CAS 77-09-8 MFCD00005913-Phenolphthalein 酚酞 TAO{mole}

Phenolphthalein 酚酞

CAS 77-09-8 MFCD00005913

化学结构图

SMILES: O=C1OC(c2ccc(O)cc2)(c2ccc(O)cc2)c2ccccc21

化学属性

Mol. Formula	C20H14O4
Mol. Weight	318.328
Melting Point	261-263°C
TSCA	Yes
Density	1.299
Solubility	Soluble in alcohol. Slightly soluble in ether
Flash Point	11°(52°F)
Appearance	白色粉末。熔点258-262℃，相对密度1.27。溶于10份醇，溶于稀碱溶液呈深红色，微溶于醚，不溶于水，无臭，无味。
Stability	对湿度敏感
Boiling Point	82 °C(lit.)
Refractive index	n20/D 1.377(lit.)

别名和识别编码

Chemical Name	Phenolphthalein
Synonym	Phenolphthalein {LY} Phenolphthalein {} {LY} Phenolphthalein {} {} {LY} Phenolphthalein {} {} {} {LY} Phenolphthalein {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {} {}
MDL Number	MFCD00005913
CAS Number	77-09-8
PubChem Substance ID	4764
EC Number	201-004-7
Beilstein Registry Number	18(3/4)1945
Merck Number	7243
Reaxys-RN	284423
Chemical Name Translation	酚酞
InChIKey	KJFMBFZCATUALV-UHFFFAOYSA-N
Wiswesser Line Notation	T56 BVO DHJ D- D-/R DQ 2
LabNetwork Molecule ID	LN00195715
InChI	InChI=1S/C20H14O4/c21-15-9-5-13(6-10-15)20(14-7-11-16(22)12-8-14)18-4-2-1-3-17(18)19(23)24-20/h1-12,21-22H
Canonical SMILES	O=C1OC(C2=CC=C(O)C=C2)(C3=CC=C(O)C=C3)C4=C1C=CC=C4

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品牌质保精细包装现货库存一流品牌服务

产品应用

酸碱指示剂, 非水溶液滴定指示剂, 色谱分析试剂。

安全信息

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
P241+P242+P243
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P310
P303+P361+P353
P304+P340
P304+P340+P312
P305+P351+P338
P308+
P308+P313
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P337+P313
P370+P378
P403+P233
P403+P235
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H226 Flammable liquid and vapour 易燃液体和蒸气
H301+H311+H331
H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
H350 May cause cancer 可能致癌
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H370 Causes damage to organs 导致器官损伤

WGK Germany3

Signal word Danger

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter dust mask type N95 (US), Eyeshields, Gloves

RTECSSM8380000

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S20 When using do not eat or drink 使用时，不得进食，饮水；
S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S7/9 Keep container tightly closed and in a well-ventilated place 保持容器严格密闭，置于通风良好的场所；
S7 Keep container tightly closed 保存在严格密闭容器中；
S33 Take precautionary measures against static discharges 对静电采取预防措施；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S24 Avoid contact with skin 避免皮肤接触；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Packing GroupIII

UN Number 1993 UN1987 UN1986 1170 UN 1219 3/PG 2 UN 1993

Risk Statements

R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
R62 Possible risk of impaired fertility 有削弱生殖能力的危险
R45 May cause cancer 可能致癌
R10 Flammable 易燃
R22 Harmful if swallowed 吞咽有害
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

Hazard Codes F F,T Xn Xi,F,Xn T Xn,T,F

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light Flammables area {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, pr

Hazard Class3

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 281 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - tumors
   Skin and Appendages - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-465,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 364 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
   Endocrine - adrenal cortex tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-465,1996

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,25,1953

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,30,1953

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 29 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - gastritis
   Gastrointestinal - nausea or vomiting
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 60,491,1984

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1680 mg/kg/14D (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 341,151,1995

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 341,151,1995

其他信息

灭火剂:干粉、干砂、二氧化碳、泡沫
上游原料:磷酸 --> 硅藻土 --> 丙烯 --> 2-氨基-3-氯苯甲酸 --> 丙酯 --> 循环压缩机
图谱信息:酚酞(77-09-8)红外图谱(IR1) 酚酞(77-09-8)红外图谱(IR2) 酚酞(77-09-8)核磁图( 13 CNMR) 酚酞(77-09-8)Raman光谱酚酞(77-09-8)质谱(MS) 酚酞(77-09-8)核磁图( 1 HNMR)
使用限量:FEMA(mg/kg)：软饮料25，糖果10～75，焙烤食品75。
MOL 文件:67-63-0.mol
所属类别二:食品添加剂: 食品加工助剂: 溶剂和助溶剂
FEMA:2929
防护措施:易燃低毒物质。蒸气的毒性为乙醇的二倍，内服时的毒性则相反。高浓度蒸气具有明显麻醉作用，对眼、呼吸道的粘膜有刺激作用，能损伤视网膜及视神经。大鼠经口LD50为5.47g/kg。空气中最高容许浓度980mg/m3。操作人员应戴防毒面具。浓度高时应戴气密式防护眼镜。密闭设备及管路；实行局部或全面通风。
蒸气密度:2.1 (vs air)
用途三:异丙醇是农药生产的重要中间体，可以生产杀菌剂稻瘟灵、异稻瘟净等，杀虫杀螨剂胺丙畏、水胺硫磷
危害:经常暴露于异丙醇的人存在一定的中毒风险，试验分析员，打字员，画家，木匠和内务人员，以及使用异丙醇的不同行业工人属于职业暴露人群。口服，吸入，皮肤和眼睛是受其影响的四个最基本途径。偶然摄入异丙醇二十毫升以上可能导致毒性发作。周围环境超过500ppm浓度水平，应该使用自给式呼吸器。当浓度达到12000，就会及其危险，甚至危及健康和生命。尽管通过皮肤吸收的很少，但是长期接触也会造成不良反应，过度暴露可以导致眼，鼻，喉不适。它也可能会导致中枢神经系统衰弱。严重情况下，会引起混乱，精神协调，循环系统和呼吸系统问题。若发现吸入异丙醇之病患，应先移除污染源或将患者移到新鲜空气处。倘若患者停止呼吸应立即施予人工呼吸后再就医。若发现误食异丙醇者，应先给病患服用大量的水后再送医治疗。异丙醇排放物还会污染环境，异丙醇是一种光化学氧化剂，它与存在地面附近的其它痕量气体一样，受阳光照射会形成臭氧，从而导致所谓“夏季烟雾”现象，光化学烟雾会刺激人的眼睛和呼吸系统，危害人们的身体健康和植物的生长，因此，异丙醇是一种对环境、
不同用途的市场需求分析:欧洲溶剂工业集团（ESIG）称，2001年欧洲中间体需求占到异丙醇消费量的32%，有14%的异丙醇用作防冰剂，13%用于油漆和
酚酞价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 10015318 酚;石炭酸; 苯酚 500g 26元 2011/08/23 1001
蒸气压:33 mm Hg ( 20 °C)
作用与用途:异丙醇是重要的化工产品和原料。主要用于制药、化妆品、塑料、香料、涂料及电子工业上用作脱水剂及清洗剂。测定钡、钙、镁、镍、钾、钠和锶等的试剂。色谱分析参比物质。在电路板制造业，它被用作清洗剂，以及制作PCB孔导电。很多人发现它不但可以很好的清洗主板，而且往往可以取得最佳的效果。此外，它还用于其他电子设备，包括清洁光盘盒，软盘驱动器，磁带，以及CD或DVD播放机光盘驱动器的激光头等。异丙醇还可以作为溶剂用于柔印，平版印刷，凹版印刷，并作为设备清洁剂。在油墨中也经常包含这种成分。它还是实验室稀释和提取的重要溶剂。此外，异丙醇还用作汽油添加剂和燃料管道的除冰剂。在制药和化妆品工业，异丙醇用于制造生产擦洗液，手和身体乳液，防腐剂，以及制药发红剂。它也用于油漆，稀释剂，涂料，清洁剂和抛光，以及表面杀菌，医院消毒，食品加工厂等。在许多工业和消费产品中，异丙醇用作低成本溶剂，也用作萃取剂,在许多情况下可代替乙醇使用。异丙醇还用作油品
方法二:由硫酸吸收丙烯，再水解后精馏而得纯品。
用途二:用作实验用化学试剂及色谱分析试剂
刺激数据:眼睛- 兔子 100 毫克/ 24小时中度
凝固点:-89.5℃
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