Kinesin
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910634-41-2 / MFCD010634412
Litronesib, also known as LY2523355, is a n inhibitor of the kinesin-related motor protein Eg5 with potential antineoplastic activity. Litronesib selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and consequently cell death in tumor cells that are actively dividing. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein that plays an essential role during mitosis, particularly in the regulation of spindle dynamics, including assembly and maintenance. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
(-)-N-[4-(2,2-二甲基丙酰基)-5-[[2-(乙基氨基)乙磺酰胺]甲基]-5-苯基-4,5-二氢-1,3,4-噻二唑-2-基]-2,2-二甲基丙酰胺
