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JAK

下级目录

Cerdulatinib

Oclacitinib

LY 2784544

BMS-911543

Birabresib

WP-1034

5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile

INCB16562

Azd-1480

PACRITINIB

SB1578

XL019

TYRPHOSTIN AG 490

目录项下的产品

1198300-79-6

1198300-79-6 / MFCD298300796
4-(Cyclopropylamino)-2-((4-(4-(Ethylsulfonyl)Piperazin-1-Yl)Phenyl)Amino)Pyrimidine-5-Carboxamide
4-(环丙基氨基)-2-((4-(4-(乙基磺酰基)哌嗪-1-基)苯基)氨基)嘧啶-5-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1208319-26-9

1208319-26-9 / MFCD308319269
N-Methyl-1-(Trans-4-(Methyl(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Amino)Cyclohexyl)Methanesulfonamide
N-甲基-1-(反式-4-(甲基(7H-吡咯并[2,3-d]嘧啶-4-基)氨基)环己基)甲磺酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

1229236-86-5

1229236-86-5 / MFCD329236865
N-(3-(4-chloro-2-fluorobenzyl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-yl)-5-methyl-1,2-dihydro-3H-pyrazol-3-imine
3-(4-氯-2-氟苄基)-2-甲基-N-(5-甲基-1H-吡唑-3-基)-8-(吗啉甲基)咪唑[1,2-b]哒嗪-6-胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1271022-90-2

1271022-90-2 / MFCD371022902
N,N-Dicyclopropyl-4-((1,5-Dimethyl-1H-Pyrazol-3-Yl)Amino)-6-Ethyl-1-Methyl-1,6-Dihydroimidazo[4,5-D]Pyrrolo[2,3-B]Pyridine-7-Carboxamide
N,N-二环丙基-4-((1,5-二甲基-1H-吡唑-3-基)氨基)-6-乙基-1,6-二氢-1-甲基-咪唑并[4,5-d]吡咯并[2,3-b]吡啶-7-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

202590-98-5

202590-98-5 / MFCD02590985
OTX-015
OTX-015

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

857064-42-7

857064-42-7 / MFCD57064427
WP-1034

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

905586-69-8

905586-69-8 / MFCD005586698
AZ960 is a novel inhibitor of Jak2 kinase. AZ960 inhibits JAK2 kinase with a K(i) of 0.00045 microm in vitro and treatment of TEL-JAK2 driven Ba/F3 cells with AZ960 blocked STAT5 phosphorylation and potently inhibited cell proliferation (GI(50)=0.025 microm). AZ960 demonstrated selectivity for TEL-JAK2-driven STAT5 phosphorylation and cell proliferation when compared with cell lines driven by similar fusions of the other JAK kinase family members.
AZ960游离态

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

933768-63-9

933768-63-9 / MFCD033768639
INCB16562 is a novel, selective, and orally bioavailable small-molecule inhibitor of JAK1 and JAK2 markedly selective over JAK3. Treatment of myeloma cells with INCB16562 potently inhibited interleukin-6 (IL-6)-induced phosphorylation of STAT3. INCB16562 abrogated the protective effects of recombinant cytokines or bone marrow stromal cells and sensitized myeloma cells to cell death by exposure to dexamethasone, melphalan, or bortezomib. Oral administration of INCB16562 antagonized the growth of myeloma xenografts in mice and enhanced the antitumor activity of relevant agents in combination studies. INCB16562 is a potent JAK1/2 inhibitor and that mitigation of JAK/STAT signaling by targeting JAK1 and JAK2 will be beneficial in the treatment of myeloma patients, particularly in combination with other agents. ( source: Neoplasia. 2010 Jan;12(1):28-38. ).

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

935666-88-9

935666-88-9 / MFCD035666889
(S)-5-Chloro-N2-(1-(5-Fluoropyrimidin-2-Yl)Ethyl)-N4-(5-Methyl-1H-Pyrazol-3-Yl)Pyrimidine-2,4-Diamine
(S)-5-氯-N2-(1-(5-氟嘧啶-2-基)乙基)-N4-(5-甲基-1H-吡唑-3-基)嘧啶-2,4-二胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

937272-79-2

937272-79-2 / MFCD037272792
PACRITINIB
Pacritinib游离态

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

937273-04-6

937273-04-6 / MFCD037273046
SB1578

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

945755-56-6

945755-56-6 / MFCD045755566
(S)-N-(4-(2-((4-Morpholinophenyl)Amino)Pyrimidin-4-Yl)Phenyl)Pyrrolidine-2-Carboxamide
(S)-N-(4-(2-((4-吗啉代苯基)氨基)嘧啶-4-基)苯基)吡咯烷-2-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

133550-30-8

133550-30-8 / MFCD00209833
(E)-N-Benzyl-2-Cyano-3-(3,4-Dihydroxyphenyl)Acrylamide
(E)-N-苄基-2-氰基-3-(3,4-二羟苯基)丙烯酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

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