CAS 106-89-8 MFCD00005132-Epichlorohydrin 环氧氯丙烷 TAO{mole}

Epichlorohydrin 环氧氯丙烷

CAS 106-89-8 MFCD00005132

化学结构图

SMILES: ClCC1CO1

化学属性

Mol. Formula	C3H5ClO
Mol. Weight	93
Density	1.183
Refractive index	1.4360 to 1.4400
Boiling Point	115-117
Melting Point	-57
Flash Point	32°C(lit.)
TSCA	Yes
Autoignition Point	779 °F
Vapor Density	3.2 (vs air)
Vapor Pressure	13.8 mmHg ( 21.1 °C)
Solubility	微溶于水，可混溶于醇、醚、四氯化碳、苯。
Danger-Level	甲类

别名和识别编码

Chemical Name	Epichlorohydrin
Synonym	Oxirane, 2-(chloromethyl) 3-环氧丙烷 2-(chloromethyl)oxirane {Chem { 3-Chloro-1,2-propylene oxide (chloromethyl)ethyleneoxide alpha-Epichlorohydrin RCRA waste number U041 3-chloro-1,2-epoxypropane 1-Cloro-2,3-epossipropano dl-α-Epichlorohydrin (±)-环氧氯丙烷 ALPHA-EPICHLOROHYDRIN 1-Chloor-2,3-epoxy-propaan gamma-Chloropropylene oxide (+/-)-2-(CHLOROMETHYL)OXIRANE {Ch 1,2-Epoxy-3-chloropropane 1-CHLORO-2,3-EPOXYPROPANE {uni_hambur (±)-2-(氯甲基)环氧乙烷 1-氯-2,3-环氧丙烷氯甲代氧丙环 (Chloromethyl)-oxirane EPICHLOROHYDRIN Epicloridrina (Chloromethyl)ethylene oxide (DL)-alpha-Epichlorohydrin 1-Chloro-2,3-epoxypropane
CAS Number	106-89-8
EC Number	203-439-8
Beilstein Registry Number	79785
MDL Number	MFCD00005132
PubChem Substance ID	7835
Reaxys-RN	79785
Merck Number	3611
Chemical Name Translation	环氧氯丙烷
Wiswesser Line Notation	T3OTJ B1G
LabNetwork Molecule ID	LN00194743
InChI	InChI=1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2

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分类

{SNA} 2000/60/EC, Additional Standards, Alpha Sort, Analytical Standards, Chromatography, E, E-L, Environmental Standards, European Community: ISO, DIN and DL 152, Food and Cosmetic Component Standards, Method and Regulation Specific, Organic Pollutant Standards, Standards for Personal Care and Cosmetic Products, Volatile & Semivolatile Standards, Volatiles/ Semivolatiles, neats, prohibited substances (EU-REGULATION No 1223/2009), 分析/色谱
{SNA} 2000/60/EC, Alpha Sort, Analytical Standards, Analytical/Chromatography, Chromatography, E-L, Envi

产品应用

有机合成的原料;有机溶剂（树脂、树胶、纤维素醚等的溶剂）;也用作增塑剂、表面活性剂等

安全信息

GHS Symbol

WGK Germany3

Hazard Codes T

Hazard statements

H226 Flammable liquid and vapour 易燃液体和蒸气
H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H350 May cause cancer 可能致癌
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H301+H311+H331
H331 Toxic if inhaled 吸入中毒
H311 Toxic in contact with skin 皮肤接触中毒
H301 Toxic if swallowed 吞食有毒

Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Precautionary statements

P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P304+P340+P310
P501 Dispose of contents/container to..… 处理内容物/容器.....
P403+P233
P305+P351+P338+P310
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P301+P330+P331+P310
P303+P361+P353
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P201 Obtain special instructions before use. 使用前获取专门指示。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P301+P310
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P273 Avoid release to the environment. 避免释放到环境中。
P308+P311

Signal word

RTECSTX4900000

UN Number UN2023

Risk Statements

R45 May cause cancer 可能致癌
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R10 Flammable 易燃
R34 Causes burns 会导致灼伤
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Packing GroupII

Hazard Class6.1/3

Storage condition 易挥发，密封保存。低温(＜10℃)及避光条件下存放 Refrigerator (+4°C) + Flammables area

Warnings 危化品目录(2015)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60 gm/kg/81W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For pu

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 42525 mg/kg/81W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   NAIZAM Nara Igaku Zasshi.  Journal of the Nara Medical Association.  (Nara
   Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 32,270,1981

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5150 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
   Endocrine - tumors
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 36,325,1985

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 85050 mg/kg/81W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   NAIZAM Nara Igaku Zasshi.  Journal of the Nara Medical Association.  (Nara
   Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 32,270,1981

TYPE OF TEST            : TC - Toxic concentratio

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de
   Securite Sociale.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.7-    1946-
   Volume(issue)/page/year:

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,64,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 30,63,1948

TYPE OF TEST            : LDLo - Lowest published lethal dose
RO

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 72 gm/m3/9M
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JBMRBG Journal of Biomedical Materials Research.  (John Wiley & Sons, Inc.,
   605 Third Ave., New York, NY 10158)  V.1-

TYPE OF TEST            : LC50

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 uL/plate
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,387,1981

TYPE OF TEST            : Mutation test systems - not

{h

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 65 mmol/L
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 18,1337,1980

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   53,71,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Neurospora crassa
DOSE/DURATION           : 150 mmol/L
REFERENCE :
   STEVA8 Science of the Total Environment.  (Elsevier Science Pub. B.V., POB
   211, 1000 AE Amsterdam, Netherlands)  V.1-    1972- Volume(issue)/page/year:
   11,223,1979

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 umol/L/24H
REFERENCE :
   STEVA8 Science of the Total Environment.  (Elsevier Science Pub. B.V., POB
   211, 1000 AE Amsterdam, Netherlands)  V.1-    1972- Volume(issue)/page/year:
   11,223,1979

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 300 umol/L
REFERENCE :
   SinJF# P

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1200 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 9,87,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 288 mg/kg
SEX/DURATION            : male 23 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   JOAND3 Journal of Andrology.  (Lippincott/Harper, Journal Fulfillment Dept.,
   2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1980-
   Volume(issue)/page/year: 12,54,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 180 mg/kg
SEX/DURATION            : male 12 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 226,87,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 75 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paterna

Restrict 危险品

其他信息

有类似氯仿的气味。易挥发。不稳定。能与乙醇、乙醚、氯仿、三氯乙烯和四氯化碳等混溶，微溶于水，在20℃时，水中溶解度60g/L (10°C)。该品与水形成共沸物含水29%。不能与石油烃混溶。
中毒:环氧氯丙烷主要经呼吸道进入人体，也可经皮肤吸收。有强烈的刺激作用及致敏作用，并有轻度麻醉及原浆毒作用。高浓度液体和蒸气对眼和呼吸道粘膜有强烈刺激作用，可引起眼刺痛、流泪、咽干、咳嗽、喘息性支气管炎以及肝肾损害，严重患者可引起粘膜坏死脱落性气管炎、支气管周围炎、肺水肿和急性肾脏损害。液体污染皮肤，可出现灼伤、大疱形成及湿疹。长期吸入低浓度的蒸气，可引起四肢肌肉酸痛、腓肠肌压痛、腿软无力、全身乏力及头晕、失眠、多梦等。严重者可发生多发性神经炎。
方法一:其制备方法是以丙烯为原料，在500℃氯化生成氯丙烯，氯丙烯在25～35℃温度下，与次氯酸反应，得到2，3-二氯丙醇和1，2-二氯丙醇，然后将该混合物加入20％石灰
方法二:工业上主要用丙烯氯化法制取。丙烯和氯气进行高温氯化得到烯丙基氯，再经次氯酸化制取二氯丙醇，进而皂化制得环氧氯丙烷。原料消耗定额：丙烯（100%）640kg/t、氢氧化钠（100%）150kg/t、氯气2070kg/t、副产D-D混剂140kg/t、氢氧化钙（100%）1020kg/t。
常规方法:因氯化铁或氯化锡等能促进环氧氯丙烷自聚反应的发生，故宜贮存在干燥清洁的镀锌桶中，每桶2
防护措
有类似氯仿的气味。易挥发。不稳定。能与乙醇、乙醚、氯仿、三氯乙烯和四氯化碳等混溶，微溶于水，在20℃时，水中溶解度60g/L (10°C)。该品与水形成共沸物，含水28%。不能与石油烃混溶。
图谱信息:环氧氯丙烷(106-89-8)核磁图( 13 CNMR) 环氧氯丙烷(106-89-8)质谱(MS) 环氧氯丙烷(106-89-8)红外图谱(IR2) 环氧氯丙烷(106-89-8)核磁图( 1 HNMR) 环氧氯丙烷(106-89-8)Raman光谱环氧氯丙烷(106-89-8
TCI Shanghai:环氧氯丙烷 Epichlorohydrin,>;99.0%(GC)(106-89-8)
有类似氯仿的气味。易挥发。不稳定。能与乙醇、乙醚、氯仿、三氯乙烯
概述:环氧氯丙烷为无色油状液体，有刺激性如醚和氯仿的气味，易燃，易挥发，有毒性和麻醉性。相对密度1.1812，熔点-25.6℃
有类似氯仿的气味。易挥发。不稳定。能与乙醇、乙醚、氯仿、三氯乙烯和四氯化碳等混溶，微溶于水，在20℃时，水中溶解度60g/L (10°C)。该品与水形成共沸物含水31%。不能与石油烃混溶。
爆炸物危险特性:与空气混合可爆
有类似氯仿的气味。易挥发。不稳定。能与乙醇、乙醚、氯仿、
用途一:用作有机合成的原料，也用作溶剂、增塑剂、表面活性剂等
MSDS 信息:3-氯-1,2-环氧丙烷(106-89-8).msds
MOL 文件:106-89-8.mol
职业标准:TWA 10 毫克/ 立方米；STEL 20 毫克/立方米
可燃性危险特性:遇明火、高温、氧化剂较易燃; 燃烧产生有毒氯化物烟雾
{ALD
用途二:用作有机溶剂
类别:易燃液体
用途五:环氧氯丙烷是合成甘油中间体，也是环氧树脂、硝化甘油炸药、玻璃钢、电绝缘制品的主要原料。并用作纤维素酯、树脂和纤维素醚的混剂。也是生产表面活性剂、医药、农药、涂料、胶粘剂、离子交换树脂、增塑剂、甘油衍生物、缩水甘油衍生物以及氯醇橡胶的原料。以环氧氯丙烷与双酚A为主要原料制取的各类环氧树脂具有粘合性高、收缩性小、耐化学腐蚀、稳定性好等特点，广泛用作涂料、粘合剂、增强材料和浇铸材料等。以环氧氯丙烷为原料生产的氯醇橡胶是橡胶的新品种，在一般油和普通溶剂中不易膨胀，在低温无增塑剂存在下具有较大的挠性，具有优于丁腈、氯丁和丁基橡胶的某些特有的功能。
{Chem
急性毒性:口服- 大鼠 LD50: 90 毫克/ 公斤; 口服- 小鼠 LD50: 195 毫克/ 公斤