CAS 135-20-6 MFCD00078422-Cupferron 铜铁试剂 TAO{mole}

Cupferron 铜铁试剂

CAS 135-20-6 MFCD00078422

化学结构图

SMILES: O=NN([O-])c1ccccc1.[NH4+]

化学属性

Mol. Formula	C6H5N(NO)ONH4
Mol. Weight	155
Melting Point	150-155
TSCA	Yes
Solubility	<0.1 G/100 ML AT 18.5 ºC
Density	1.127
Appearance	白色或奶色鳞片状结晶。熔点163-164℃，易溶于水及醇。
Stability	对光和热敏感

别名和识别编码

Chemical Name	Cupferron
MDL Number	MFCD00078422
CAS Number	135-20-6
Reaxys-RN	13430213
Merck Number	2622
Beilstein Registry Number	3919107
PubChem Substance ID	87565736
Synonym	AMMONIUM NITROSOPHENYLHYDROXYLAMINE AMMONIUM SALT OF NITROSOPHENYLHYDROXYLAMINE Ammonium N-nitrosophenylhydroxylamine COPPERONE CUPFERRON Cupferon N-NITROSO-N-PHENYLHYDROXYAMINE AMMONIUM SALT N-NITROSO-N-PHENYLHYDROXYLAMINE N-NITROSO-N-PHENYLHYDROXYLAMINE NH3 N-NITROSO-N-PHENYLHYDROXYLAMINE, AMMONIUM DERIVATIVE N-Nitroso-N-phenylhydroxylamine Ammonium Salt, Ammonium Nitrosophenylhydroxylamine N-Nitrosofenylhydroxylamin amonny N-PHENYL-N-NITROSOHYDROXYLAMINE AMMONIUM SALT N-亚硝基-N-苯基羟胺铵盐 N-亚硝基苯胲 N-亚硝基苯胲铵 N-亚硝基苯胲铵盐 N-亞硝苯胲 N-羟基-N-亚硝基苯胺铵盐 NCI-C03258 am 亚硝基苯胲铵盐庫番龍銅鐵靈铜铁灵铜铁试剂铜铁试剂 (停产)
EC Number	205-183-2
Chemical Name Translation	铜铁试剂
Wiswesser Line Notation	QNR&NO &ZH
LabNetwork Molecule ID	LN01740998
InChI	InChI=1S/C6H6N2O2.H3N/c9-7-8(10)6-4-2-1-3-5-6;/h1-5,9H;1H3/b8-7-;

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产品应用

比色测定铝、铋、铜、铁汞、锌、锰、铌、镓、钽、钍、钛、钒、锡等元素的重量测定。在强酸溶液中定量测定铁，定量分析钒酸盐，与其他金属在一起时分离铜和铁，测稀土时作掩蔽剂。

安全信息

RTECSNC4725000

UN Number 2811 UN 2811 6.1/PG 3

Signal word Danger

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P310
P301+P310+P330
P302+P350
P302+P352+P332+P313+P362+P364
P305+P351+P338
P305+P351+P338+P337+P313
P308+P313
P332+P313
P337+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Storage condition 0-10 0-10°C 2-8°C 储存温度2-8℃

Hazard statements

H301 Toxic if swallowed 吞食有毒
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激
H351 Suspected of causing cancer 怀疑致癌

GHS Symbol

WGK Germany3

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Safety Statements

S20 When using do not eat or drink 使用时，不得进食，饮水；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；

Packing GroupIII

Risk Statements

R25 Toxic if swallowed 吞咽有毒
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

Hazard Codes 6.1 T

Hazard Class6.1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 123 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Vascular - tumors
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-100,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 437 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Vascular - tumors
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-100,1978

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9040 mg/kg/65W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   ZEKBAI Zeitschrift fuer Krebsforschung.  (Berlin, Fed. Rep. Ger.)  V.1-75,
   1903-71.  For publisher information, see JCROD7.  Volume(issue)/page/year:
   69,103,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 199 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 32(3),48,1988

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KODAK* Kodak Company Reports.  (343 State St., Rochester, NY 14650)
   Volume(issue)/page/year: 21MAY1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#04968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KODAK* Kodak Company Reports.  (343 State St., Rochester, NY 14650)
   Volume(issue)/page/year: 21MAY1971

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 333 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7(Suppl
   5),1,1985

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - grasshopper
DOSE/DURATION           : 1 pph
REFERENCE :
   JCGEDO Journal of Cytology and Genetics.  (Soc. of Cytologists and
   Geneticists, Treasurer, Karnatak Univ., Dept. of Botany, Dharwad, 580003,
   India)  V.1-    1966-  Volume(issue)/page/year: 1,75,1966

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 13,2389,1992

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7(Suppl
   5),1,1985

其他信息

Sigma Aldrich:135-20-6(sigmaaldrich)
Alfa Aesar:N-亚硝基苯胲,ACS Cupferron(135-20-6)
TCI Shanghai:铜铁试剂 Cupferron(135-20-6)
MOL 文件:135-20-6.mol
Acros Organics:铜铁试剂 Cupferron, 99%(135-20-6)
上游原料:碳酸铵 --> 亚硝酸丁酯 --> 苯基羟胺
提纯方法:在120ml60℃水中加入30g粉末状的粗品，使之全部溶解，加入2g粉末状活性炭，搅拌10～15min，用灼烧过的布氏漏斗过滤，将滤液冷却至10～15℃，再冷至0℃放置过夜。用玻璃砂漏斗抽滤析出的结晶，用10ml乙醇洗涤，再用10ml乙醚洗涤，在空气中干燥。铜铁试剂也可以用乙醇重结晶加以精制。
用途二:比色测定铝、铋、铜、铁汞、锌、锰、铌、镓、钽、钍、钛、钒、锡等元素的重量测定。在强酸溶液中定量测定铁，定量分析钒酸盐，与其他金属在一起时分离铜和铁，测稀土时作掩蔽剂。
易溶于水及醇，久置颜色变深，一般在瓶内放置少量用纸(或布)包好的碳酸铵作稳定剂。
急性毒性:口服-大鼠LD 50: 199 毫克/公斤; 静脉-小鼠LD50:180 毫克/公斤
铜铁试剂价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 10008314 铜铁试剂;N-亚硝基苯基羟胺铵盐; N-亚硝基苯胲胺盐; 铜铁灵 25g 20.1元 2011/08/23 10008380 铜铁试剂;N-亚硝基苯基羟胺铵盐; N-亚硝基苯胲胺盐; 铜铁灵 25g 1015元 2011/04/16 C0646 铜铁试剂 Cupferron 500G 2640元
储运特性:库房通风低温干燥
类别:农药
方法一:将苯胲乙醚溶液在冰溶中冷却，通入氨至过量，在搅拌和继续通氨的情况下，滴加亚硝酸正丁酯，1h左右加完，再搅拌15min。滤出铜铁灵沉淀，用乙醚洗涤，干燥得成品。该品应贮放在棕色玻瓶中，瓶内放置少量用纸（或布）包好的碳酸铵作稳定剂。
分析试剂:铜铁试剂是一种重要的分析试剂，为N-亚硝基羟胺的铵盐，俗称铜铁灵。通常情况下为白色或淡黄色光亮的鳞片状结晶，有甜味，久置因慢慢分解而颜色变暗，但实际上还可以在分析上使用。它易溶于水、苯、醇、醚。试剂受热分解生成硝基苯。在光和空气中不稳定，需要保存在棕色磨口试剂瓶中，通常瓶内放置少量用纸或布包好的碳酸铵作为防腐剂，放在密封避光阴凉处。可用作铜、铁、锡、钛、钒、铬等元素的沉淀剂和溶剂萃取剂，测定稀土作掩蔽剂。将硝基苯用锌粉在氯化铵水溶液中还原，得到苯基羟胺，再将后者溶于乙醚中，通入过量氨气，并加入亚硝酸正丁酯，则得铜铁试剂，能与多种金属离子形成稳定的五元环螯合物，因此，它是常用的有机沉淀剂。可在强酸溶液中定量测定Fe3+离子，还可测定Cu2+，Sn4+，Ti4+，Ga3+，Hf4+等离子以及钒酸盐(VO-3，VO3-3)。当Fe3+，Cu2+离子与其它金属离子混在一起时，可用此试剂将它们分离出来。又是Al3+，Au3+，Be2+，Co2+，La3+，Pu4+等离子的螯合萃取剂及测定稀土金属离子的掩蔽剂等。
可燃性危险特性:高温产生有毒氮氧化物和氨烟雾
爆炸物危险特性:与钍盐, 锆盐或钛盐的溶液室温起爆
毒性分级:高毒
用途一:化学分析试剂，测定铝、铜、铁、钛、锆及其他金属。
图谱信息:铜铁试剂(135-20-6)红外图谱(IR2) 铜铁试剂(135-20-6)红外图谱(IR1) 铜铁试剂(135-20-6)核磁图( 1 HNMR) 铜铁试剂(135-20-6)核磁图( 13 CNMR)
灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
刺激数据:眼睛-兔子 20 毫克/24小时中度