(S)-N-(4-(2-((4-Morpholinophenyl)Amino)Pyrimidin-4-Yl)Phenyl)Pyrrolidine-2-Carboxamide (S)-N-(4-(2-((4-吗啉代苯基)氨基)嘧啶-4-基)苯基)吡咯烷-2-甲酰胺
CAS 945755-56-6 MFCD045755566
化学结构图
SMILES: O=C(Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)[C@@H]1CCCN1
化学属性
| Mol. Weight | 444.53 |
|---|---|
| Appearance | Light yellow to light brown solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | (S)-N-(4-(2-((4-吗啉代苯基)氨基)嘧啶-4-基)苯基)吡咯烷-2-甲酰胺 |
|---|---|
| Chemical Name | (S)-N-(4-(2-((4-Morpholinophenyl)Amino)Pyrimidin-4-Yl)Phenyl)Pyrrolidine-2-Carboxamide |
| Formula | C25H28N6O2 |
| Synonym | XL019; XL-019; XL 019 |
| IUPAC Name | (S)-N-(4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)phenyl)pyrrolidine-2-carboxamide |
| InChIKey | ISOCDPQFIXDIMS-QHCPKHFHSA-N |
| InChI | InChI=1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11,13,23,26H,1-2,12,14-17H2,(H,28,32)(H,27,29,30)/t23-/m0/s1 |
| Canonical SMILES | O=C([C@H]1NCCC1)NC2=CC=C(C3=NC(NC4=CC=C(N5CCOCC5)C=C4)=NC=C3)C=C2 |
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产品应用
- XL019 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. XL019 inhibits the activation of JAK2 as well as the mutated form JAK2V617F, which may result in the inhibition of the JAK-STAT signaling pathway and may induce apoptosis. The JAK2 mutated form JAK2V617F has a valine-to-phenylalanine modification at position 617 and plays a key role in tumor cell proliferation and survival.
