CAS 108-42-9 MFCD00007765-3-Chloroaniline 3-氯苯胺 TAO{mole}

3-Chloroaniline 3-氯苯胺

CAS 108-42-9 MFCD00007765

化学结构图

SMILES: Nc1cccc(Cl)c1

化学属性

Mol. Formula	C6H6ClN
Mol. Weight	127.57
Refractive index	1.5920 to 1.5960
Boiling Point	-
Density	1.206
Melting Point	−11-−9
Flash Point	-
TSCA	Yes
Vapor Pressure	1 mmHg ( 63.5 °C)
Solubility	不溶于水，溶于多数有机溶剂。
Stability	对光敏感

别名和识别编码

Chemical Name	3-Chloroaniline
CAS Number	108-42-9
PubChem Substance ID	7932
EC Number	203-581-0
Beilstein Registry Number	12,602
MDL Number	-
Reaxys-RN	605969
Merck Number	2118
Synonym	m-Chloroaniline {LY} m-Chloroaniline {} {LY} m-Chloroaniline {} {} {LY} m-Chloroaniline {} {} {} {LY} m-Chloroaniline {} {} {} {} {LY} m-Chloroaniline {} {} {} {} {} {LY} m-Chloroaniline {} {} {} {} {} {} {LY} m-Chloroaniline {} {} {} {} {} {} {} {LY} m-Chloroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} m-Chloroaniline {} {} {} {} {} {} {} {} {} {LY} m-Chloroaniline {} {} {} {} {} {} {} {} {} {} {LY} m-Chloroaniline {} {} {} {} {} {} {} {} {} {} {} {LY} m-Chloroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} m-Chloroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} m-Chloroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} m-Chloroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} m-Chloroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} m-Chloroaniline
Chemical Name Translation	3-氯苯胺
Wiswesser Line Notation	ZR CG
LabNetwork Molecule ID	LN00221111
InChI	InChI=1S/C6H6ClN/c7-5-2-1-3-6(8)4-5/h1-4H,8H2
Canonical SMILES	NC1=CC=CC(Cl)=C1

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产品应用

有机合成。偶氮染料、颜料、药物、杀虫剂、农业化学品的中间体。

安全信息

GHS Symbol

WGK Germany2

Hazard statements

H301+H311+H331
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
H331 Toxic if inhaled 吸入中毒
H311 Toxic in contact with skin 皮肤接触中毒
H301 Toxic if swallowed 吞食有毒

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Hazard Codes T,N

RTECSBX0350000

Precautionary statements

P273 Avoid release to the environment. 避免释放到环境中。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P301+P310
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P305+P351+P338
P332+P313
P307+P311
P302+P350
P337+P313
P403+P233
P302+P352+P312
P304+P340+P312
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P304+P340+P311

Signal word

Safety Statements

S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R33 Danger of cumulative effects 有累积作用的危险
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R50/53
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

UN Number UN 2019 6.1/PG 2 2019

Packing GroupII

Storage condition 2-8°C {LY} 2-8°C 4°C, Inert atmosphere {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C

Hazard Class6.1

Warnings 危化品目录(2015)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TSCAT* Office of Toxic Substances Report.  (U.S. Environmental Protection
   Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
   Volume(issue)/page/year: OTS 206512

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Vo

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TSCAT* Office of Toxic Substances Report.  (U.S. Environmental Protection
   Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
   Volume(issue)/page/year: OTS 206512

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 223 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 13(5),29,1969

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 200 mg/L
REFERENCE :
   CJMIAZ Canadian Journal of Microbiology.  (National Research Council of
   Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 
     1954-  Volume(issue)/page/year: 16,369,1970

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 300 ug/L
REFERENCE :
   BLFSBY Basic Life Sciences.  (Plenum Pub. Corp., 223 Spring St., New York,
   NY 10003)  V.1-    1973-  Volume(issue)/page/year: 39,359,1986

Restrict 危险品

其他信息

灭火剂:二氧化碳、泡沫、干粉、雾状水
Alfa Aesar:3-氯苯胺,99% 3-Chloroaniline, 99%(108-42-9)
{Chem
TCI Shanghai:3-氯苯胺 3-Chloroaniline,>;99.0%(GC)(108-42-9)
MOL 文件:108-42-9.mol
外观性质:无色液体到淡琥珀色液体。
蒸气压:1 mm Hg ( 63.5 °C)
Hazard Note:Toxic
MSDS 信息:间氯苯胺(108-42-9).msds
用途三:间氯苯胺是除草剂
Sigma Aldrich:108-42-9(sigmaaldrich)
防护措施:有毒。吞咽、吸入或经皮肤吸收均可引起中毒。具有溶血性，甚至能引起膀胱癌。急性中毒时，呈现昏迷，发绀，严重休克。生产设备应密闭，生产现场应保持良好的通风。操作人员应穿戴各种劳保用具，勤洗工作服，加强营养。
图谱信息:3-氯苯胺(108-42-9)红外图谱(IR1) 3-氯苯胺(108-42-9)核磁图( 1 HNMR) 3-氯苯胺(
类别:有毒物品
3-氯苯胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80032426 间氯苯胺 100ml 68元 2011/04/16 C0110 3-氯苯胺 3-Chloroaniline 25ML 142元 2011/04/16 C0110 3-氯苯胺 3-Chloroaniline 500ML 776元
用途三:间氯苯胺是除草剂氯苯胺灵的中间体，也是医药利尿降压药双氢氯噻嗪的中间体，并可用于生产偶氮
Acros Organics:3-氯苯胺 3-Chloroaniline, 99%(108-42-9)
可燃性危险特性:遇明火可燃; 燃烧产生有毒氮氧化物和氯化物烟雾
储运特性:库房通风低温干燥; 与氧化剂、酸类、食品添加剂分开存放
海关编码:29214210
上游原料:硫化钠 --> 3-硝基氯苯 --> 亚铁
对光、空气敏感。遇光或储藏时颜色变深。微溶于水，水中溶解度：6.8g/L(20°C) ，能溶于大多数有机溶剂。
下游产品:1,3-二氯苯 --> 苯硫咪唑 --> 3-氯苯酚 --> 荧光增白剂31号 --> 硝酸咪康唑 --> 1-(3-氯苯基)哌嗪盐酸盐 --> 1-(3-氯苯基)-4-(3-氯丙基)哌嗪盐酸盐 --> 4-溴-3-氯乙酰苯胺 --> 色基橙GC --> 7-氯-4-羟基喹啉 --> 间氯苯胺盐酸盐 --> 间氯苯异氰酸酯 --> 7-氯-1,4-二氢-4-氧代-3-喹啉羧酸乙酯 --> 间氯二苯胺 --> 氯灭酸 --> 燕麦灵 --> 5-氯-2,4-二磺酰胺基苯胺 --> 双氢氯噻嗪 --> 非班太尔 --> 4-氨基-6-氯-1,3-苯二磺酰氯
F:8-10-23
用途一:用于有机合成
方法一:其制备方法是用间氯硝基苯还原制得，还原剂可用硫化钠或锌粉和盐酸，在反应釜中，硫化钠加水溶解后搅拌加热沸腾，逐渐加人间氯硝基苯，回流5 h后，蒸馏分取油状液得成品。
毒性分级:高毒
用途二:主要用于棉、麻、粘胶织物的染色和印花的显影剂，在医药上可制抗精神病药物盐酸氯丙嗪及奋乃静等
方法二:由间硝基氯苯在硫酸亚铁存在下用铁粉还原而得：也可以用硫化碱还原，还原反应后经中和，水蒸汽蒸馏，减压蒸馏得成品。工业品为微黄色至浅棕色油状液体，含量≥99%。原料消耗定额：间硝基氯苯1300kg/t、硫化碱960kg/t。
用途四:用作染料、农药、医药的中间体，其盐酸盐为冰染染料色基，主要用于棉、麻、粘胶织物的染色和印花的显色剂，在医药上可制氯丙嗪、磷酸氯喹等。也可制杀虫剂等。