CAS 573-58-0 MFCD00004028-Congo red 刚果红 TAO{mole}

Congo red 刚果红

CAS 573-58-0 MFCD00004028

化学结构图

SMILES: Nc1c(/N=N/c2ccc(-c3ccc(/N=N/c4cc(S(=O)(=O)[O-])c5ccccc5c4N)cc3)cc2)cc(S(=O)(=O)[O-])c2ccccc12.[Na+].[Na+]

化学属性

Mol. Formula	C32H22N6Na2O6S2
Mol. Weight	697
Density	0.995 g/mL at 25 °C
Melting Point	>360
TSCA	Yes
Solubility	可溶
Stability	对湿度敏感
Appearance	棕红色粉状物，易溶于热水，溶于10份冷水，溶液呈黄红色；溶于乙醇呈橙色；极微溶于丙酮，几乎不溶于醚。溶于乙醇呈橙色，微溶于丙酮。在浓硫酸中呈深蓝色，稀释后呈浅蓝色有蓝针对沉淀。其水溶液加浓盐酸生成戏光蓝色沉淀；加乙酸生成呈蓝光紫色转为较红的蓝色沉淀。在浓烧碱中不溶解。对酸、盐敏感，即使从空气中吸收二氧化碳，也会使色泽变蓝暗，但用稀纯碱液处理可恢复原来色泽。

别名和识别编码

Chemical Name	Congo red
CAS Number	573-58-0
EC Number	209-358-4
Beilstein Registry Number	3894858
MDL Number	MFCD00004028
Synonym	3,3'-[(1,1'-BIPHENYL)-4,4'-DIYLBIS(AZO)]BIS(4-AMINO-1-NAPHTHALENESULFONIC ACID) 2NA 3,3'-[[1,1'-联苯]-4,4'-基双(偶氮)]双(4- 4'-基双(偶氮)]双(4-氨基萘-1-磺酸)二钠 4-二[(偶氮-2)-1-氨基萘-4-磺酸钠 Atlantic C Benzo Congo Red C.I. 22120; Disodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis(4-aminonaphthalene-1-sulphonate) C.I.直接红28 CONGO RED CONGO RED 4B Congo Red Congo Red L Congo Red M Congo Red RS Congo Red W DIRECT RED 28 Direct Red 28 Natrium-salz der d Red, Congo {} {} {} {} {} {} {} {} {} {} {} {} {} {} { 二苯基-4,4′-二［(偶氮-2-)-1-氨基萘-4-磺酸钠］剛果紅棉红 B 直接朱红直接红 28
PubChem Substance ID	11313
Merck Number	2498
Chemical Name Translation	刚果红
Reaxys-RN	6765909
Wiswesser Line Notation	L66J BZ ESWQ CNUNR DR DNUN- CL66J BZ ESWQ &-NA- 2
LabNetwork Molecule ID	LN00194917
InChI	InChI=1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2

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产品应用

酸碱指示剂[pH3.0(蓝紫)-5.0(红)]，吸附指示剂，沉淀蛋白质，检测胃液中的游离盐酸、胚胎切片、植物粘蛋白、纤维素、弹性组织等染色，测定硼酸、氰化物和盐酸等。

安全信息

Signal word Danger

GHS Symbol

WGK Germany3

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R36 Irritating to eyes 刺激眼睛
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R45 May cause cancer 可能致癌
R63 Possible risk of harm to the unborn child 可能危害未出生婴儿

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P305+P351+P338
P308+P313
P318
P337+P313
P337+P317
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H319 Causes serious eye irritation 严重刺激眼睛
H350 May cause cancer 可能致癌
H351 Suspected of causing cancer 怀疑致癌
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RTECSQK1400000

Hazard Codes T T,Xi

Packing GroupII

UN Number 2811

Storage condition 密封保存。 Flammables area

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TSCAT* Office of Toxic Substances Report.  (U.S. Environmental Protection
   Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
   Volume(issue)/page/year: OTS 215154

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 120 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Blood - change in clotting factors
REFERENCE :
   AJMSA9 American Journal of the Medical Sciences.  (Slack Inc., 6900 Grove
   Rd., Thorofare, NJ 08086) New series: V.1-    1841- Volume(issue)/page/year:
   198,73,1939

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOIMA3 Journal of Immunology.  (Williams & Wilkins Co., 428 E. Preston St.,
   Baltimore, MD 21202) V.1-    1916-  Volume(issue)/page/year: 68,53,1952

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 143 mg/kg
TOXIC EFFECTS :
   Vascular - other changes
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,185,1969

TYPE OF TEST            : LCLo - Lowest published lethal con

TYPE OF TEST            : LDLo - Lowes

TYPE OF TEST            : DNA adduct
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 192 umol/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 5,231,1984

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - hamster Liver
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 136,255,1984

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 110 mg/L
REFERENCE :
   NNBYA7 Nature (London), New Biology.  (Basingstoke, Hants., UK)  V.229-246,
   1971-73.  For publisher information, see NATUAS.  Volume(issue)/page/year:
   232,143,1971

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 33 ug/plate
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 3,21,1982

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 136,255,1984

TYPE OF TEST            : Body fluid assay
TEST SYSTEM             : Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION           : 300 mg/kg
REFERENCE :
   IAEHDW International Archives of Occupational and Environmen

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 140 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 117,176,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1500 mg/kg
SEX/DURATION            : female 8-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - physical
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   4,403,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 5 gm/kg
SEX/DURATION            : female 8-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - physical
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   4,403,1984

TYPE OF TEST            : TDLo - Low

其他信息

下游产品:2-吡啶甲酸 --> 三(2-氨基乙基)胺 --> 猪去氧胆酸 --> 亚油酸乙酯 --> 氟氢化铵 --> 8-氮鸟嘌呤 --> N-CBZ-L-丙氨酸 --> 硝基丙二酸二乙酯 --> 2-甲基丙氨酸
Acros Organics:直接红/刚果红 Congo Red, Indicator grade(573-58-0)
溶于水呈黄红色，溶于水呈黄红色，溶于乙醇呈橙色，极微溶于丙酮，几乎不溶于乙醚。最大吸收波长(pH7.3)488nm(E1cm1%) 595。半数致死量(大鼠，静脉)190mg/kg。
MOL 文件:573-58-0.mol
刚果红价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 71011181 刚果红;直接刚果红; 煮大红; 棉红; 直接朱红; 直接大红; 二苯基-4,4′-二［(偶氮2)-1-氨基萘-4-磺酸钠］ 25g 135元 2011/08/23 71011154 刚果红;直接刚果红; 煮大红; 棉红; 直接朱红; 直接大红; 二苯基-4,4′-二［(偶氮2)-1-氨基萘-4-磺
上游原料:硫酸钠 --> 硫酸化蓖麻油 --> 联苯胺 --> 对氨基萘磺酸
用途三:酸碱指示剂[pH3.0(蓝紫)-5.0(红)]，吸附指示剂，沉淀蛋白质，检测胃液中的游离盐酸、胚胎切片、植物粘蛋白、纤维素、弹性组织等染色，测定硼酸、氰化物和盐酸等。
图谱信息:直接红 28(573-58-0)核磁图( 1 HNMR) 直接红 28(573-58-0)红外图谱(IR1) 直接红 28(573-58-0)核磁图( 13 CNMR) 直接红 28(573-58-0)红外图谱(
人工染料:即苯胺染料或煤焦油染料，种类很多，应用极广。它的缺点是经日光照射容易褪色，苯胺蓝、亮绿、甲基绿等更易褪色。在制片中注意掌握酸碱度，并避免日光直射，也能经几年不褪色。刚果红(英文Congo red)是酸性染料，呈枣红色粉末状，能溶于水和酒精，遇酸呈蓝色。能作染
方法一:由联欢苯胺重氮化后，与1，4-氨基萘磺酸钠进行偶合，而后经盐析、过滤及干燥而制得。具体操作为：取48.4g联苯胺溶于300ml盐酸（含浓盐酸20ml）中，加冰冷至5℃以下，加30ml浓盐酸后，加入由14.4g亚硝酸钠配成的10%的水溶液。重氮化结束后，将重氮盐溶液慢慢加入150g对氨基萘磺酸钠和少量水配成的溶液中，放置半小时后，在充分搅拌下慢慢加入35g碳酸钠，使溶液呈碱性，加热至约80℃后，冷却，过滤，用饱和盐水洗涤，干燥即得成品。工业制备原料消耗（kg/t）联苯胺（100%） 200氨基萘磺酸钠（100%） 520亚硝酸钠（工业） 160盐酸（31%） 330纯碱（工业） 340精盐 2500太古油 9乙醇 60乙酸钠 35元明粉 50
用途二:曾广泛用于棉、粘胶的染色，因其遇酸极易转变为蓝色，以及无适当处理方法使之提高其湿处理牢度，故自不溶性偶氮染料和直接耐酸大红4BS问世以来，该品在染色中的使用量逐减减少，但在造纸工业中用量颇大。还可作为酸碱指标剂，即刚果红试纸，pH3.0（蓝紫）-5.0（红）。另外还用于生物染色，分析试剂。
人工染料:即苯胺染料或煤焦油染料，种类很多，应用极广。它的缺点是经日光照射容易褪色，苯胺蓝、亮绿、甲基绿等更易褪色。在制片中注意掌握酸碱度，并避免日光直射，也能经几年不褪色。刚果红(英文Congo red)是酸性染料，呈枣红色粉末状，能溶于水和酒精，遇酸呈蓝色。能作染料，也用作指示剂。在植物制片中常作为苏木精或其他细胞染料的衬垫剂。用来染细胞质时，能把胶制或纤维素染成红色。在动物组织制片中用来染神经轴、弹性纤维、胚胎材料等。另外刚果红可以跟苏木静作二重染色，也可用作类淀粉染色，由于它能溶于水和酒精，所以洗涤和脱水处理要迅速。
用途一:主要用于棉、麻、丝等纺织和纸制品的染色，也可用作指示剂