Point	899 °F
Vapor Density	3.7 (vs air)
Boiling Point	89-90
Vapor Pressure	0.26 mmHg ( 25 °C)
Melting Point	-28
Flash Point	86°C(lit.)
TSCA	Yes
Solubility	1.5 G/100 ML (25 ºC)
Stability	对光敏感
Appearance	liquid
pH	:A

别名和识别编码

Chemical Name	o-Toluidine
CAS Number	95-53-4
Synonym	o-Toluidine 2-Amino-1-methylbenzene 2-methyl-Benzenamine 2-amino-1-methylbenzene 1-Amino-2-methylbenzene; 1-Methyl-2-aminobenzene; 2-Aminotoluene; 2-Methylaniline 2-Aminotoluene, 2-Methylaniline 2-Methylbenzenamine 2-aminotoluene 鄰甲苯胺 039-01 [6] o-Aminotolue O-toluidine 2-Aminotoluene 2-甲基苯胺 2-氨基甲苯,2-甲基苯胺,邻氨基甲苯 benzenamine, 2-methyl- o-Aminotoluol (2-methylphenyl)amine 2-methylphenylamine ORTHO-TOLUIDINE O-TOLUIDINE REAGENT o-Aminotoluene aniline,2-methyl- 2-Toluidine 2-methylbenzamine 邻甲苯胺/2-甲基苯胺 2-methylaniline AKOS BBS-00004267
MDL Number	MFCD00007730
EC Number	202-429-0
Beilstein Registry Number	741981
PubChem Substance ID	7242
Merck Number	9536
Reaxys-RN	741981
Chemical Name Translation	邻甲苯胺
Wiswesser Line Notation	ZR B1
LabNetwork Molecule ID	LN00194951
InChI	InChI=1S/C7H9N/c1-6-4-2-3-5-7(6)8/h2-5H,8H2,1H3

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产品应用

测定铈、镧、钕、镨、钍和锆时的沉淀剂, 检定氰化氢、铱、镍、锇、钯、铂、钒、铬、金、银、游离氯和双氧水, 测定矿物折射率的浸渍液、有机合成。

安全信息

Signal word

GHS Symbol

WGK Germany3

Safety Statements

Risk Statements

R45 May cause cancer 可能致癌
R36 Irritating to eyes 刺激眼睛
R50 Very toxic to aquatic organisms 对水生生物极毒
R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P303+P361+P353
P308+P313
P304+P340+P310
P305+P351+P338
P201 Obtain special instructions before use. 使用前获取专门指示。
P337+P313
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P332+P313
P501 Dispose of contents/container to..… 处理内容物/容器.....
P370+P378
P301+P312+P330
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P273 Avoid release to the environment. 避免释放到环境中。
P301+P310
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P403+P233

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Hazard statements

H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H350 May cause cancer 可能致癌
H302 Harmful if swallowed 吞食有害
H226 Flammable liquid and vapour 易燃液体和蒸气
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H301+H331
H319 Causes serious eye irritation 严重刺激眼睛
H331 Toxic if inhaled 吸入中毒
H301 Toxic if swallowed 吞食有毒
H227 Combustible liquid 可燃液体

RTECSXU2975000

Packing GroupII

UN Number

Storage condition 密封阴凉避光保存。 Air & Light Sensitive 2-8°C

Hazard Codes T,N T,N,F

Hazard Class6.1

Warnings 危化品目录(2015)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 840 mg/kg/14W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,155,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
                          female 15-21 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
REFERENCE :
   BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
   Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.41-    1956-  Volume(issue)/page/year: 78,1402,1974

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7250 mg/kg/23W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   APMIAL Acta Pathologica et Microbiologica Scandinavica.  (Copenhagen,
   Denmark)  V.1-77, 1924-69.  For publisher information, see ACPADQ.
   Volume(issue)/page/year: 26,447,1949

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 109 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Blood - tumors
REF

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - pigmented or nucleated red blood cells
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,155,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 840 mg/kg
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - pigmented or nucleated red blood cells
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,155,1982

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Lungs, Thorax, or Respiration - dyspnea
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   XPHBAO U.S. Public Health Service, Public Health Bulletin.  (Washington, DC)
    Volume(issue)/page/year: 271,49,1941

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 1700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 125 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   5,451,1985

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   5,587,1985

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 40 ug/plate
REFERENCE :
   PJABDW Proceedings of the Japan Academy, Series B: Physical and Biological
   Sciences.  (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31,
   Japan)  V.53-    1977-  Volume(issue)/page/year: 53,34,1977

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 5,355,1982

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 2500 umol/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   5,469,1985

{hazard_c

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 9520 mg/kg
SEX/DURATION            : female 17 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - physical
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 27(9),47,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 9520 mg/kg
SEX/DURATION            : male 17 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Effects on Newborn - physical
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 27(9),47,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 952 mg/kg
SEX/DURATION            : female 17 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and

Restrict 危险品

其他信息

MSDS 信息:2-甲基苯胺(95-53-4).msds
外观性质:无色或淡黄色油状液体。
图谱信息:邻甲基苯胺(95-53-4)核磁图( 13 CNMR) 邻甲基苯胺(95-53-4)质谱(MS) 邻甲基苯胺(95-53-4)红外图谱(IR2) 邻甲基苯胺(95-
蒸气密度:3.7 (vs air)
毒性分级:中毒
甲苯胺异构体:甲苯胺有3种异构体，即邻甲基苯胺、间甲基苯胺和对甲基苯胺，邻甲苯胺为原位取代产物，间甲苯胺为移位取代产物。邻甲苯胺又称“邻氨基甲苯”，为无色至浅黄色液体，曝露在空气中及光照下变为红棕色，遇甲醛生成白色沉淀。微溶于水，溶于稀酸、醇、醚中。相对密度：1.004(20℃)；熔点：-16.3℃ (β型)，-24.4℃(α型)；沸点：199.7℃; 闪点：85℃；自燃点：482.2℃；蒸汽密度：3.69。其蒸汽与空气可形成爆炸性混合物，在空气中的最高容许浓度为5ppm。遇明火能燃烧，受高热会散发有毒气体，毒性与苯胺相似，进入体内容易形成高铁血红蛋白，而发生神经性障碍及发绀。邻甲苯胺是生产染料及颜料的重要中间体，可用于制备直接红62，红色基RL、大红色基G、枣红色基GBC、碱性品红、色酚AS-D、酸性红35、158、265，溶剂红124，偶氮染料的重氮组分及偶合组分，制有机颜料黄14、17、蓝19；农药原料，生产农药杀菌剂“三环唑”，杀虫剂螟蛉畏、杀虫脒；除草剂乙草胺；橡胶硫化促进剂的原料；糖精原料；缓蚀剂原料等。在
危险情况:(1) 邻甲苯胺有毒，吸入蒸气，或经皮肤吸收或摄入均会引起中毒。是已知致癌物。 (2) 易燃，燃点482℃，蒸气能与空气形成爆炸性混合物。空气中的容许浓度美国为2ppm (9mg/m3)。
测定方法:在空气中的测定：用硅石吸附，正丙醇处理，气相色谱法分析。
{Chemica
露置空气中或见光逐渐变成浅红棕色, 能随水蒸气挥发。能溶于醇、醚和稀酸，微溶于水。低毒，半数致死量(大鼠，经口)670mg/kg。有致癌可能性。有刺激性。
Sigma Aldrich:95-53-4(sigmaaldrich)
灭火剂:雾状水, 泡沫
贮存:用玻璃瓶或金属桶盛装，防止机械性损坏。放在阴凉、干燥、通风良好的地方。最好使用露天或附建的仓库，严禁烟火，远离容易起火地点，避光、密封保存。与氧化剂隔开。
存储注意事项:氮气保护;空气敏感
爆炸物危险特性:与空气混合可爆
下游产品:8-甲基喹啉 --> 2-甲基-6-乙基苯胺 --> 3-碘吲唑 --> 硫化黄GC --> 硫化褐 10号 --> 3-溴吲唑 --> 硫化蓝7 --> 2-溴甲苯 --> 冰染偶合组分 18 --> N-甲基-邻甲基苯胺 --> 盐基品红 --> 4-氯-2-甲基苯胺 --> 氯唑西林钠 --> 叔戊酰邻甲基苯胺 --> 弱酸性亮红10b --> 2'-甲基乙酰乙酰苯胺 --> 2-甲基乙酰苯胺 --> 3-硝基吲唑 --> 碱性品红 --> 盐酸溴己新 --> 溴苄乙胺 --> 冰染重氮组分 34 --> N-邻甲苯基硫脲 --> 1-(2-甲基苯基)哌嗪 --> 仲戊醇 --> 2,4-二溴-6-甲基苯胺 --> 杀虫脒 --> 溴甲酚紫 --> 1-(2-甲基苯基)哌嗪盐酸盐 --> N,N-二乙基-邻甲基苯
常规方法:采用铁桶包装。贮存于阴凉、通风的仓库内，严禁烟火。按有毒化学品规定贮运。
下游产品:8-甲基喹啉 --> 2-甲基-6-
用途一:用作分析试剂和染料中间体，也用于有机合成
类别:有毒物品
制备方法:1，在稀酸介质中，用邻硝基甲苯与铁粉
用途二:用作染料、农药、医药及有机合成中间体
急救:此化学品如进入眼中，立即用水或洗眼剂冲洗; 如接触皮肤，立即用肥皂和水洗净; 如有人大量吸入，立即移离现场
color:light yellow to light amber
用