CAS 127-47-9 MFCD00019413-Retinol acetate 维生素A醋酸酯 TAO{mole}

Retinol acetate 维生素A醋酸酯

CAS 127-47-9 MFCD00019413

化学结构图

SMILES: CC(=O)OC/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C

化学属性

Mol. Formula	C22H32O2
Mol. Weight	328
Melting Point	57-58 °C
TSCA	Yes
Refractive index	1.547-1.555
Solubility	可溶
Density	0.968
Appearance	solid or viscous liquid
Stability	对光敏感

别名和识别编码

Chemical Name	Retinol acetate
Synonym	All-trans-retinol acetate 乙酸维生素A 凝胶乙酸维生素A Myvak RETINYL ACETATE all-trans-Retinyl acetate Retinol acetate 维生素 A 乙酸酯乙酸维生素 A 维生素A油醋酸酯 ALL-TRANS VITAMIN A ACETATE 视黄醇乙酸酯 Davitan A 650 维生素A乙酸酯/视黄醇乙酸酯乙酸维生素A 凝胶, POWDER, 500,000 I.U./G 维生素A醋酸酯 1.0MLU/G TRANS-RETINOL ACETATE Vitamin A acetate Myvax 维生素A标准品 3,7-Dimethyl-9-(2,6,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol acetate 维生素 A 醋酸酯醋酸维生素 A
CAS Number	127-47-9
PubChem Substance ID	638034
EC Number	204-844-2
Beilstein Registry Number	1915439
MDL Number	MFCD00019413
Merck Number	14,10013
Chemical Name Translation	维生素A醋酸酯
Wiswesser Line Notation	L6UTJ A1 B1U1Y1&U2U1Y1&U2OV1 C1 C1
LabNetwork Molecule ID	LN00195136
InChI	InChI=1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+

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产品应用

维生素A 油醋酸酯能够维持人体正常代谢,能够维持细胞膜的稳定和发育、维持生殖系统的正常功能,对视觉的形成、缓和组织的角化、增强细胞的免疫能力有明显的作用.

安全信息

GHS Symbol

WGK Germany2

Hazard Codes T Xn

Hazard statements

H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H315 Causes skin irritation 会刺激皮肤
H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害

Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSVH6825000

Precautionary statements

Signal word Danger

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
R38 Irritating to skin 刺激皮肤
R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
R53 May cause long-term adverse effects in the aquatic environment 对水生环境有长期的有害作用

Storage condition 避光、防潮、隔氧2-8°C保存. Light & Air Sensitive & Hygroscopic 2-8°C

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 51800 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 74,715,1985

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 95 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Endocrine - thyroid tumors
   Skin and Appendages - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 74,715,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAADDB Journal of the American Academy of Dermatology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63141)  1979-
   Volume(issue)/page/year: 6,652,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 432 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3878202

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1 umol/L
REFERENCE :
   ONCOBS Oncology.  (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 
     1967-  Volume(issue)/page/year: 44,356,1987

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 100 umol/L
REFERENCE :
   ONCOBS Oncology.  (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 
     1967-  Volume(issue)/page/year: 44,356,1987

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Embryo
DOSE/DURATION           : 65600 ug/L
REFERENCE :
   SNSHBT Senshokutai.  Chromosome.  (Sensyokutai Gakkai, Kaokusai Kirisutokyo
   Daigaku, Mitaka, Tokyo-to, Japan)  No.1-    1946-    Adopted new numbering
   in 1976.  Volume(issue)/page/year: (20),574,1980

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 100 umol/L
REFERENCE :
   ONCOBS Oncology.  (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 
     1967-  Volume(issue)/page/year: 44,356,1987

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Mammary gland
DOSE/DURATION           : 3 umol/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 70,949,1983

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Embryo
DOSE/DURATION           : 65600 ug/L
REFERENCE :
   SNSHBT Senshokutai.  Chromosome.  (Sensyokutai Gakkai, Kaokusai Kirisutokyo
   Daigaku, Mitaka, Tokyo-to, Japan)  No.1-    1946-    Adopted new numbering
   in 1976.  Volume(issue)/page/year: (20),574,1980

TYPE OF TES

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 826 mg/kg
SEX/DURATION            : female 12-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - cytological changes (including
   somatic cell genetic material)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 18,277,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1205 mg/kg
SEX/DURATION            : female 6-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 310 mg/kg
SEX/DURATION            : female 10-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 480 mg/kg
SEX/DURATION            : female 6-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
   Reproductive - Effects on Newborn - viability

其他信息

F:1-8-10
Alfa Aesar:乙酸维生素A凝胶,powder,500,000I.U./g Vitamin A acetate in gelatin, powder, 500,000 I.U./g(127-47-9)
Acros Organics:维他命A乙酸酯 all-trans-Retinyl acetate, 1.5 million IU/g, in sunflower oil, USP/EP, stab.(127-47-9)
用途三:维生素A 油醋酸酯能够维持人体正常代谢,能够维持细胞膜的稳定和发育、维持生殖系统的正常功能,对视觉的形成、缓和组织的角化、增强细胞的免疫能力有明显的作用.
维生素 A 醋酸酯价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 K9513901 维生素A乙酸酯（-20℃） 1g 234元 2010/06/21 346321000 维生素 A 醋酸酯 all-trans-Retinyl acetate , 1.5 million IU/g, in sunflower oil, USP/EP, stab. 100 GR 1077元 2010/05/25 A16237 乙酸维生素A 凝胶, powder, 500,000 I.U./g Vitamin A acetate in gelatin, powder, 500,000 I.U./g 500g 3710元
用途一:能透皮吸收，抗角质化，刺激胶原蛋白和弹性蛋白的生长，增加表皮及真皮的厚度。增强皮肤弹性，有效消除皱纹，促进皮肤更新，保持皮肤活力。用于眼霜、保湿霜、修护霜、香波、护发素等
用途二:用于维生素A缺乏症
MSDS 信息:all-trans Vitamin A acetate(127-47-9).msds
Sigma Aldrich:127-47-9(sigmaaldrich)
建议用法:建议在油相中加入维生素 A 醋酸酯（127-47-9），添加量为0.1～1%，应加入适量抗氧剂——BHT，温度宜在60℃左右，溶解即可。
外观:淡黄色结晶；在空气中易氧化，遇光易变质。
显亮黄到淡红色的油溶液.水溶性soluble。室温放置时析出结晶,遇酸、空气、光易氧化。产品在20℃以下保存,原装瓶可保存12个月.如果原装瓶已开瓶使用,剩余部分还需继续保存,必须用隋性气体填充密封,并在20℃以下保存,否则就必须立即用完,
MOL 文件:127-47-9.mol