CAS 860-22-0 MFCD00005723-Indigo carmine 靛蓝二磺酸钠 TAO{mole}

Indigo carmine 靛蓝二磺酸钠

CAS 860-22-0 MFCD00005723

化学结构图

SMILES: O=C1C(c2[nH]c3ccc(S(=O)(=O)[O-])cc3c2O)=Nc2ccc(S(=O)(=O)[O-])cc21.[Na+].[Na+]

化学属性

Mol. Formula	C16H8N2Na2O8S2
Mol. Weight	466.35
Density	1.01
Refractive index	n20/D 1.335
Melting Point	>300°
TSCA	Yes
Solubility	Soluble in water (10 g/l at 25 °C), glycol, and ethanol (3 mg/ml). Insoluble in benzene, and chloroform.
Stability	对光敏感
Appearance	深绿色粉末或颗粒。溶于水，微溶于乙醇。

别名和识别编码

Chemical Name	Indigo carmine
MDL Number	MFCD00005723
CAS Number	860-22-0
Synonym	(delta-2,2'-biindole)-3,3'-dione 2(1,3-二氢-3-氧代-5-磺基-2H-吲哚 2-(1,3-Dihydro-3-oxo-5-sulpho-2H-indol-2-ylidene)-3- oxoindoline-5-sulphonic acid 5,5'-INDIGODISULFONIC 5,5-INDIGO DISULFONIC ACID 5,5ˊ-靛蓝二磺酸二钠盐 A.F. Blue No. 2 Amacid Brilliant Blue BLUE ACID 74 Bucacid indigotine B C.I. 75781 C.I. Acid Blue 74 C.I. Food Blue 1, disodium salt Canacert Indigo Carmine Carmine, Indigo D and C Blue NO. 6 Disodium salt of 1-indigotin-S,S'-disulphonic acid Edicol Supra Blue X FD AND C BLUE 2 FD and C Blue No. 2 FDC BLUE NO 2 FOOD BLUE NO 2 Hexacert Blue No. 2 INDIGO-5,5'-DISULFONIC ACID DISODIUM S Ind Indigo Blue Indigo Blue, Soluble
Beilstein Registry Number	4103904
PubChem Substance ID	2723854
EC Number	212-728-8
Merck Number	4944
Chemical Name Translation	靛蓝二磺酸钠
Reaxys-RN	905434
Wiswesser Line Notation	T56 BMYVJ GSWO CU- CT56 BMYVJ GSWO &-NA- 2
LabNetwork Molecule ID	LN00196508
InChIKey	KHLVKKOJDHCJMG-QDBORUFSSA-L
InChI	InChI=1S/C16H10N2O8S2.2Na/c19-15-9-5-7(27(21,22)23)1-3-11(9)17-13(15)14-16(20)10-6-8(28(24,25)26)2-4-12(10)18-14;;/h1-6,17,19H,(H,21,22,23)(H,24,25,26);;/q;2*+1/p-2
Canonical SMILES	O=S(C1=CC2=C(N/C(C2=O)=C3NC4=C(C=C(S(=O)(O[Na])=O)C=C4)C\3=O)C=C1)(O[Na])=O

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

氧化还原指示剂。检验牛奶的硝酸盐和氯酸盐的试剂。生物染色剂，如尼基氏小体、细胞核的染色。肾功能的测定等。

安全信息

Hazard statements

H302 Harmful if swallowed 吞食有害
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。

GHS Symbol

WGK Germany3

Signal word Warning

RTECSDU3000000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves Eyeshields, Gloves

Hazard Codes Xn

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Risk Statements

R22 Harmful if swallowed 吞咽有害

Storage condition Light Sensitive RT, protect from light 密封保存。密封避光保存。

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312
P301+P312+P330
P301+P317
P302+P352
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P333+P317
P362+P364
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P501 Dispose of contents/container to..… 处理内容物/容器.....

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9 gm/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   8,29,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 405 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SCPHA4 Scientia Pharmaceutica.  (Oesterreichische
   Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria)
   V.1-    1930-  Volume(issue)/page/year: 47,39,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SCPHA4 Scientia Pharmaceutica.  (Oesterreichische
   Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria)
   V.1-    1930-  Volume(issue)/page/year: 47,39,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 93 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,83,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SCPHA4 Scientia Pharmaceutica.  (Oesterreichische
   Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria)
   V.1-    1930-  Volume(issue)/page/year: 47,39,1979

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 60 mg/kg/30D (Continuous)
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   30,315,1986

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 20 umol/L/5H (Continuous)
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 1,27,1979

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 12 gm/L
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   22,623,1984

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 5400 mg/kg/90D (Continuous)
REFERENCE :
   CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)  V.1- 1969- 
   Volume(issue)/page/year: 54,25,1988

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   52,33,1990

其他信息

Alfa Aesar:靛红 Indigo carmine(860-22-0)
Acros Organics:靛蓝胭脂红/靛胭脂 Indigo Carmine, high purity biological stain, for analysis(860-22-0)
{Chem
酸性蓝 74价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 71021244 靛蓝胭脂红;酸性靛蓝;可溶靛;靛卡红 25g 30.4元 2011/04/16 F0148 食品蓝2 Food Blue No. 2 25G 862元 2011/04/16 I0214 靛蓝胭
参考质量标准一:FAO/WHO，1992 总色素含量 ≥85% 135℃挥发物及氯化物和硫酸盐 ≤15% (以钠盐计；GT-19；OT-11-1； OT-44-1) 水不溶物(OT-30，试样2g) ≤0.2% 副色素(包括3，3’-二氧-2，2i双 ≤18% 二氢亚吲哚基-5，7-二磺酸二钠) 其他非色素有机物靛红-5-磺酸、5-磺基邻氨基 ≤0.5% 苯甲酸、邻氨基苯甲酸总量非磺化芳族伯胺 ≤0.01% 乙醚可萃物(OT-21) ≤0.2% 砷(以As计；OT-32) ≤3rng/kg 铅(OT-32) ≤10mg/kg 汞(OT-31) ≤1mg/kg 重金属(以Pb计；GT-16) ≤40mg/kg
参考质量标准二:FAO/WHO，1992 总色素含量 ≥80% 干燥失重(GT-19)及氯化物和硫 ≤20% 酸盐(以钠盐计；OT-11-1；OT- 44-1)总和水不
用途二:食品蓝色素。一般用于调色。因其较不稳
用途二:食品蓝色素。一般用于调色。因其较不稳定，牢度低，染色性弱，最适宜于深色调。可调制成巧克力色、绿色、赤
酸性蓝 74价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 71021244 靛蓝胭脂红;酸性靛蓝;可溶靛;靛卡红 25g 30.4元 2011/04/16 F0148 食品蓝2 Food Blue No. 2 25G 862元 2011/04/16 I0214 靛蓝胭脂红 Indigo Carmine 25G 306元
参考质量标准三:沪Q/HG 15-1204-1982(靛蓝标准) 含量/% 39.0～41.0 色调与标准品近似挥发物/% ≤5 水不溶物/% ≤0.5 乙醚萃取物/% ≤0.5 砷(As)/% ≤0.0001 重金属(以Pb计)/% ≤0.001 动物试验无急性中毒现象日本标准，1992(靛蓝铝色淀标准) 含量/%@≥10.0 盐酸和氨不溶物/%@≤0.5 水溶性氯化物和硫酸盐/%@≤2.0 干燥失重(135℃，6h)/%
{Chemi
使用限量:GB 2760-2001(g/kg)：渍制小菜0.01；果汁(味)饮料类、碳酸饮料、配制酒、糖果、糕点上彩装、染色樱桃罐头(系装饰用)、青梅、糖果包衣、威化饼干夹心，0.10；红绿丝0.20；膨化食品、油炸食品，0.05。
参考质量标准二:FAO/WHO，1992 总色素含量 ≥80% 干燥失重(GT-19)及氯化物和硫 ≤20% 酸盐(以钠盐计；OT-11-1；OT- 44-1)总和水不溶物
敏感性:Light Sensitive
Sigma Aldrich:860-22-0(sigmaaldrich)
MOL 文件:860-22-0.mol
参考质量标准二:FAO/WHO，1992 总色素含量 ≥80%
海关编码:32041200
用途四:用于食品、医药和日用化妆品的着色。食用靛蓝为食用合成色素。食用色素是用于食品着色的一类添加剂，包括合成色素和天然
用
毒性:ADI未规定(FAO/wH0，2001)。0～5(EEC，1990，暂定)。挪威、瑞士、芬兰、日本、加拿大、美国不准用。
鉴别试验:溶解性溶于水；难溶于乙醇。按OT-42方法测定。色素鉴别试验按OT-16方