CAS 95-54-5 MFCD00007721-1,2-Phenylenediamine 1,2-苯二胺 TAO{mole}

1,2-Phenylenediamine 1,2-苯二胺

CAS 95-54-5 MFCD00007721

化学结构图

SMILES: NC1CCCCC1N

化学属性

Mol. Formula	C6H8N2
Mol. Weight	108
Boiling Point	256-258
Melting Point	100-102
Density	1.03
Flash Point	110°C
Solubility	Soluble in alcohol, chloroform, ether, slightly soluble in water
TSCA	Yes
Vapor Density	3.7 (vs air)
Vapor Pressure	0.01 mmHg ( 25 °C)
Stability	对光敏感,对空气敏感
Appearance	tablet

别名和识别编码

Chemical Name	1,2-Phenylenediamine
CAS Number	95-54-5
Synonym	1,2-Phenylenediamine {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {TRC} o-Phenylenediamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Diaminobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Diaminobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Diaminobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Diaminobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} o-Diaminobenzene
PubChem Substance ID	7243
EC Number	202-430-6
Beilstein Registry Number	606074
MDL Number	MFCD00007721
Reaxys-RN	606074
Merck Number	7284
Chemical Name Translation	1,2-苯二胺
Wiswesser Line Notation	ZR BZ
LabNetwork Molecule ID	LN00194690
InChI	InChI=1S/C6H8N2/c7-5-3-1-2-4-6(5)8/h1-4H,7-8H2
Canonical SMILES	NC1=CC=CC=C1N

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分类

{SA} Alphabetical, Biochemicals and Reagents, Carbohydrate Labels, Carbohydrate Labels for Chromatography, Detection, Fluorescent Enzyme Substrates, Fluorescent Enzyme Substrates for Immunoassays, Fluorescent Enzyme Substrates for Microscopy, Fluorescent Labels, Fluorescent Probes, Labels, Particles and Stains, Functional Group Reactive Labels,
{SNA} Amines,

产品应用

检定镍和铌，分光光度法测定硒。钒的检定。从氮的氧化物和双氧水中分离臭氧。用以区别亚硝酸、过氧化氢与臭氧。酸碱滴定的荧光指示剂（pH≦3.1呈绿色荧光，pH≧4.4荧光消失）螯合沉淀剂。还原剂。
邻苯二胺是一种过氧化物酶底物，适用于ELISA酶联反应。该底物产生一种可溶性的终端产品，为橙褐色，可以被分光光度计在450nm读取。该OPD 反应可以用3 N HCl 或 3 M H2SO4 终止并在 492 nm处读取。

安全信息

GHS Symbol

WGK Germany3

Hazard Codes T,N

Hazard statements

H302+H312
H312+H332
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H301 Toxic if swallowed 吞食有毒
H351 Suspected of causing cancer 怀疑致癌
H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H319 Causes serious eye irritation 严重刺激眼睛
H332 Harmful if inhaled 吸入有害
H312 Harmful in contact with skin 皮肤接触有害
H371 May cause damage to organs 可能导致器官损伤

Precautionary statements

P337+P313
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P308+P313
P304+P340+P310
P501 Dispose of contents/container to..… 处理内容物/容器.....
P301+P312+P330
P302+P350
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P201 Obtain special instructions before use. 使用前获取专门指示。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P273 Avoid release to the environment. 避免释放到环境中。
P305+P351+P338+P337+P313
P308+P311
P405 Store locked up. 上锁保管。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。

Signal word

RTECSSS7875000

UN Number

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

Safety Statements

S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R36 Irritating to eyes 刺激眼睛
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
R50/53
R25 Toxic if swallowed 吞咽有毒
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Packing GroupIII

Hazard Class6.1

Warnings 危化品目录(2015)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 336 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 50(6),78,1985

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTEHD6 Journal of Tox

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1873 mg/m3
TOXIC EFFECTS :
   Peripheral Ne

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
   Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
   Industrial Hygienists, Inc., 1986  Volume(issue)/page/year: 6,1214,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KJMSAH Kyushu Journal of Medical Science.  (Fukuoka, Japan)  V.6-15,
   1955-64.  Discontinued.  Volume(issue)/page/year: 13,175,1962

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 umol/plate
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floo

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 432 mg/kg/24H
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   43,249,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 gm/L
REFERENCE :
   JIMMBG Journal of Immunological Methods.  (Elsevier Science Pub. Co., Inc.,
   52 Vanderbilt Ave., New York, NY 10017)  V.1-    1971-
   Volume(issue)/page/year: 36,55,1980

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - guinea pig
DOSE/DURATION           : 216 mg/kg/24H
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   43,249,1980

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 140 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 192,239,1987

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 216 mg/kg/24H
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl.

Restrict 危险品

其他信息

外观性质:无色单斜晶体。
毒性:邻苯二胺有中等程度毒性，常因吸入粉尘或经皮肤吸收而引起中毒 (后者现象居多)。对皮肤有强刺激作用，可引起严重的急性发疹性湿疹，并有痂皮；吸入粉尘可引起鼻炎、支气管炎，经常发烧，引起特有的哮喘以及由于气管炎症而引起迷走神经紧张等症状。间苯二胺可致高铁血红蛋白改变，而对苯二胺则会引起支气管哮喘、过敏性皮炎。以上信息由Chemicalbook彤彤编辑整理。
用途六:该品是染料、农药、助剂、感光材料等的中间体。其本身为染料皮毛黄棕M。用于制造聚酰胺、聚氨酯、杀菌剂多菌灵和托布津、还原大红GG、匀染剂、防老剂MB，还用于制备显影剂、表面活性剂等。
方法二:以邻硝基苯胺为原料，用硫化钠还原法或催化加氢还原法制得邻苯二胺。在还原锅内加入21%的硫化钠溶液和邻硝基苯胺，升温至90℃，密闭升温至105-110℃，压力自升为0.1-0.2MPa，搅拌还原5h，降温至40℃以下，过滤。将滤饼加热熔化，减压蒸馏，收集140-210℃（7.89kPa）馏分即为邻苯二胺，收率70-80%。加氢过程在高压釜中进行，反应温度为95-105℃，压力为2MPa左右，在镍催化剂作用下通氢反应约1h，至氢压不下降为止。邻苯二胺的收率在97%以上。
上游原料:三乙
下游产品:甲基硫菌灵 --> 2-巯基苯并咪唑 --> 奥沙米特 --> 氰氨基甲酸甲酯 --> 奥美拉唑 --> 4-溴-2,1,3-苯并噻二唑 --> 2-甲基喹喔啉 --> 2-喹喔啉硫醇 --> 喹喔啉 --> 苯并咪唑-2-甲酰氯盐酸盐 --> 3-甲基-2-羟基喹喔啉 --> 4-喹喔啉基-2-苯酚 --> 2-(2-吡啶)-苯并咪唑 --> 2-喹喔啉羧酸乙酯 --> 3-甲基-2-氯-喹喔啉 --> 邻氨基乙酰苯胺 --> 喹硫磷 --> 奥吩达唑 --> 还原红 14 --> (1-甲基-1H-苯并眯唑-2-基)甲胺 --> 2,3-吡嗪二酸酐 --> 麦穗灵 --> 2-喹喔啉羧酸 --> 1H-苯并咪唑-2-硫醇 --> 1H-苯并咪唑-2-甲酸 --> 1,10-菲罗啉 --> 喹喔啉-2,3-二羧酸 --> 分散剂 BZS --> 2,3-二氨基酚嗪 --> 2-氨基-3-羟基吩嗪 --> 2-(二氯甲基)
用途四:用作农药、医药、染料中间体
检测方法:GC
方法一:其制备方法有以下几种。邻硝基苯胺与硫化钠还原法用邻硝基苯胺与硫化钠溶液在压力98～196kPa、反应温度105～110℃情况下反应，亦可在反应温度120～130℃和常压下进行，反应时间3～4h，得到邻苯二胺。邻硝基苯胺加氢还原法以邻硝基苯胺为原料，兰尼镍为催化剂，在高压釜中控制温度95～105℃，连续通氢气至压力不降为止，在1.960 MPa压力下搅拌反应得到产品。上述两个制备方法中，用硫化钠还原法得到产品的纯度较高，工艺路线比较成熟，国内有较多的工厂用此法生产邻苯二胺。但该方法劳动保护条件较差，废水较多。而催化加氢法在工艺上还存在些问题，工业化有待进一步改进。此外还有邻二氯苯氨解法，国内有较多单位曾进行研究，但尚未工业化。
灭火剂:雾状水、二氧化碳、砂土
1,2-苯二胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80099825 邻苯二胺 50g 18元 2011/08/23 80099826 邻苯二胺 100g 35元 2011/04/16 P0968 1,2-苯二胺 1,2-Phenylenediamine 25G 551元
防护措施:有毒。可经皮肤吸收或吸入粉尘而引起中毒。经皮肤吸收引起中毒的现象居多。它对皮肤的反应各不相同，急性湿疹可扩散至背部、面部和腹部，并且有类似丹毒的痂皮。其粉尘可以引起鼻炎、支气管炎、经常发烧、特有的喘息以及由于支气管炎症而引起迷走神经的紧张等症状。家兔经口MLD300mg/kg。防护方法与“苯胺”相同。
化学性质:邻苯二胺具有较活泼的化学性质，可与酸、醛、酮等化合物缩合，得到杂环化合物，还可发生氧化、缩聚、取代、重氮化等反应。图2为邻苯二胺氧化反应。图3为邻苯二胺缩合反应。
储运特性:库房通风低温干燥; 与食品原料分开储运
见光或露置