CAS 493-52-7 MFCD00002425-Methyl red 甲基红 TAO{mole}

Methyl red 甲基红

CAS 493-52-7 MFCD00002425

化学结构图

SMILES: CN(C)c1ccc(/N=N/c2ccccc2C(=O)O)cc1

化学属性

Mol. Formula	C15H15N3O2
Mol. Weight	269.30
Density	0.989
Melting Point	179-182 °C
Solubility	Practically insoluble in water. Soluble in alcohol, acetic acid
TSCA	Yes
Stability	对湿度敏感
Boiling Point	412.44 °C at 760 mmHg
Flash Point	52 °F
Refractive index	n20/D 1.329(lit.)

别名和识别编码

Chemical Name	Methyl red
MDL Number	MFCD00002425
CAS Number	493-52-7
EC Number	207-776-1
Beilstein Registry Number	16(3)367
Synonym	Methyl red {LY} Methyl red {} {LY} Methyl red {} {} {LY} Methyl red {} {} {} {LY} Methyl red {} {} {} {} {LY} Methyl red {} {} {} {} {} {LY} Methyl red {} {} {} {} {} {} {LY} Methyl red {} {} {} {} {} {} {} {LY} Methyl red {} {} {} {} {} {} {} {} {LY} Methyl red {} {} {} {} {} {} {} {} {} {LY} Methyl red {} {} {} {} {} {} {} {} {} {} {LY} Methyl red {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl red {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl red {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl red {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl red {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl red {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl red {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl red
Merck Number	6119
PubChem Substance ID	87572180
Reaxys-RN	750102
Chemical Name Translation	甲基红
Wiswesser Line Notation	QVR BNUNR DN1&1
InChI	InChI=1S/C15H15N3O2/c1-18(2)12-9-7-11(8-10-12)16-17-14-6-4-3-5-13(14)15(19)20/h3-10H,1-2H3,(H,19,20)
Canonical SMILES	O=C(C1=C(/N=N/C2=CC=C(N(C)C)C=C2)C=CC=C1)O

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产品应用

原生动物活体染色，酸碱指示剂 (pH 4.4 to 6.2) ，临床血清蛋白生化检验。pH变色范围4.4(红)-6.2(黄)。滴定氨、弱有机碱和生物碱，但不适用于除草酸和苦味酸以外的有机酸。可与溴甲酚绿和亚甲基蓝组成混合指示剂以缩短变色域和提高变色的敏锐性。沉淀滴定的吸附指示剂，如用硝酸钍滴定氟离子。检定游离氯、亚氯酸盐等氧化剂。

安全信息

Signal word

GHS Symbol

WGK Germany2

Safety Statements

S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S7 Keep container tightly closed 保存在严格密闭容器中；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S24 Avoid contact with skin 避免皮肤接触；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R11 Highly flammable 非常易燃
R10 Flammable 易燃
R68/20/21/22
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R36 Irritating to eyes 刺激眼睛
R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
R51/53
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P233 Keep container tightly closed. ?保持容器密闭。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P241+P242+P243
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P303+P361+P353
P304+P340
P304+P340+P312
P305+P351+P338
P305+P351+P338+P337+P313
P308+P313
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

RTECSDG8960000

Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Hazard Codes N Xn

UN Number 1170 UN 1170 3/PG 2

Hazard statements

H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H371 May cause damage to organs 可能导致器官损伤

Packing GroupII

Storage condition RT, protect from light {LY} RT, protect from light Store at RT. {} {LY} RT, protect from light {} {} {LY} RT, protect from light {} {} {} {LY} RT, protect from light {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from

Hazard Class3

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 12 gm/kg/57W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   9,310,1955

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 2 mg/disc
REFERENCE :
   TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho.  Annual Report of Tokyo
   Metropolitan Research Laboratory of Public Health.  (Tokyo-toritsu Eisei
   Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
      1949/50-  Volume(issue)/page/year: 27,153,1976

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 56,249,1978

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 10 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   46,1654,1986

其他信息

刺激数据:眼睛- 兔子 100 毫克/ 24小时中等; 皮肤- 兔子 20 毫克/ 24小时中等
几乎不溶于水，溶于乙醇。乙醇溶液经长时间保存后，可因羧基起酯化作用而使灵敏度显著降低。
蒸气压:410 mm Hg ( 50 °C)
用途五:基本有机原料之一。主要用于
下游产品:2-氨基-4-甲氧基吡啶 --> 1,5-萘二磺酸二钠二水合物 --> 3,5-二甲氧基苄醇 --> 3-氨基苯甲酸甲酯 --> 3-(甲基丙烯酰氧)丙基三甲氧基硅烷 --> 二甲氨基苯乙酮 --> 5-甲基-2-己醇 --> 3-四氢呋喃甲酸 --> 2-喹啉甲胺 --> 3-吡啶甲酰肼 --> 4,6-二羟基-5-溴嘧啶 --> 咪唑-2-甲醇 --> 3-(苄基氨基)丙酸乙酯 --> 二十三酸甲酯 --> 5-溴-2-氯-4-甲氧基嘧啶 --> 4-氨基丁酸甲酯盐酸盐 --> N,N'-二苯亚甲基联苯胺 --> 4-羟基-5-氟嘧啶 --> 三甘醇单甲醚 --> 一氯频呐酮 --> 二丙二醇甲醚 --> 3-甲氧基羰基吡啶-2-羧酸 --> 3-羧酸-4-羧酸甲酯吡啶 --> 3,4-二甲基苯甲酸甲酯 --> 4-溴苄醇 --> 吗啉-4-甲脒 --> 2-噻吩甲酰肼 --> 戊二酸单乙酯 --> 硬酯酸甲酯C18 --> 2-甲氧基-3-异丁基吡嗪 --> 二苯基二甲氧基硅烷 --> 甲基化牛血清白蛋白,METHYL ESTER OF BOVINE ALBUMIN --> 2-(二甲氧甲基)-1-庚烯基苯 --> 3-氯丙基三甲氧基硅烷 --> 3-(2,3-环氧丙氧)丙基三甲氧基硅烷 --> 乙烯基三甲氧基硅烷 --> 甲醇钾
用途四:萃取溶剂。其成品最高允许残留量：香辛料油树脂50mg/kg，酒花抽提物2.2mg/kg。 GB 2760-96列为食品加工助剂。
检测方法:GC
毒理学简介:人(男性)经口LDLo: 6422mg/kg; TDLo: 3429mg/kg。女性经口TDLo:4mg/kg 。另有报道，人类经口LDLo：428mg/kg，143mg/kg不等；吸入TCLo: 86000mg/m3 ，300ppm不等。大鼠经口LD50: 5628mg/kg; 吸入LC50: 64000ppm/4H 。小鼠经口LD50: 7300mg/kg;吸入 LCLo: 50 gm/m3/2H。兔经皮LD50: 15800 mg/kg。甲醇吸收至体内后,可迅速分布在机体各组织内,其中,以脑脊液、血、胆汁和尿中的含量最高, 眼房水和玻璃体液中的含量也较高, 骨髓和脂肪组织中最低。甲醇在肝内代谢, 经醇脱氢酶作用氧化成甲醛, 进而氧化成甲酸。本品在体内氧化缓慢，仅为乙醇的 1/7 ,排泄也慢,有明显蓄积作用。未被氧化的甲醇经呼吸道和肾脏排出体外,部分经胃肠道缓慢排出。推测人吸入空气中甲醇浓度 39.3～65.5g/m^3, 30～60 分钟,可致中毒。人口服5～10ml, 可致严重中毒; 一次口服 15ml , 或 2天内分次口服累计达 124～164ml,可致失明。有报告,一次口服 30ml 可致死。甲醇主要作用于神经系统,具有明显的麻醉作用,可引起脑水肿。甲醇的麻醉浓度与LC较接近,故危险性较大。对视神经和视网膜有特殊的选择作用，易引起视神经萎缩，导致双目失明。甲醇蒸气对呼吸道粘膜有强烈刺激作用。甲醇的毒性与其代谢产物甲醛和甲酸的蓄积有关。以前认为毒性作用主要为甲醛所致, 甲醛能抑制视网膜的氧化磷酸化过程,使膜内不能合成ATP,细胞发生变性,最后引起视神经萎缩。近年研究表明,甲醛很快代谢成甲酸,急性中毒引起的代谢性酸中毒和眼部损害，主要与甲酸含量相关。甲醇在体内抑制某些氧化酶系统，抑制糖的需氧分解，造成乳酸和其他有机酸积聚以及甲酸累积,而引起酸中毒。一般认为,甲醇的毒性是由其本身及其代谢产物所致的。DLH: +6000 ppm [R28]
上游原料:氢氧化钠 --> 氢 --> 二氧化碳 --> 氧 --> 一氧化碳 --> 甲基叔丁基醚 --> 乳酸 --> 冶金焦 --> 重油 --> 甲烷 --> 柴油机燃料油 --> 渣油 --> L-乳酸
Acros Organics:甲醇 Methanol, AcroSeal?, Extra Dry over Molecular Sieve, 99.8%(67-56-1)
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