CAS 78-98-8 MFCD00006960-Methylglyoxal 丙酮醛 TAO{mole}

Methylglyoxal 丙酮醛

CAS 78-98-8 MFCD00006960

化学结构图

SMILES: CC(=O)C=O

化学属性

Mol. Formula	C3H4O2
Mol. Weight	72.06
Density	1.17
Refractive index	n20/D 1.41
TSCA	Yes
Melting Point	25 °C
Boiling Point	72 °C at 760 mmHg
Solubility	>=10 G/100 ML AT 17 ºC
Stability	对湿度敏感
Appearance	具有刺激气味的黄色粘稠状液体。
pH	:A

别名和识别编码

Chemical Name	Methylglyoxal
Synonym	Pyruvic aldehyde {LY} Pyruvic aldehyde {} {LY} Pyruvic aldehyde {} {} {LY} Pyruvic aldehyde {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyruvic aldehyde {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number	78-98-8
EC Number	201-164-8
Beilstein Registry Number	906750
MDL Number	MFCD00006960
PubChem Substance ID	880
Merck Number	14,6081
Chemical Name Translation	丙酮醛
Wiswesser Line Notation	VHV1
LabNetwork Molecule ID	LN00010096
Canonical SMILES	CC(C=O)=O
InChI	InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3

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产品应用

用作医药、农药中间体及生化试剂

安全信息

Signal word

GHS Symbol

WGK Germany3

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R36 Irritating to eyes 刺激眼睛
R22 Harmful if swallowed 吞咽有害
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P234 Keep only in original container. 只保留在原来的容器中。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P312
P301+P317
P302+P352
P304+P340
P305+P351+P338
P305+P354+P338
P308+P313
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P317
P318
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P332+P317
P333+P313
P333+P317
P337+P313
P337+P317
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
P403+P233
P404 Store in a closed container. 贮存于密闭容器中。
P405 Store locked up. 上锁保管。
P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H290 May be corrosive to metals 可能腐蚀金属。
H302 Harmful if swallowed 吞食有害
H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H318 Causes serious eye damage 严重伤害眼睛
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激
H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Storage condition Solution, -20°C, 2 years {LY} Solution, -20°C, 2 years {} {LY} Solution, -20°C, 2 years {} {} {LY} Solution, -20°C, 2 years {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C, 2 years {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Solution, -20°C

Hazard Codes Xn Xn,Xi

RTECSUZ0700000

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 179 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1165 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EESADV Ecotoxicology and Environmental Safety.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1977-  Volume(issue)/page/year:
   2,369,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 252 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CKFRAY Ceskoslovenska Farmacie.  (PNS-Ustredni Expedice a Dovoz Tisku,
   Kafkova 19, 160 00 Prague 6, Czechoslovakia)  V.1-    1952-
   Volume(issue)/page/year: 15,300,1966

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 1480 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   27,1498,1967

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 2,275,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 15 mmol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1-

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - guinea pig Cells - not otherwise specified
DOSE/DURATION           : 6600 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   38,339,1982

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/y

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 300 mg/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-

其他信息

FEMA:2969
MSDS 信息:Pyruvaldehyde(78-98-8).msds
用途一:用作医药、农药中间体及生化试剂
Acros Organics:丙酮醛 Pyruvic aldehyde, 40 wt% solution in water(78-98-8)
下游产品:丙酮酸 --> 2-丙烯基-3-甲基-4-羟基-2-环戊烯-1-酮 --> 炔丙菊酯 --> 2-喹喔啉甲醛 --> 2-甲基咪唑-4-磺酸 --> 2-甲基喹喔啉 --> 吡唑硫磷 --> 2-甲基吡嗪 --> 2,4-二甲基咪唑 --> 1,1-二甲氧基丙酮
Hazard Note:Irritant
用途二:可作西咪替丁、乳酸、丙酮酸、止痛药、抗癌、抗高血压药、脱敏剂、化妆品等原料。
MOL 文件:78-98-8.mol
Alfa Aesar:丙酮醛,35%w/waq.Soln Pyruvic aldehyde, 35% w/w aq. soln(78-98-8)
使用限量:FEMA(mg/kg)：饮料、冷饮，1.0；糖果、焙烤制品，0.03～5.0。适量为限(FDA，§172．515，2001)。
Sigma Aldrich:78-98-8(sigmaaldrich)
丙酮醛价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30161280 丙酮醛　40％ 100ml 412元 2010/06/21 175795000 丙酮醛 Pyruvic aldehyde , 40 wt% solution in water 500 GR 7198元 2010/06/21 175791000 丙酮醛 Pyruvic aldehyde , 40 wt% solution in water 6 x 100 GR 12564元
水溶性≥10 g/100 mL ( 17℃ )
毒性:GRAS(FEMA)。