N,N'-Methylenebisacrylamide N,N'-亚甲基双丙烯酰胺

CAS 110-26-9 MFCD00008625

化学结构图

110-26-9
SMILES: C=CC(=O)NCNC(=O)C=C

化学属性

Mol. FormulaC7H10N2O2
Mol. Weight154.17
Melting Point>300 °C
Density1.235
TSCAYes
Vapor Density5.31 (vs air)
Solubility0.01-0.1 G/100 ML AT 18 ºC
Stability对光和空气敏感
Appearance powder 是一种白色晶体粉末,无味,吸湿性极小。遇高温或强光则自交联,微溶于水、乙醇。密度 1.235 ,熔点 185°C ,水溶性 0.01-0.1 g/100 mL at 18°C
Boiling Point277.52 °C at 760 mmHg

别名和识别编码

Chemical NameN,N'-Methylenebisacrylamide
Synonym N,N'-Methylenebisacrylamide {LY} N,N'-Methylenebisacrylamide {} {LY} N,N'-Methylenebisacrylamide {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Methylenebisacrylamide {} {} {} {} {} {} {}
CAS Number110-26-9
PubChem Substance ID354333741
EC Number203-750-9
Beilstein Registry Number1706297
MDL NumberMFCD00008625
Reaxys-RN1706297
Chemical Name TranslationN,N'-亚甲基双丙烯酰胺
Wiswesser Line Notation1U1VM1MV1U1
LabNetwork Molecule IDLN00194689
InChIInChI=1S/C7H10N2O2/c1-3-6(10)8-5-9-7(11)4-2/h3-4H,1-2,5H2,(H,8,10)(H,9,11)
Canonical SMILESC=CC(NCNC(C=C)=O)=O
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分类

  • {SNA} Gel Cross-Linkers, SDS-PAGE, 分子生物学, 蛋白电泳, 蛋白质组学
  • {SNA} Protein Sequencing,
  • {
  • {SNA} Acrylamide, Acrylamides,
  • {SNA} Acrylamides, Core Bioreagents, Electrophoresis of Glycans, Gel Cross-Linkers, Glycan Labeling and Analysis, Glycobiology, Life Science Reagents for DNA/RNA E

产品应用

  • 用于和丙烯酰胺混合制备聚丙烯酰胺凝胶,用在蛋白质和核酸电泳中。N,N′-Methylenebis(acrylamide)

相关文献及参考

  • Crosslinking agent for the synthesis of polyacrylamide gels.
  • Crosslinking agent for the synthesis of polyacrylamide gels.
  • 2. D. Rickwood, B.D. Hames Gel Electrophoresis of Nucleic Acids: A Practical Approach Oxford , (1983)

安全信息

GHS Symbol
WGK Germany2
Hazard Codes Xn
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H332 Harmful if inhaled 吸入有害
Personal Protective Equipment Eyeshields, Faceshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) dust mask type N95 (US), Eyeshields, Faceshields, Gloves Eyeshields, Faceshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Faceshields, Gloves
RTECSAS3678000
Signal word Warning
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
UN Number 2811 UN 2811
Packing GroupIII
Storage condition 2-8°C, stored under nitrogen {LY} 2-8°C, stored under nitrogen {} {LY} 2-8°C, stored under nitrogen {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitro
Hazard Class6.1(b)
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 380 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 390 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - tremor
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,111,1990

TYPE OF TEST            : LC - Lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >41 ppm/6H
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,111,1990

TYPE OF TEST            : LC - Lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >41 ppm/6H
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,1

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 600 ppm
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   23,208,1994

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11(Suppl 12),1,1988

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 225 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 229,161,1990

TYPE OF TEST            : Heritable translocation test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 450 mg/kg/5D (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 229,161,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 225 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 229,161,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3208 mg/kg
SEX/DURATION            : male 16 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   47,179,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 360 mg/kg
SEX/DURATION            : female 6-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB92-177781

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE

其他信息

  • 用途三:用作分离氨基酸的重要材料及光敏尼龙或光敏塑料的重要原料
  • Acros Organics:N,N'-亚甲基双丙烯酰胺 N,N'-Methylenebisacrylamide, extra pure, 96%(110-26-9)
  • 图谱信息:N,N'-亚甲基双丙烯酰胺(110-26-9)红外图谱(IR2) N,N'-亚甲基双丙烯酰胺(110-26-9)红外图谱(IR1) N,N'-亚甲基双丙烯酰胺(110-26-9)Raman光谱 N,N'-亚甲基双丙烯酰胺(110-26-9)质谱(MS)
  • 蒸气密度:5.31 (vs air)
  • TCI Shanghai:N,N'-亚甲基双丙烯酰胺[用于电泳] N,N'-Methylenebisacrylamide [for Electrophoresis],>;98.0%(T)(110-26-9)
  • 上游原料:丙烯酰胺
  • 用途四:生物高分子化合物(蛋白质、多肽、核酸)的分离。制备聚丙烯酰胺凝胶的交联剂。聚丙烯酰胺凝胶技术和临床检验。
  • Alfa Aesar:N,N'-甲烯基双丙烯酰胺,99+% N,N'-Methylenebisacrylamide, 99+%(110-26-9)
  • 海关编码:29241900
  • MOL 文件:110-26-9.mol
  • Sigma Aldrich:110-26-9(sigmaaldrich)
  • N,N'-亚甲基双丙烯酰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30117826 N,N-亚甲基双(丙烯酰胺) 100g 92元 2011/08/23 k6667001 N.N-亚甲基双(丙烯酰胺) 100g 430元 2011/08/23 S14607203 N,N’-亚甲基双丙烯酰胺 100g 472元
  • MSDS 信息:N,N'-Methylenebis(2-propenamide)(110-26-9).msds
  • F:8
  • 用途一:用作光敏尼龙和光敏塑料原料、建筑灌浆材料,也用于照相、印刷、制版等
  • 用途二:可在油田钻井作业中和建筑灌浆作业中用作堵水剂,亦可在丙烯酸树脂和粘合剂合成中用作交联剂
  • 下游产品:微波法合成的阳离子高吸水性树脂 --> 微波法合成的两性高吸水性树脂
  • 无气味,吸湿性极小。对光敏感。遇高温或强光则自交联,微溶于水,溶于乙醇。水中溶解度:3 g/L (25°C),水溶液可因水解而形成丙烯酸和氨。中等毒,半数致死量(大鼠,经口)390mg/kg。有刺激性。

系列性分类


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