Monastrol (4S)-1,2,3,4-四氢-4-(3-羟基苯基)-6-甲基-2-硫代-5-嘧啶羧酸乙酯

CAS 254753-54-3 MFCD00813077

化学结构图

254753-54-3
SMILES: CC1NC(=S)NC(C=1C(=O)OCC)C1=CC(O)=CC=C1

化学属性

Mol. FormulaC14H16N2O3S
Mol. Weight292.35
Melting Point185-185.9 °C(lit.)
SolubilitySoluble in DMSO, not in water
Appearance Solid powder

别名和识别编码

Chemical NameMonastrol
CAS Number254753-54-3
Synonym 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester 6-Methyl-4-(3-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate MONASTROL Monastrol
MDL NumberMFCD00813077
PubChem Substance ID24897267
Chemical Name Translation(4S)-1,2,3,4-四氢-4-(3-羟基苯基)-6-甲基-2-硫代-5-嘧啶羧酸乙酯
FormulaC14H16N2O3S
IUPAC Nameethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
InChIKeyLOBCDGHHHHGHFA-UHFFFAOYSA-N
InChIInChI=1S/C14H16N2O3S/c1-3-19-13(18)11-8(2)15-14(20)16-12(11)9-5-4-6-10(17)7-9/h4-7,12,17H,3H2,1-2H3,(H2,15,16,20)
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分类

  • {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Cycle Proteins and Antibodies, Cell Cycle Regulators, Cell Signaling and Neuroscience, M
  • Inhibitors,
  • {SNA} Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, M, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

产品应用

  • Monastrol is a kinesin Eg5 inhibitor. Induction of apoptosis by monastrol is independent of the spindle checkpoint. Monastrol binds to the KSP-ADP complex, forming a KSP-ADP- monastrol ternary complex, which cannot bind to microtubules productively and cannot undergo further ATP-driven conformational changes.

相关文献及参考

  • Mayer, T.U., et al.: Science, 286, 971 (1999),

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Storage condition 2-8°C Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

其他信息

  • MOL 文件:254753-54-3.mol
  • Sigma Aldrich:254753-54-3(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Cell Cycle Proteins and Antibodies - Apoptosis and Cell Cycle
  6. Cell Cycle Regulators - Cell Cycle Proteins and Antibodies
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Cell Cycle Proteins and Antibodies - Apoptosis and Cell Cycle
  6. Cell Cycle Regulators - Cell Cycle Proteins and Antibodies
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Kinesin

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